Metal Nanoparticle Effect on Regeneration of Experimental Wounds

The purpose of the study Effect of the suspensions of copper and zinc nanoparticles on regeneration of an experimental conditionally aseptic wound when applied locally. Materials and methods The research object was60 laboratory white rats; copper, zinc nanoparticles generated with the help of plasma technology as suspensions in isotonic sodium chloride solution. Modeling of a full-layer conditionally aseptic wound was carried out in the interscapular region with an area of 400 mm². In the work experimental, planimetric, microbiological and statistical research methods were used. Results and their discussion The change of the area of the conditionally aseptic wound in experimental animals, conditionally aseptic wound healing rate (in mm²/day), diurnal reduction of the area of experimental wounds (in %) in dynamics are analysed. In animals of the experimental group taken the treatment by the suspension of copper nanoparticles a fast healing of the wound surface was observed. During the whole period of the research the healing of the wound surface of the animals of the experimental group was more active than in case of the comparison group because of the absence of the reinfection, that is connected to the evident antibacterial action of copper nanoparticles. Under the influence of the suspension of zinc nanoparticles stimulation of wound regeneration, earlier complete healing was observed as well, but some animals had wound infection resulted in expansion of the wound surface. It confirms the evident regenerative action of zinc nanoparticles in case of an absence or low-grade antiseptic effect. Conclusion The analysis of healing rate of conditionally aseptic wounds, diurnal reduction of the area of experimental wounds in dynamics confirms the effect of copper and zinc nanoparticles as a suspension on soft tissue wound regeneration.

Nanoparticles, copper, zinc, experimental wound, regeneration