Journal of Experimental and Clinical SurgeryJournal of Experimental and Clinical SurgeryВестник экспериментальной и клинической хирургии2070-478X2409-143XVoronezh State Medical University named after N.N. Burdenko125510.18499/2070-478X-2019-12-2-134-140Review of literatureОбзор литературыUnknownUnresolved issues of treatment of the early phase of acute destructive pancreatitisНерешенные вопросы лечения острого деструктивного панкреатита.https://orcid.org/0000-0003-4126-2886KulikovDmitrii ViktorovichКуликовДмитрий Викторович
Russian Federation

full-time graduate student of the Department of General surgery

очный аспирант кафедры общей хирургии Первого Санкт-Петербургского государственного медицинского университета им.акад. И.П. Павлова

ello4ka_08@mail.ruKorolkovAndrey YurievichКорольковАндрей Юрьевич
Russian Federation

M.D., head of the Department of surgery of the research Institute of surgery and emergency medicine

доктор медицинских наук, руководитель отдела хирургии НИИ хирургии и неотложной медицины Первого Санкт-Петербургского государственного медицинского университета им.акад. И.П. Павлова

korolkov.a@mail.ruMorozovVictor PetrovichМорозовВиктор Петрович
Russian Federation

M.D., head of the Department of General surgery

доктор медицинских наук, заведующий кафедрой общей хирургии Первого Санкт-Петербургского государственного медицинского университета им.акад. И.П. Павлова

morozov.vp@mail.ruVaganovAlexey AlexandrovichВагановАлексей Александрович
Russian Federation

assistant of the Department of General surgery

ассистент кафедры общей хирургии Первого Санкт-Петербургского государственного медицинского университета им.акад. И.П. Павлова

wellex07@gmail.comPavlov First Saint Petersburg State Medical UniversityПервый Санкт-Петербургский государственный медицинский университет им.акад. И.П. Павлова2903201912213414002122018Copyright ©; 2019, Kulikov D.V., Korolkov A.Y., Morozov V.P., Vaganov A.A.Copyright ©; 2019, Куликов Д.В., Корольков А.Ю., Морозов В.П., Ваганов А.А.2019Kulikov D.V., Korolkov A.Y., Morozov V.P., Vaganov A.A.Куликов Д.В., Корольков А.Ю., Морозов В.П., Ваганов А.А.http://creativecommons.org/licenses/by-nc-nd/4.0https://vestnik-surgery.com/journal/article/view/1255

The article presents a review and analysis of modern conceptions about the course of acute destructive pancreatitis, according to national and international recommendations. The problematic and perspective questions of treatment of this pathology are highlighted. The key directions of treatment of acute destructive pancreatitis are determined, according to the authors, requiring additional development.

В статье представлен обзор и анализ современных представления о течении острого деструктивного панкреатита, согласно национальным и международным рекомендациям. Выделены проблемные и перспективные вопросы лечения этой патологии. Определены ключевые направления лечения острого деструктивного панкреатита, по мнению авторов, требующие дополнительной разработки.

