Metal Nanoparticle Effect on Regeneration of Experimental Wounds


The purpose of the study Effect of the suspensions of copper and zinc nanoparticles on regeneration of an experimental conditionally aseptic wound when applied locally. Materials and methods The research object was60 laboratory white rats; copper, zinc nanoparticles generated with the help of plasma technology as suspensions in isotonic sodium chloride solution. Modeling of a full-layer conditionally aseptic wound was carried out in the interscapular region with an area of 400 mm². In the work experimental, planimetric, microbiological and statistical research methods were used. Results and their discussion The change of the area of the conditionally aseptic wound in experimental animals, conditionally aseptic wound healing rate (in mm²/day), diurnal reduction of the area of experimental wounds (in %) in dynamics are analysed. In animals of the experimental group taken the treatment by the suspension of copper nanoparticles a fast healing of the wound surface was observed. During the whole period of the research the healing of the wound surface of the animals of the experimental group was more active than in case of the comparison group because of the absence of the reinfection, that is connected to the evident antibacterial action of copper nanoparticles. Under the influence of the suspension of zinc nanoparticles stimulation of wound regeneration, earlier complete healing was observed as well, but some animals had wound infection resulted in expansion of the wound surface. It confirms the evident regenerative action of zinc nanoparticles in case of an absence or low-grade antiseptic effect. Conclusion The analysis of healing rate of conditionally aseptic wounds, diurnal reduction of the area of experimental wounds in dynamics confirms the effect of copper and zinc nanoparticles as a suspension on soft tissue wound regeneration.

Saratov Research Institute of Traumatology and Orthopaedics, Saratov, Russian Federation

Author for correspondence.
Ph.D., Senior Research Assistant of the Department of Fundamental and Clinical Experimental Research of Federal Government-Financed Institution “Saratov Research Institute of Traumatology and Orthopaedics” of Ministry of Public Health of the Russian Federation

  1. Abaev Iu.K. Spravochnik khirurga. Rany i ranevaia
  2. infektsiia [Directory of the surgeon. Wounds and wound
  3. infection]. Rostov-na-Donu, Feniks, 2006. 427. – (In
  4. Russian).
  5. Glushchenko N.N., Bogoslovskaia O.A., Ol'khovskaia I.P. Fiziko-himicheskie zakonomernosti biologicheskih ehffektov vysoko
  6. dispersnye poroshki metallov
  7. [Physical and chemical laws of biological effects highly
  8. dispersed powders of metals]. Khimicheskaia fizika, 2002;
  9. (4): 79-85. – (In Russian).
  10. Glushchenko N.N., Varlamov V.P., Baitukalov O.A. Med'
  11. nanochasticy i nanochasticy hitozana v ranozazhivlyayushchim agentov [Copper
  12. nanoparticles and nanoparticles of chitosan in the wound-healing agents]. Mikroelementy v meditsine, 2008; 9: 12: 51.
  13. – (In Russian).
  14. Glushchenko N.N., Skal'nyi A.V. Toksichnost' cinka
  15. nanochasticy i ego biologicheskie svojstva [The toxicity of zinc
  16. nanoparticles and its biological properties]. Aktual'nye
  17. voprosy transportnoi meditsiny, 2010; 3(21): 118-121. – (In
  18. Russian).
  19. Gostishchev V.K. Infektsii v khirurgii [Infection in surgery].
  20. Moscow, GEOTAR-Media, 2007. 768. – (In Russian).
  21. Kuzin M.I., Kostiuchenok B.M. Rany i ranevaia infektsiia
  22. [Wounds and wound infection] . Moscow, Meditsina, 1990.
  23. – (In Russian).
  24. Rakhmetova A.A., Bogoslovskaia O.A., Ol'khovskaia
  25. I.P., Alekseeva T.P., Leipunskii I.O., Glushchenko N.N. Ranozazhivlyayushchie svojstva novogo pokoleniya na
  26. v osnove nanochastic medi
  27. [Wound healing properties of the new generation on
  28. the basis of copper nanoparticles]. Sbornik trudov Kh
  29. Mezhdunarodnogo kongressa «Zdorov'e i obrazovanie v
  30. XXI veke: innovatsionnye tekhnologii v biologii i meditsine,
  31. » [Collection of works of X International Congress
  32. "Health and Education in the XXI Century: Innovative
  33. Technologies in Biology and Medicine, 2009"]. Moscow
  34. ; 299-300. – (In Russian).
  35. Rakhmetova A.A., Alekseeva T.P., Bogoslovskaia O.A. Ranozazhivlyayushchie svojstva nanochastic medi,
  36. v zavisimosti ot ih fiziko-himicheskih harakteristik
  37. [Wound healing properties of copper nanoparticles,
  38. depending on their physical and chemical characteristics of
  39. the]. Rossiiskie nanotekhnologii, 2009; 3-4: 102-108. – (In
  40. Russian).
  41. Datsenko B.M. Teoriia i praktika mestnogo lecheniia
  42. gnoinykh ran. (Problemy lekarstvennoi terapii) [Theory
  43. and practice of local treatment of purulent wounds.
  44. (Problems of drug therapy)]. Kiev, “Zdorov,ja”, 1995. 383
  45. p. – (In Russian).


Abstract - 67

PDF (Russian) - 168



Copyright (c) 2013 .

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies