Journal of Experimental and Clinical SurgeryJournal of Experimental and Clinical Surgery2070-478X2409-143XVoronezh State Medical University53710.18499/2070-478X-2010-3-3-191-200UnknownAbout the possibility and usage perspectives of biologically active suture materials with antimicrobial and complex effect in sugery (experimental trials)<span>doctor of medical Sciences, Professor, head of Department of General surgery of Tver state medical Academy</span>author@vestnik-surgery.com<span>PhD, associate Professor of General surgery of Tver state medical Academy</span>author@vestnik-surgery.com<span>resident of Tver oblast Oncology dispensary</span>author@vestnik-surgery.comTver state medical Academy24092010331912000405201604052016Copyright © 2010, ., ., .2010<p>«In vitro» experiment the antimicrobial properties of various kinds of biologically active threads (420 samples) were studied. Some of them were used «in vivo» experiment on 173 white rats using visual criteria, cytological and histological methods, electronic microscopy and tensionmetry to estimate the results of experiences. Presence of expressed and prolonged antimicrobial activity of threads containing doxycycline and ciprofloxacin was confirmed. It is established that presence in threads of doxycycline; the substance from germanium containing organic compounds group (GOC), doxycycline and GOC stimulates reparative processes in the wound model and fasten its healing. Results of the experimental researches allow to recommend suture materials with doxycycline and doxycycline and GOC to use in surgical practice.</p>biologically active suture materialsantimicrobial effectбиологически активные шовные материалыантимикробное действие[1. Adamyan A. A. [Modern dressings and sutures: results and experience in the creation and clinical application. Materials of III International conference "Modern approaches to development of effective dressings, suture materials and polymer implants".] M. 1998; 20-22.][2. Abramov, A. Y. [Modern abdominal trauma: dangers and complications. Wounds and wound infection. Materials IV all-Russian conference of General surgeons with international participation and Plenum of problem Commission “Infection in surgery”]. Yaroslavl 2007; 293-296.][3. In Places.In., Muryseva E. N., [In Timerbulatov.M. Lazarev D. N. Prevention of purulent-septic complications in surgery. ]M.:"Triada-X", 2003; 320.][4. Struchkov, Yu., Gorbachev I. V. [Prevention of suppuration of wounds after operations on the abdominal organs in patients of elderly and senile age. Wounds and wound infection. Materials IV all-Russian conference of General surgeons with international participation and Plenum of problem Commission “Infection in surgery”.]Yaroslavl 2007; 376-378.][5. Marco F, Vallez R, Gonzalez R. [study of the efficacy of Vicryl plus coated antibacterial suture in an animal model of orthopedic surgery. Surgeon To Infect] 2007; 8: 3: 359-365.][6. Mina H., Nichols M., [hotel rothenburger S. in vivo antibacterial efficacy of Monocryl plus suture (Poliglecaprone 25 With triclosan). Surgeon To Infect] 2007; 8: 2: 209-214.][7. Boris Pasternak, Ren, M., L. Andersen et al[. Doxycyclinecoated sutures improve mechanical strength of intestinal anastomoses. ]Int J Colorectal Dis.2007; 28.]