Journal of Experimental and Clinical SurgeryJournal of Experimental and Clinical Surgery2070-478X2409-143XVoronezh State Medical University148610.18499/2070-478X-2021-14-3-243-247UnknownHistory of Development and Potentials of Plasma SurgerySokolovaAnna Sergeevna<p>Candidate of Medical Sciences, Assistant of the Department of Faculty Surgery named after I. I. Grekov</p>a.s.sokolova84@gmail.comhttps://orcid.org/0000-0002-0020-2257SiguABadri Valerievich<p>MD, PhD, professor of the Department of Faculty Surgery named after I.I. Grekova</p>dr.sigua@gmail.comhttps://orcid.org/0000-0002-4556-4913ZemlyanoyVyacheslav Petrovich<p>MD, PhD, professor, Head of the Department of Faculty Surgery named after I.I. Grekova</p>zeml.spb@mail.ruhttps://orcid.org/0000-0003-2329-0023North-Western state medical University named after I. I. Mechnikov, Saint Petersburg,RussiaNorth-West State Medical University named after I.I. Mechnikov2008202114324324715022021Copyright © 2021, Sokolova A.S., SiguA B.V., Zemlyanoy V.P.2021<p>Two hundred years have passed since the moment when Michael Faraday suggested the existence of substances of the fourth aggregate state. A long way has been spent studying plasma and its properties, searching for possible applications in various directions. Many specialists in various fields of medicine have conducted research on the use of unique properties of plasma for sterilization of equipment, treatment of various diseases and prevention of their complications. However, the potential of plasma use continues to open up novel ways of its application.</p>plasmahistory of discoveryimpact mechanismsapplicationsплазмаистория открытиямеханизмы воздействияобласти применения[1. Geoffrey N. Cantor. Michael Faraday: Sandemanian and scientist. Springer. 2016; 180-182.][2. Khramov YuA. Crooks William. 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Sensenig R, Kalghatgi S, Cerchar E, Fridman G, Shereshevsky A. Retraction note to: Non-thermal plasma induces apoptosis in melanoma cells via production of intracellular reactive oxygen species. Ann Biomed Eng. 2013; 41: 3: 656. doi: 10.1007 / s10439-013-0740-7.][12. Choi BBR, Choi JH, Hong JW, Song KW, Lee HJ. Selective Killing of Melanoma Cells With Non-Thermal Atmospheric Pressure Plasma and p-FAK Antibody Conjugated Gold Nanoparticles. Int J Med Sci. 2017; 4: 14: 1101-1109. doi: 10.7150 / ijms.20104.][13. Robson MC, Heggers JP. Surgical infection. II. The beta-hemolytic streptococcus. J Surg Res. 1969; 9: 5: 289-292. doi: 10.1016 / 0022-4804 (69) 90068-7.][14. Fetyukov AI, Shornikov VA, Siccura AP, Avdeev EA, Petrova LA. Treatment of trophic ulcers in various forms of diabetic foot using cold plasma. Emergency medical care. 2004; 5: 3: 260-261. (In Russ.)][15. Chernyakhovskaya NE, Shishlo VK, Chomaeva AA, Shevkhuzhev ZA. 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J Dtsch Dermatol Ges. 2018; 16: 1: 7-13. doi: 10.1111 / ddg.13373.][21. Bernhardt T. Semmler ML, Schäfer M, Bekeschus S, Emmert S. Plasma Medicine: Applications of Cold Atmospheric Pressure Plasma in Dermatology. Oxid Med Cell Longev. 2019; 3: Index:3873928. doi: 10.1155 / 2019/3873928.]