Journal of Experimental and Clinical SurgeryJournal of Experimental and Clinical Surgery2070-478X2409-143XVoronezh State Medical University18010.18499/2070-478X-2015-8-1-82-86UnknownSubstantiation Study of Using Immobilized Cytostatics in Management of Tumors with Peritoneal CanceromatosisMD, prof., head of the department of oncology, Kursk State Medical University.kursk_ood@mail.ruPh.D., associate prof., department of oncology, Kursk State Medical University.kursk_ood@mail.ruPh.D., associate prof., department of oncology, Kursk State Medical University.kursk_ood@mail.ruthe head of the 1 st surgical department.kursk_ood@mail.ruMD, Prof., the head of the department of General Surgery, Kursk State Medical University.SukovatykhBS@kursksmu.netassistant prof., department of oncology, Kursk State Medical University.nixonfrol@mail.ruMD, prof., head of the department of polymer science and colloids, Voronezh State University.vms159@mail.ruMD, prof. of the department of polymer science and colloids, Voronezh State University.vms159@mail.rua surgeon of the department of oncology.kursk_ood@mail.ruKursk State Medical University, 3 K.Marksa Str., Kursk, 305041, Russian FederationKursk oncologic dispensary, 20 Pirogova Str., Kursk, 305035, Russian FederationVoronezh State University, 1 Universitetskaia Sq., Voronezh, 394006, Russian Federation240320158182862704201627042016Copyright © 2015, ., ., ., ., ., ., ., ., .2015Relevance Despite the certain successes in early diagnostics of oncological diseases a considerable number of patients with the late-stage diseases including peritoneal canceromatosis are identified at the initial examination. The cytoreductive surgeries accompanied with injuries of peritoneal mesothelium may promote commissure appearance, commissure-tumor conglomerate formation and may result in developing the acute adhesive intestinal obstruction against the background of peritoneal canceromatosis. The purpose of the study The purpose of the study is to investigate the interaction between “Lintex-Mesogel” (manufactured by “Lintex”, St. Petersburg) and chemotherapy preparations traditionally used in the treatment of peritoneal canceromatosis – Cisplatin, 5-ftuorouracil and Cyclophosphanum Materials and methods The physicochemical investigation of the interaction between “Lintex-Mesogel” and chemotherapy preparations– Cisplatin, 5-ftuorouracil and Cyclophosphanum has been conducted by the ultraviolet-visible spectroscopy and infrared spectroscopy. Results and their discussion The research proves the chemical inertness of “Lintex-Mesogel” that allows using the immobilized forms of cytostaticsin managing patients with peritoneal canceromatosisalong withthe simultaneous prevention of commissure formation Conclusions The immobilization of the preparations mentionedabove into the “Lintex-Mesogel” structure promotes the controlled release of medical products providing the prolongation of their antitumoral action. Key words Cytostatics, carboxymethylcellulose, peritoneal canceromatosis[1.Belyayev A.M., Bagnenko S.F., Rukhlyada N.V. Vnutribryushnaya khimioterapiya zlokachestvennykh opukholey bryushnoy polosti. [Intraperitoneal chemotherapy of malignant tumors of the abdominal cavity]. Monografiya. SPb .: «ELBI-SPb», 2007; 254.][2.Verbitskiy D.A. 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