Journal of Experimental and Clinical SurgeryJournal of Experimental and Clinical Surgery2070-478X2409-143XVoronezh State Medical University12810.18499/2070-478X-2012-5-2-%pUnknownThe evaluation of the possibility of mediator treatment influence on the expression of messenger RNA in mononulear blood cells in patients with acute pancreatitisauthor@vestnik-surgery.comauthor@vestnik-surgery.comauthor@vestnik-surgery.comauthor@vestnik-surgery.com24062012522704201627042016Copyright © 2012, ., ., ., .2012<p>Recent studies have established the leading role of inflammatory mediators in the pathogenesis of acute pancreatitis. One of <br />the mechanisms for starting of the whole cascade of inflammation is the activation of the innate immune system component <br />- Toll - like receptors. In this study the possibility of effects on the level of expression of messenger RNA TLR2 and TLR4 <br />receptors in peripheral blood mononuclear cells of patients with acute pancreatitis by anti-mediator therapy was analyzed</p>acute pancreatitisToll - like receptorsanti-mediator therapyраспространенный гнойный перитонит«Омегавен»липид-транспортная системафосфолипидыхолестерол[1. Bianchi ME. DAMPS, PAMPs i alarmins: vse, chto nam nuzhno znat' ob opasnosti [DAMPs, PAMPs and alarmins: all we need to know about danger]. J Leukoc Biol. 2007, 81, 1–5.][2. Erridge C.Jendogennye ligandy TLR2 i TLR4: agonisty ili pomoshhniki? [Endogenous ligands of TLR2 and TLR4: agonists or assistants?] J. Leukoc Biol. 2010, 87(6), 989-99.][3. Harter L., Mica L., Stocker R., Trentz O., Keel M. Povyshennaja jekspressija Toll-podobnye receptory-2 i -4 na lejkocitah u pacientov s sepsisom [Increased expression of toll-like receptor-2 and -4 on leukocytes from patients with sepsis]. Shock, 2004,22(5), 403-409.][4. Hidehiro Sawa., Takashi Ueda. Yoshifumi Takeyama, Takeo Yasuda, Makoto Shinzeri et al. Rol' Toll-podobnyj receptor 4 v patofiziologii tjazhelom ostrom pankreatite u myshej [Role of Toll-like receptor 4 in the pathophysiology of severe acute pancreatitis in mice]. Surg.Today, 2007, 37, 867-873.][5. Li Y., Zou Z.G. Xia Q.J., Zang J., Li H.G. et al.Toll-podobnyj receptor 4 obnaruzhen v jekzokrinnoj chasti podzheludochnoj zhelezy i izmenenie jekspressii v nebesno-inducirovannogo pankreatita [Toll-like receptor 4 detected in exocrine pancrease and the change of expression in cerulean-induced pancreatitis]. Pancreas. 2005, 30, 375-381.][6. Li Yu, Liantang Wang, Shangwu Chen Jendogennye Toll-podobnye ligandy receptorov i ih biologicheskoe znachenie [Endogenous toll-like receptor ligands and their biological significance]. J.Cell. Mol.Med. 2010,14(11), 2592-2603.][7. Montero Vega M.T., de Andrés Martín A.Znachenie Toll-podobnyh receptorov v chelovecheskih zabolevanijah [The significance of toll-like receptors in human diseases]. Allergol Immunopathol., 2009, 37(5), 252-263.][8. Petrov M.S., Windsor J.A.Klassifikacija tjazhesti ostrogo pankreatita: Skol'ko kategorii oshhushhajutsja? [Classification of the Severity of Acute Pancreatitis: How Many Categories Make Sense?] Am. J. Gastroenterol 2010; 105:74–76.][9. Sabroe I.,Parker L.C.,Dower S.K.,Whyte M.K. Rol' aktivacii TLR v vospalitel'nyh processah [The role of TLR activation in inflammation]. J Pathol.,2008 214(2),126-135]