pancreatitisparapancreatitisdestructivenutritionпанкреатитдеструктивныйпарапакреатитнутритивная поддержка1. Destructive pancreatitis: the algorithm for diagnosis and treatment (The project is based on the materials of the IX All-Russian Congress of Physicians, September 20-22, 2000, Volgograd) // Consilium-medicum. – 2001. – Т. 3, №6.2. Pugaev A.V. Acute pancreatitis. - Moscow: Profil, 2007. - P. 335.3. Filimonov MI, Gelfand BR, Burnevitch S.Z. Acute pancreatitis: a manual for doctors / ed. V.S. Saveliev. - M .: A.N. Bakulev SCCS of RAMS, 2000. - 60. - P. 3.4. Shelest PV, Mironov VI Diagnostics and prognosis of clinical and morphological forms of acute destructive pancreatitis Siberian Medical Journal. - 2007. - №6. - C. 5-9.5. Bagnenko SF Treatment of acute pancreatitis at an early stage of the disease: Proc. allowance // SPb. Institute of First Aid to them. I. I. Janelidze / S.F. Bagnenko, N.V. Rukhlyada, A.D. Tolstoy [and others]. - St. Petersburg. - 2002. - P. 246. Daila M.M. A Guide to Immunopharmacology. Dale, JK Foromena / M .: Medicine, 1998. - P. 3327. Ermolov A.S. Immunological assessment of severity and prognosis of acute pancreatitis, Vest. Hir. - 2005. - №6. - P. 22-28.8. Eryukhina I.A. Surgical infections: leadership // IA. Eryukhina [and others] / M .; St. Petersburg; Peter, 2003. - P. 864.9. Tarasenko V.S. Diagnosis of suppurative complications of pancreatonecrosis. Tarasenko, D.B. Demin, D.V. Volkov [and others] / Urgent and specialized surgical care: first congress of Moskow surgeons. - M., 2005. - P. 114-115.10. Frey CF, Zhou H, Harvey DJ, et al. The incidence and case-fatality rates of acute biliary, alcoholic, and idiopathic pancreatitis in California, 1994-2001. Pancreas. – 2006. – 33. – P. 336–44.11. Nesvaderani M, Eslick GD, Vagg D, et al. Epidemiology, aetiology and outcomes of acute pancreatitis: a retrospective cohort study. Int J Surg. – 2015. – 23. – P. 68–74.12. Smith I, Ramesh J, Kyanam Kabir Baig KR, et al. Emerging role of endoscopic ultrasound in the Diagnostic evaluation of idiopathic pancreatitis. Am J Med Sci. – 2015. – 350. – P. 229–34.13. Yadav D, Lowenfels AB. Trends in the epidemiology of the first attack of acute pancreatitis: a systematic review. Pancreas. – 2006. – 33. – P. 323–30.14. National Clinical Recommendations for Acute Pancreatitis 2015 / Chairman Dibirov MD, Bagnenko SF, Blagovestnov DA, Galperin EI, Dyuzheva TG, Prudkov MI, Filimonov MI, Zhao AV. Access mode: Society-Surgeons.rf / stranica-pravlenija / unkr / urgentnaja-abdominalnaja-hirurgija / nacionalnye-klinicheskie-rekomendaci-po-ostromu-pankreatitu. - 2015. - P. 9.15. Kondratenko PG Acute pancreatitis / Kondratenko PG, Vasiliev AA, Konkova MV - Donetsk, 2008. - P. 352.16. Nakamura M., Takahashi M., Ohno K. et al. C-reactive protein concentration in dogs with various diseases. J. Vet. Med. Sci. - 2008. - P. 11.17. Vashetko R.V. Features of peritonitis in acute pancreatitis. / Vashetko RV, Ilyina VA, Boroday VA, Kremnev KS // Proceedings of the IX All-Russian Conference of General Surgeons with international participation "Peritonitis from A to Z" (All-Russian School), Yaroslavl, May 18-19, 2016.18. Rebrov A.A. Percutaneous minimally invasive operations under ultrasound in the treatment of patients with enzymatic peritonitis in acute pancreatitis of severe course. Rebrov AA, Semenov DY, Melnikov VV // Proceedings of the conference "Peritonitis from A to Z". - St. Petersburg. - 2013. - P. 367-369.19. Working Group IAP/APA (International Association of Pancreatology /American Pancreatic Association) Acute Pancreatitis Guidelines // Pancreatology - 2013. - 13. - Р. 1- 15.20. Kambhampati S., Park W., Habtezion A. Pharmacologic therapy for acute pancreatitis. //World J. Gastroenterol. 2014. - 20(45). – P. 16868-16880.21. Warndorf M.G., Kurtzman J.T., Bartel M.J. et al. Early fluid resuscitation reduces morbidity among patients with acute pancreatitis // Clin Gastroenterol Hepatol. 