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Application of modified sodium hyaluronate with thrombin and miramistin for bleeding arrest in case of damage to parenchymal organs
- Authors: Fedoseev A.V.1, Inyutin A.S.1, Andrianov A.G.1, Antoshkin Y.A.1, Ershov A.A.1, Evdokimova O.V.1, Evseenkov O.V.2
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Affiliations:
- Ryazan State Medical University named after Academician I.P. Pavlov
- Joint Stock Company "Biopolimed"
- Issue: Vol 19, No 1 (2026)
- Pages: 14-21
- Section: Original articles
- URL: https://vestnik-surgery.com/journal/article/view/1859
- DOI: https://doi.org/10.18499/2070-478X-2026-19-1-14-21
- ID: 1859
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Abstract
Rationale. The issue of bleeding from acute wounds of parenchymal organs remains a pressing one, with liver injuries accounting for up to 25% of all abdominal trauma cases. The number of combat casualties is increasing. Severe blood loss is the primary cause of high mortality. Current options applied to stop parenchymal bleeding often fail to achieve effective hemostasis, necessitating the search for new, more advanced techniques to address this challenge.
The aim of the study was to evaluate the effectiveness of modified sodium hyaluronate combined with thrombin and miramistin as an option to stop bleeding from parenchymal organs.
Materials and methods. The study involved 10 laboratory pigs. Each animal was simulated three stage I liver wounds and three stage II spleen wounds, according to the validated scale for assessing the severity of intraoperative bleeding developed by Kevin M. Lewis et al. 2016; spleen wounds were determined as stage I spleen wounds according to the AAST (American Association for the Surgery of Trauma) spleen injury scale. Modified sodium hyaluronate with thrombin and miramistin was applied to the simulated liver and spleen wounds to study the hemostatic effect; the duration of bleeding, the volume of blood loss were considered hemostasis assessment criteria.
Results. After 20 minutes, the experiment results demonstrated that the rate of complete hemostasis was 4 times higher after application of modified sodium hyaluronate with thrombin and miramistin compared to a gauze pad, and 2 times compared to Tachocomb (trade name No. 167533), in case of acute liver wounds. Statistical analysis of the obtained data demonstrated a more significant hemostatic effect of sodium hyaluronate compared to both gauze and Tachocomb. Complete hemostasis was observed in 100% of cases after application of sodium hyaluronate to acute spleen wounds.
Conclusion. Thus, application of modified sodium hyaluronate with thrombin and miramistin to stop bleeding from acute wounds of the liver and spleen has a more pronounced hemostatic effect in terms of the number of complete hemostasis cases if compared with other local hemostatic agents.
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About the authors
Andrey V. Fedoseev
Ryazan State Medical University named after Academician I.P. Pavlov
Author for correspondence.
Email: hirurgiarzn@gmail.com
M.D., Head of the Department of General Surgery, Traumatology, and Orthopedics
Russian Federation, RyazanAleksandr S. Inyutin
Ryazan State Medical University named after Academician I.P. Pavlov
Email: aleksandr4007@rambler.ru
M.D., Professor, the Department of General Surgery, Traumatology, and Orthopedics
Russian Federation, RyazanAleksandr G. Andrianov
Ryazan State Medical University named after Academician I.P. Pavlov
Email: Alexandermed5639@mail.ru
Assistant of the Department of General Surgery, Traumatology, and Orthopedics
Russian Federation, RyazanYaroslav A. Antoshkin
Ryazan State Medical University named after Academician I.P. Pavlov
Email: hoogs@mail.ru
Assistant of the Department of General Surgery, Traumatology, and Orthopedics
Russian Federation, RyazanArtem A. Ershov
Ryazan State Medical University named after Academician I.P. Pavlov
Email: levniko137@gmail.com
Senior Lab Researcher, Department of General Surgery, Traumatology, and Orthopedics
Russian Federation, RyazanOlga V. Evdokimova
Ryazan State Medical University named after Academician I.P. Pavlov
Email: olartemyeva@yandex.ru
Ph.D., Associate Professor, Head of the Department of Microbiology
Russian Federation, RyazanOleg V. Evseenkov
Joint Stock Company "Biopolimed"
Email: oleg@evseenkov.ru
Manufacturer
Russian Federation, MoscowReferences
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