Fournier’s Gangrene: the Criteria for Diagnosis, Prognostic Factors, Complications and Mortality


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Abstract

The early diagnosis, prognosis, complications and mortality Fournier’s gangrene (FG) are discussed. The terms pre-hospital period with FG is amount of 8.0 ± 5.2 days. Cases of misdiagnosis are observed in 70% in the early stages of FG due to nonspecific clinical and laboratory picture, lack of awareness and alertness of doctors. Early diagnosis of FG is based on clinical and laboratory data of the picture. In order to timely diagnosis of FG is used scale laboratory indicators of necrotizing fasciitis (LRINEC), allowing suspect FG in doubtful cases. In diagnostically unclear cases FG used radiation methods. At the slightest suspicion on the FG made explorative operation, including express biopsy of soft tissues. The differential diagnosis is carried out in the early stages of FG with acute diseases anogenital region and is rarely used. As a prognostic criteria discussed the patient's age, the presence and nature of comorbid diseases, severity of the condition, the hospital admission dates, duration of preoperative period, necrosis area, metabolic parameters, the amount of remedial necrectomy, antibiotic regimen, hyperbaric oxygen therapy. For the systematic evaluation of the severity of the patient's condition and prognosis use different scoring systems. Many of the proposed prognostic criteria are controversial. The favorable prognosis in FG is entirely dependent on early diagnosis and timing of emergency surgery. Sepsis and its complications are the main causes of deaths. Mortality in the FG has been a steady downward trend, and is 22.3 ± 8.8%. Prevention of the FG is a timely treatment of infectious and inflammatory diseases of the urinary organs and their complications.

