The Mucous Membrane of Oral Cavity at Experimental Chronic Renal Insufficiency


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Abstract

The purpose of the study By morphological methods to investigate reactions of mucous membrane in rat oral cavity at the renal insufficiency. Matherials and methods The changes of a mucous membrane in rat oral cavity at the chronic renal insufficiency (CRI) of various degrees were studied by methods of light microscopy. Results and their discussion It was revealed that in 6 months after modeling of easy or mild CRI the mucous membrane in an oral cavity was diffuse infiltrated by leukocytes, the volume density of blood and lymphatic vessels was in-creased. Rats with high grade of CRI have an atrophy and hyperkeratoses of mouth epithelium, sclerosis of a mucous membrane was detect, the number of leukocytes considerably increased, first of all, neutrophils, monocytes, macrophages, small leukocytic infiltrates were formed. Besides, at mild or high grade of CRI in mucous membrane of an oral cavity the quantity of eosinophils and plasmatic cells increases that points to possible presence of a considerable allergic component in initiation and maintenance of inflammation in mouth tissues at CRI. Conclusion CRI, even easy degree, leads to considerable changes of a mucous membrane of the rat oral cavity, consisting in an atrophy of an epithelium, sclerous transformation of a mucous membrane, stomatitis and gingivitis, a being accompanied diffusion and focal leukocyte infiltration and vascular disturbances. Key words Chronic renal insufficiency, mucous membrane

About the authors

Scientific center of Reconstructive and recovery surgery Ministries of Health of Kyrgyzstan, Bishkek, Kyrgyzstan

Author for correspondence.
Email: author@vestnik-surgery.com
Junior Researcher at the Department of Morphology at the Research Center of Reconstructive Surgery, Ministry of Health of Kyrgyzstan, Bishkek, Kyrgyzstan

Kyrgyz state medical institute of retraining and increase qualifications, 144a Bokonbaeva Str., Bishkek, 720040, Kyrgyzstan

Email: author@vestnik-surgery.com
Candidate of Medical Science, Assistant Professor of the Department of Radiology of Kyrgyz State Medical Institute of Advanced Trainig, Bishkek, Kyrgyzstan

The Center of New Medical Technologies, Institute of Chemical Biology and Fundamental Medicine, The Russian Academy of
Sciences, 8 Akademika Lavrent'eva Ave., Novosibirsk, 630090, Russian Federation

Email: author@vestnik-surgery.com
Candidate of Medical Science, Doctoral Candidate of the Stem Cell Laboratory, Institute of Chemical Biology and Fundamental Medicine of SB RAS

The Center of New Medical Technologies, Institute of Chemical Biology and Fundamental Medicine, The Russian Academy of
Sciences, 8 Akademika Lavrent'eva Ave., Novosibirsk, 630090, Russian Federation

Email: imai@mail.ru
Doctor of Medical Science, Professor, Senior Researcher at the Stem Cell Laboratory, Institute of Chemical Biology and Fundamental Medicine of SB RAS, Novosibirsk, Russia

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