Bilateral Pheochromocytoma and Medullary Thyroid Cancer

Abstract


Introduction: Pheochromocytoma is one of representative of neuroendocrine tumors. According this fact, pheochromocytoma remains to evaluation for multiply endocrine neoplasia, especially if disease is bilateral. In this case, it is necessary to additionally carry out a genetic screening test.

The aim of the study is to Improve diagnosis and treatment outcomes for patients with MEN syndrome.

Materials and methods: The authors present a clinical case of a 37-year-old man diagnosed and treated for a bilateral pheochromocytoma.

Results: The patient was diagnosed medullary thyroid cancer after successful bilateral adrenalectomy. The patient underwent thyroidectomy. A genetic research showed the T1900 mutation in the codon of 634 RET gene, which confirmed the presence of the patient MEN 2 syndrome. According to the high concordance of the mutated gene, patient's son was carried out to genetic examinations, which confirmed the presence of this mutation. The boy underwent thyroidectomy opportunely.

Discussion: Due to primary oncological observation if the patient has pheochromacytoma, it is necessary to exclude MAN 2 syndrome both in the patient himself and his relatives. The safest and informative method is genetic research.

Conclusion: presently a comprehensive examination of both the patient himself and his relatives is necessary for timely diagnosis and correct management of treatment patients with MEN 2 syndrome.


Vyacheslav Petrovich Zemlyanoy

I.I. Mechnikov Northwest State Medical University

Email: vyacheslav.zemlyanoy@szgmu.ru

Russian Federation, 41 Kirochnaya Str., St. Petersburg, 191015, Russian Federation

MD, Prof., the head of the Department of faculty surgery named after I.I. Grecov, dean of the Surgical Faculty

Aleksandr Aleksandrovich Lisitsyn

I.I. Mechnikov Northwest State Medical University

Author for correspondence.
Email: aleksandr.lisitsyn@szgmu.ru
ORCID iD: 0000-0003-2045-0044

Russian Federation, 41 Kirochnaya Str., St. Petersburg, 191015, Russian Federation

PhD, assistant professor of the Department of faculty surgery

Mikhail Mikhailovich Nakhumov

I.I. Mechnikov Northwest State Medical University

Email: mikhail.nakhumov@szgmu.ru

Russian Federation, 41 Kirochnaya Str., St. Petersburg, 191015, Russian Federation

PhD, assistant professor of the Department of faculty surgery

Evgeniya Mikhailovna Nesvit

I.I. Mechnikov Northwest State Medical University

Email: aleksandr.lisitsyn@szgmu.ru

Russian Federation, 41 Kirochnaya Str., St. Petersburg, 191015, Russian Federation

resident of the Department of faculty surgery

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