About the authors

Andrew Vladimirovich Prokhorov

D.D. Pletnev Moscow clinical hospital № 57

Author for correspondence.
Email: botex@rambler.ru

PhD, head of the department of ultrasound
diagnostics

Russian Federation, 51 3rdParkovaya Str., Moscow, 105425

References

  1. Aliev S.A., Aliev E.S. Gangrena Fournier – aktualnyie aspektyi staroy bolezni v svete sovremennyih predstavleniy o patogeneze. [Fournier's gangrene - actual aspects an old disease in the light of modern concepts of pathogenesis]. Vestnik hirurgii im. I.I. Grekova 2014; 2:122 – 126. (In Russian)
  2. Privolnev V.V. Gangrena Fournier. [Fournier's gangrene]. Meditsinskiy vestnik MVD 2013; 67(6):26 – 32. (In Russian)
  3. Timerbulatov V.M., Hasanov A.G., Timerbulatov M.V. Gangrena Fournier. [Fournier's gangrene]. Hirurgiya 2009; (3):26 – 28. (In Russian)
  4. Cherepanin A.I., Svetlov K.V., Chernov A.F., Barmin E.V. Drugoy vzglyad na «bolezn Fournier v praktike hirurga». [Another look at "Fournier's disease in the practice of the surgeon."]. Hirurgiya 2009; 10:47 – 50. (In Russian)
  5. Altarac S., Katušin D., Crnica S., Papeš D., Rajković Z., Arslani N. Fournier’s gangrene: etiology and outcome analysis of 41 patients. Urol. Int. 2012; 88(3):289-293.
  6. Ayan F., Sunamak O., Paksoy S.M., Polat S.S., As A., Sakoglu N., et al. Fournier's gangrene: a retrospective clinical study on forty-one patients. ANZ J. Surg. 2005; 75(12):1055-1058.
  7. Barreda J.T., Scheiding M.M., Fernandez C.S., Campaña C.J.M., Aguilera J.R., Miranda E.F., et al. Fournier’s gangrene. A retrospective study of 41 cases. Cir. Esp. 2010; 87(4):218-223.
  8. Benjelloun el B., Souiki T., Yakla N., Ousadden A., Mazaz K., Louchi A., et al. Fournier’s gangrene: our experience with 50 patients and analysis of factors affecting mortality. World J. Emerg. Surg. 2013; 8(13):1-5.
  9. Bruketa T., Majerovic M., Augustin G. Rectal cancer and Fournier’s gangrene - current knowledge and therapeutic options. World J. Gastroenterol. 2015; 21(30):9002–9020.
  10. Corcoran A.T., Smaldone M.C., Gibbons E.P., Walsh T.J., Davies B.J. Validation of the Fournier's gangrene severity index in a large contemporary series. Urol. 2008; 180(3):944-948.
  11. Chawla S.N., Gallop C., Mydlo J.H. Fournier's gangrene: an analysis of repeated surgical debridement. Eur. Urol. 2003; 43(5):572-575.
  12. Chennamsetty A., Khourdaji I., Burks F., Killinder K.A. Contemporary diagnosis and management of Fournier’s gangrene. Ther. Adv. Urol. 2015; 7(4):203-215.
  13. Eke N. Fournier’s gangrene: a review of 1726 cases. British. J. Surg. 2000; 87(6):85-87.
  14. Eskitaşcıoğlu T., Özyazgan I., Coruh A., Günay G.K., Altıparmak M., Yontar Y., et al. Experience of 80 cases with Fournier’s gangrene and “trauma” as a trigger factor in the etiopathogenesis. Ulus Travma Acil Cerrahi Derg. 2014; 20(4):265-274.
  15. Ghnnam W.M. Fournier’s gangrene in Mansoura Egypt: a review of 74 cases. J. Postgrad. Med. 2008; 54(2):106-109.
  16. Goh T., Goh L.G., Ang C.H., Wong H. Early diagnosis of necrotizing fasciitis. B.J.S. 2014; 101(1):119-125.
  17. Jerraya H., Fehri H., Khalfallah M., Abdesselem M.M., Dziri C. Predictive factors of mortality in Fournier's gangrene. Tunis Med. 2015; 93(12):800-803.
  18. Janane A., Hajji F., Ismail T.O., Chafiqui J., Ghadouane M., Ameur A., et al. Hyperbaric oxygen therapy adjunctive to surgical debridement in management of Fournier's gangrene: usefulness of a severity index score in predicting disease gravity and patient survival. Actas. Urol. Esp. 2011; 35(6):332-338.
  19. Kabay S., Yucel M., Yaylak F., Algin M.C., Hacioglu A., Kabay B., et al. The clinical features of Fournier’s gangrene and the predictivity of the Fournier’s Gangrene Severity Index on the outcomes. Int. Urol. Nephrol. 2008; 40(4):997-1004.
  20. Koukouras D., Kallidonis P., Panagopoulos C., Al-Aown A., Athanasopoulos A., Rigopoulos C., et al. Fournier’s gangrene, a urologic and surgical emergency: presentation of a multi-institutional experience with 45 cases. Urol. Int. 2011; 86:167-172.
  21. Korkut M., Içöz G., Dayangaç M., Akgün E., Yeniay L., Erdoğan O., et al. Outcome analysis in patients with Fournier’s gangrene: report of 45 cases. Dis. Colon Rectum 2003; 46(5): 649-652.
  22. Khamnuan P., Chongruksut W., Jearwattanakanok K., Patumanond J., Yodluangfun S., Tantraworasin A. Necrotizing fasciitis: risk factors of mortality. Risk Management and Healthcare Policy 2015; (8):1-7.
  23. Laor E., Palmer L.S., Tolia B.M., Reid R.E., Winter H.I. Outcome prediction in patients with Fournier’s gangrene. J. Urol. 1995; 154(1):89-92.
  24. Luján Marco S., Budía A., Di Capua C., Broseta E., Jiménez Cruz F. Evaluation of a severity score to predict the prognosis of Fournier's gangrene. BJU Int. 2010; 106(3):373-376.
  25. Mallikarjuna M.N., Vijayakumar A., Patiel V.S., Shivswamy B.S. Fournier’s gangrene: current practices. ISRN Surgery 2012; 2012:942437. doi: 10.5402/2012/942437. Epub 2012 Dec 3.
  26. Marin A.G., Riera C.N., Gil J.M., Fuentes F.T. Assessment of the Fournier’s Gangrene Severity Index Score with 34 patients. Am. Surg. 2011; 77(1):E5-6.
