Journal of Experimental and Clinical SurgeryJournal of Experimental and Clinical Surgery2070-478X2409-143XVoronezh State Medical University7710.18499/2070-478X-2012-5-2-264-268UnknownThe assesement of blood aggregation in the treatement of choleperitonitis with sodium hypochloriteauthor@vestnik-surgery.comauthor@vestnik-surgery.comauthor@vestnik-surgery.comauthor@vestnik-surgery.comauthor@vestnik-surgery.comauthor@vestnik-surgery.com24062012522642682604201626042016Copyright © 2012, ., ., ., ., ., .2012Animals with choleperitonitis have a growth of erythrocytes stimulatory effect on platelets aggregation and sectetion and vice versa, accompanied by the increase of hematokrit and the decrease of erythrocytes deformability. In the treatment of animals in the control group the maximum decrease of MDA occurred at day 7, while in the experimental group – at day 3. The study of blood antiaggregatory properties in the suspension of platelets with thrombin on animals of control group and experimental group at days 1, 3 and 7 with respect to the samples of the platelet suspension in intact animals without thrombin shows the higher degree of blood aggregation inhibition on animals of experimental group. Such a mechanism suggests that the oxidative effect of sodium hypochlorite is not simply inactivate of thrombin receptor and loss of the thrombin effect. It is possible that, on the one hand, the suppression of platelets aggregation and, on the other hand, the effect of cyclooxygenase inhibition by sodium hypochlorite are caused by different types of modification of the platelets plasmatic membrane.aggregationbloodbile peritonitisагрегациякровьжелчный перитонит[1. Bagnenko S.F., Mosiagin V.B., Karpova E.A. Zhelchnyi peritonit kak oslozhnenie laparoskopicheskoi kholetsistektomii [Bile peritonitis as a complication of laparoscopic cholecystectomy]. 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