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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="other" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Journal of Experimental and Clinical Surgery</journal-id><journal-title-group><journal-title xml:lang="en">Journal of Experimental and Clinical Surgery</journal-title><trans-title-group xml:lang="ru"><trans-title>Вестник экспериментальной и клинической хирургии</trans-title></trans-title-group></journal-title-group><issn publication-format="print">2070-478X</issn><issn publication-format="electronic">2409-143X</issn><publisher><publisher-name xml:lang="en">Voronezh State Medical University named after N.N. Burdenko</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">114</article-id><article-id pub-id-type="doi">10.18499/2070-478X-2012-5-4-634-638</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Original articles</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Оригинальные статьи</subject></subj-group><subj-group subj-group-type="article-type"><subject>Unknown</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Optimization of antibacterial therapy in erysipelatous inflammation</article-title><trans-title-group xml:lang="ru"><trans-title>Оптимизация антибактериальной терапии при рожистом воспалении</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name><surname>Хасанов</surname><given-names>А.Г.</given-names></name><address><country country="RU">Russian Federation</country></address><bio><p>Хасанов Анвар Гиниятович – д.м.н., проф., зав. кафедрой хирургических болезней Башкирско- го государственного медицинского университета</p></bio><email>hasanovag@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name><surname>Шайбаков</surname><given-names>Д.Г.</given-names></name><address><country country="RU">Russian Federation</country></address><bio><p>Шайбаков Данис Габдинурович – к.м.н., доц. ка- федры хирургических болезней Башкирского госу- дарственного медицинского университета</p></bio><email>danis.com@yandex.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name><surname>Нигматзянов</surname><given-names>С.С.</given-names></name><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Нигматзянов Салим Салихович – к.м.н., асс. кафе- дры хирургических болезней Башкирского госу- дарственного медицинского университета</p></bio><bio xml:lang="ru"><p>Нигматзянов Салим Салихович – к.м.н., асс. кафе- дры хирургических болезней Башкирского госу- дарственного медицинского университета.</p></bio><email>Mail@Vestnik-surgery.com</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name><surname>Карамова</surname><given-names>Р.Ф.</given-names></name><address><country country="RU">Russian Federation</country></address><bio><p>Карамова Регина Фоатовна – аспирант кафедры хи- рургических болезней Башкирского государствен- ного медицинского университета.</p></bio><email>Mail@Vestnik-surgery.com</email><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff id="aff1"><institution>Башкирский государственный медицинский университет</institution></aff><pub-date date-type="pub" iso-8601-date="2012-12-24" publication-format="electronic"><day>24</day><month>12</month><year>2012</year></pub-date><volume>5</volume><issue>4</issue><issue-title xml:lang="ru"/><fpage>634</fpage><lpage>638</lpage><history><date date-type="received" iso-8601-date="2016-04-27"><day>27</day><month>04</month><year>2016</year></date><date date-type="accepted" iso-8601-date="2016-04-27"><day>27</day><month>04</month><year>2016</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2012, Voronezh N.N. Burdenko State Medical University</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2012, ФГБОУ ВО ВГМУ им. Н.Н. Бурденко Минздрава России</copyright-statement><copyright-year>2012</copyright-year><copyright-holder xml:lang="en">Voronezh N.N. Burdenko State Medical University</copyright-holder><copyright-holder xml:lang="ru">ФГБОУ ВО ВГМУ им. Н.Н. Бурденко Минздрава России</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://vestnik-surgery.com/journal/about/editorialPolicies</ali:license_ref></license></permissions><self-uri xlink:href="https://vestnik-surgery.com/journal/article/view/114">https://vestnik-surgery.com/journal/article/view/114</self-uri><abstract xml:lang="en"><p>Case histories of 217 patients who were hospitalized and underweat treatment at the surgical department of city clinical hospital № 8 (Ufa) during the period from 2005 to 2010 were investigated. The control group included 103 patients who received therapy according to the standards of providing medical aid envisaged for this pathology as well as symptomatic treatment and therapy for concomitant pathology. Antibacterial therapy was given to all patients. The main group under study consisted of 114 patients who received antibacterial therapy in our modification (the first subgroup received concomitant systemic enzymatic therapy the second subgroup received therapy in combination with intramuscular injections of oxytocin, the third subgroup received prolonged antibacterial therapy on the surface of lymphatic vessel endothelium. The use of systemic enzymotherapy, namely flogenzyme in combination with antibiotics at the beginning of the therapy course resulted in more rapid improvement in patients general condition (patients of the main group), decrease of body temperature, reduction of intoxication and normalization of laboratory findings. Among 40 patients who received antibacterial therapy concomitantly with systematic enzymotherapy by intramuscular injection of oxytocin no recurrences were observed during the period of 3 years. Lymphotropic antibacterial therapy of erysipelatous inflammation in all patients resulted in the decrease of body temperature, reduction of skin hyperemia and swelling that were observed on 2d - 3d day after treatment whereas in patients of the control group these indices were reduced only on the 5-th – 6-th day. The duration of in hospital treatment decreased on average by 3, 8 days.</p></abstract><trans-abstract xml:lang="ru"><p>Анализированы результаты лечения 217 больных с рожистым воспалением. В контрольную группу включены 103 больных, которые получали лечение в соответствии со стандартами медицинской помощи для данной патологии. Основную группу составили 114 пациентов, которым антибактериальная терапия проводилась в авторской модифи- кации (1-ая подгруппа – на фоне системной энзимотерапии, 2-ая подгруппа – антибактериальная терапия в сочета- нии с в/м введением окситоцина), 3 подгруппа - путем создания пролонгированной антибактериальной поверхности на эндотелии лимфатических сосудов). Применение препарата СЭТ Флогэнзима в комбинации с антибиотиками в начале лечения способствовало более быстрому улучшению общего состояния больных основной группы, снижению температуры тела, уменьшению интоксикации и нормализации показателей лабораторных исследований. Среди 40 больных, получавших антибактериальную терапию в сочетании с системной энзимотерапией внутримышечным введением окситоцина, в течении 3-х лет рецидивов не наблюдали. При лимфотропной антибиотикотерапии рожи- стого воспаления почти у всех больных основной группы температура тела, гиперемия кожи, отек уменьшались уже на 2-3-и сутки, тогда как у больных контрольной группы после общепринятой антибиотикотерапии эти показатели снижались только на 5-6-е сутки. Длительность стационарного лечения сокращалась в среднем на 3, 8 дня.</p></trans-abstract><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>1. Bednova V.N., Borisenko K.K., Novolotskaia T.I. i dr. An-</mixed-citation></ref><ref id="B2"><label>2.</label><mixed-citation>tibiotiki i khimioterapiia.[Antibiotics and chemotherapy] 1998; 8: 45-46.</mixed-citation></ref><ref id="B3"><label>3.</label><mixed-citation>2. Bukharin O.V., Usviatsov B.Ia. 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