  27. McCormack M., Valiquette A.S., Ismail S. Fournier’s gangrene: A retrospective analysis of 26 cases in a Canadian hospital and literature review. Can. Urol. Assoc. J. 2015; 9(5-6):E407-E410.
  28. Mustafa Ali Korkut, Gökhan İçöz, Murat Dayangaç, Erhan Akgün, Levent Yeniay, Özgür Erdoğan, Çağ Çal. Outcome Analysis in Patients With Fournier's Gangrene Report of 45 Cases. Diseases of the Colon & Rectum 2003; 46(5):649-652
  29. McHenry C.R., Piotrowski J.J., Petrinic D. Determinants of mortality for necrotizing soft-tissue infections. Annals of Surgery 1995; 221(5):558-565.
  30. Oymacı E., Coşkun A., Yakan S., Erkan N., Uçar A.D., Yıldırım M. Evaluation of factors affecting mortality in Fournier's Gangrene: Retrospective clinical study of sixteen cases. Ulus Cerrahi Derg. 2014; 30(2):85-89.
  31. Puvanendran R., Huey J.C.M., Pasupathy S. Necrotizing fasciitis. Can. Fam. Physician 2009; 55(10):981-987.
  32. Rohan Khandelwal, Chintamani, Megha Tandon, Arjun Saradna A., Deepansh Gupta D., Bhavya Bahl B. Fournier’s gangrene severity index as a predictor of outcome in patients with Fournier’s gangrene: a prospective clinical study at a tertiary care center. J. Young Med. Res. 2013; 1(1):1-5.
  33. Roghmann F., von Bodman C., Löppenberg B., Hinkel A., Palisaar J., Noldus J. Is there a need for the Fournier's gangrene severity index? Comparison of scoring systems for outcome prediction in patients with Fournier's gangrene. BJU Int. 2012; 110(9):1359-1365.
  34. Saber A., Bajwa T.M. A simplified prognostic scoring system for Fournier’s gangrene. Urol. Nephrol. Open Access J. 2014; 1(3):1-4.
  35. Sarvestani A.M., Zamiri M., Sabouri M. Prognostic factors for Fournier’s gangrene; a 10-year experience in Southeastern Iran. Bull. Emerg. Trauma 2013; 1(3):116-122.
  36. Sabzi Sarvestani A., Zamiri M., Sabouri M. Prognostic factors for Fournier’s gangrene; a 10-year experience in Southeastern Iran. Bull. Emerg. Trauma 2013; l (3):116-122.
  37. Sallami S., Maalla R., Gammoudi A., Ben Jdidia G., Tarhouni L., Horchani A. Fournier's gangrene: what are the prognostic factors? Our experience with 40 patients. Tunis Med. 2012; 90(10):708-714.
  38. Sroczyński M., Sebastian M., Rudnicki J., Sebastian A., Agrawal A.K. A comlex approach to the treatment of Fournier’s gangrene. Adv. Clin. Exp. Med. 2013; 22(1):131-135.
  39. Smith G.L., Bunker C.B., Dinneen M.D. Fournier’s gangrene. British J. of Urol. 1998; 81:347-355.
  40. Sugihara T., Yasunaqa H., Horiquchi H., Fujimura T., Ohe K, Matsuda S., Fushimi K., et al. Impact of surgical intervention timing on the case fatality rate for Fournier’s gangrene: an analysis of 379 cases. BJU Int. 2012; 110(11 Pt C):E1096-1100.
  41. Sorensen M.D., Krieger J.N. Fournier's Gangrene: Epidemiology and Outcomes in the General US Population. Urol. Int. 2016 May 14. [Epub ahead of print].
  42. Thwaini A., Khan A., Malik A., Cherian J., Barua J., Shergill I, et al. Fournier’s gangrene and its emergency management Postgrad. Med. J. 2006; 82(970):516-519.
  43. Temiz M. Fournier’s gangrene. Emerg. Med. 2014; 4(3):1 – 2.
  44. Tuncel A., Aydin O., Tekdogan U., Nalcacioglu V., Capar Y., Atan A. Fournier's gangrene: Three years of experience with 20 patients and validity of the Fournier's Gangrene Severity Index Score. Eur. Urol. 2006; 50(4):838-843.
  45. Tarchouli M., Bounaim A., Essarghini M., Ratbi M.B., Belhamidi M.S., Bensal A., et al. Analysis of prognostic factors affecting mortality in Fournier's gangrene: A study of 72 cases. Can. Urol. Assoc. J. 2015; 9(11-12):E800-E804.
  46. Unalp H.R., Kamer E., Derici H., Atahan K., Balci U., Demirdoven C., et al. Fournier’s gangrene: evaluation of 68 patients and analysis of prognostic variables. J. Postgrad. Med. 2008; 54(2);102-105.
  47. Wang L., Han X., Liu M., Li B., Pan E., Li W., et al. Experience in management of Fournier’s gangrene: a report of 24 cases. J. Huazhong. Univ. Sci. Technolog. Med. Sci. 2012; 32(5):719-723.
  48. Wong C.H., Khin L.W., Heng K.S., Wong C.H., Khin L.W., Heng K.S., et al. The LRINEC (Laboratory Risk Indicator for Necrotizing Fasciitis) score: a tool for distinguishing necrotizing fasciitis from other soft tissue infections. Crit. Care Med. 2004; 32(7):1535-1541.
  49. Wróblewska M., Kuzaka B., Borkowski T., Kuzaka P., Kawecki D., Radziszewski P. Fournier’s gangrene – current concepts. Pol. J. Microbiol. 2014; 63(3):267-273.
  50. Yeniyol C.O., Suelozgen T., Arslan M., Ayder A.R. Fournier's gangrene: experience with 25 patients and use of Fournier's gangrene severity index score. Urology 2004; 64(2):218-222.
  51. Yilmazlar T., Ozturk E., Ozguc H., Ercan I., Vuruskan H., Oktay B. Fournier's gangrene: an analysis of 80 patients and a novel scoring system. Tech. Coloproctol. 2010; 14(3):217-223.
  52. Yılmazlar T., Işık Ö., Öztürk E., Özer A., Gülcü B., Ercan İ. Fournier's gangrene: review of 120 patients and predictors of mortality. Ulus. Travma Acil. Cerrahi. Derg. 2014; 20(5):333-337.
  53. Zhu X.D., Ding F., Wang G.D., Shao Q. Different scoring systems to evaluate the prognosis of Fournier's gangrene: A comparative study. Zhonghua. Nan. Ke. Xue. 2015; 21(8):720-723.

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