Journal of Experimental and Clinical SurgeryJournal of Experimental and Clinical Surgery2070-478X2409-143XVoronezh State Medical University13710.18499/2070-478X-2012-5-2-315-319UnknownChange of some coagulation-lytic system of blood in the ischemic area of the small intestine after intravenous, subcutaneous and intraoperative paravasal routes of administration of heparin in the experimentauthor@vestnik-surgery.comauthor@vestnik-surgery.comauthor@vestnik-surgery.comauthor@vestnik-surgery.com24062012523153192704201627042016Copyright © 2012, ., ., ., .2012<p>The aim of the study was a comparative evaluation of the effectiveness of distinct prevention of abdominal adhesions after <br />intravenous, subcutaneous and intraoperative paravasal routes of administration of heparin in conditions of ischemic injury <br />of the small intestine. The paper presents an experimental study conducted on 40 adult mongrel dogs were divided into 4 <br />groups (10 dogs in each group). The first group formed the stomach in kind, which was not carried out heparin, the second <br />- the animals, which the eye was performed, intravenous heparin, and the third - the animals, which produced subcutaneous <br />heparin and the fourth - of animals, which was carried out intraoperative heparin in the tissue of a neurovascular beam <br />mesentery. From the venous vessel, directly adjacent to the ischemic area of the small intestine 20 minutes after creating <br />the model for the fracture circulatory organs are made to draw blood with subsequent study of several coagulation-analytic <br />system of blood: clotting time by Lee-White, prothrombin time and prothrombin ratio, the activity of antithrombin III. <br />After taking the blood from the venous vessel last tied. Then, the surgical wound sutured in layers. Postoperatively, any <br />treatment of animals was conducted. At various times after surgery were evaluated functional and morphological changes in <br />the experimental section of the intestine. Based on the data shown conclusive advantages of intraoperative paravasal the set <br />route of administration of heparin in the prevention of abdominal adhesions.</p>coagulation-lytic systemheparinкоагуляционно-литическая системагепарин[1. Gondzhilashvili V.G., Kozlov V.I., Kaz'min I.A. Sosto-ianie mikrotsirkuliatornogo rusla v oblasti lazernogo][«svarnogo» tonkokishechnogo anastomoza [Status of the microvasculature in the field of laser]["Weld" enteric anastomosis]. Khirurgiia.][1992; 9-10: 39-46.][2. Kobshov E.E. K mekhanizmu spaikoobrazovaniia u detei.][Sovremennye tekhnologii v pediatrii i detskoi khi-rurgii [The mechanism of adhesion in children.][Modern technologies in pediatrics and pediatric surgery]. Moskva2005; 339-339.][3. Konovalov A.K., Sergeev A.V. Snizhenie travmatichno-sti endokhirurgicheskogo lecheniia spaechnoi bolezni u][detei. Sovremennye tekhnologii v pediatrii i detskoi][khirurgii [Reduced trauma endosurgical treatment of adhesive disease in][children. Modern technologies in pediatrics and child][surgery]. Moskva. 2004; 464-465.][4. Kriger A.G., Andreitsev I.L., Gorskii V.A. i soavt. Dia-gnostika i lechenie ostroi spaechnoi tonkokishechnoi][neprokhodimosti [Diagnosis and treatment of acute adhesive intestinal][obstruction]. Khirurgiia. 2001; 7: 25- 29.][5. Markos'ian S.A. Vozrastnye osobennosti regeneratsii][tkanei kishechnoi trubki pri ishemicheskom povrezhde-nii [Age features of regeneration][intestinal tissue damage in ischemic tube]. Saransk. 2001; 79.][6. Starkov Iu.G., Domarev L.V., Shishin K.V., Solodinina][E.N. Ul'trazvu kovoe kartirovanie vistseroparietal'-nykh srashchenii briushiny pered laparoskopicheskimi][operatsiiami [Ultrasound mapping vistseroparietal-governmental fusion of laparoscopic peritoneal before][operations]. Med. vizualizatsiia. 2002; 4: 22-26.][7. Fedorov V.D., Kubyshkin V.A., Kozlov I.A. Khirurgiche-skaia«epidemiologiia» obrazovaniia spaek v briushnoi][polosti [Surgical "epidemiology" the formation of adhesions in the abdominal][cavity]. Khirurgiia. 2004; 6: 50-53.][8. Parker M.C., Ellis H., Moran B.J. Dis priamaia kishka][[colon rectum]. Dig.][Surg. 2001; 44: 6: 822- 829]