2011. – 9. – P. 705-709.22. Mao E.Q. Rapid hemodilution is associated with increased sepsis and mortality among patients with severe acute pancreatitis./ Mao E.Q., Fei J., Peng Y.B. et al. // Chin Med J (Engl). – 2010. - 123. – P. 1639 – 44.23. Wenbo M. Parenteral analgesics for pain relief in acute pancreatitis: A systematic review. Wenbo M., Jinqiu Y., Chuanlei Z. et al. // Pancreatology - 13. - 2013. - P. 201-206.24. Frolkov VV. Extended epidural blockade in complex intensive therapy of severe acute pancreatitis. Frolkov VV, Krasnoselsky MY, Ovechkin AM // Regional anesthesia and treatment of acute pain. - 2015. - No. 1. - P. 38-44.25. Windisch O. Thoracic epidural analgesia: a new approach for the treatment of acute pancreatitis? / O. Windisch, C.P. Heidegger, R. Giraud et al. // Crit Care. - 2016. - No. 20 (1). - P. 116.26. Clinical Trials.gov Identifier NCT02126332. Epidural Analgesia for Pancreatitis (Epipan Study).27. Katanov ES. Prevention of acute postoperative pancreatitis with epidural anesthesia // Ros. Jour. Gastroenterology, hepatology, coloproctology. - 1997.-№5. - P. 121-122.28. Makokha NS. Lumbar retroperitoneal blockade with novocaine with antibiotics and enzyme inhibitors in acute pancreatitis. Makokha NS, Kosolapov GS, Shirochenko ND, Serebryakov GI // Herald of surgery. -1976.- №9. - P. 23-26.29. Jiang K. Present and future of prophylactic antibiotics for severe acute pancreatitis./ Jiang K, Huang W, Yang XN, Xia Q. // World J Gastroenterol – 2012. - №18. – P. 279.30. Villatoro E. Antibiotic therapy for prophylaxis against infection of pancreatic necrosis in acute pancreatitis. / Villatoro E, Mulla M, Larvin M. // Cochrane Database Syst Rev – 2010. - №5. - CD002941.31. Piascik M. The results of severe acute pancreatitis treatment with continuous regional arterial infusion of protease inhibitor and antibiotic: a randomized controlled study./ Piascik M, Rydzewska G, Milewski J, Olszewski S, Furmanek M, Walecki J, et al. // Pancreas. – 2010.- 39:863e7.32. Rada G. Is antibiotic prophylaxis beneficial in acute pancreatitis: first update / Rada G., Peña J. // Medwave. — 2015. — Vol. 15, № 3. — e6125 doi:10.5867.33. Ammori B.J. Role of the gut in the course of severe acute pancreatitis // Pancreas. – 2003. – Vol. 26. – P. 122–129.34. Marik P.E. Meta-analysis of parenteral nutrition versus enteral nutrition in patients with acute pancreatitis / Marik P.E., Zaloga G.P. // BMJ. – 2004. – Vol. 328, – N 7453. – P. 1407.35. Petrov M.S. A systematic review on the timing of artificial nutrition in acute pancreatitis / Petrov M.S., Pylypchuk R.D., Uchugina A.F. // Br. J. Nutr. – 2009. – Vol. 101, N 6. – P. 787–793.36. Tolstoy A.D. Parapancreatitis (etiology, pathogenesis, diagnosis, treatment) / Tolstoy AD, Panov VP, Krasnorogov VB. - St. Petersburg: Clear Light, 2003. - P. 7.37. Gotzinger, P., Surgical treatment for severe acute pancreatitis: extent and surgical control of necrosis determine outcome. P. Gotzinger, World. J. Surg. 2009. - 26 (4) - P.474-8.38. Vashetko RV Morphology of local and general pathological processes in acute pancreatitis: Diss. Dr. med. Sciences - St. Petersburg, 1993. - P. 34839. Balldin G. The effect of peritoneal lavage and aprotinin in the treatment of severe acute pancreatitis./ Balldin G, Borgström A, Genell S, Ohlsson K. // Res Exp Med (Berl). – 1983. – 183. – P. 203–213.40. Berling R. Effects of high-dose intraperitoneal aprotinin treatment on complement activation and acute phase response in acute severe pancreatitis. / Berling R, Ohlsson K. // J Gastroenterol.- 1996. – 31. – P. 702–709.41. Ribacoff S. Study of the effect of trypsin inhibitor in acute hemorrhagic pancreatitis in dogs. / Ribacoff S., Hurwitz A., Khafif R., Siegman F. // Surg Forum. – 1961. - №12. – P. 370-372.42. Smith M. Aprotinin in severe acute pancreatitis./ Smith M, Kocher HM, Hunt BJ // Int J Clin Pract. – 2010. – 64. – P. 84–92.43. Trapnell J.E. A controlled trial of Trasylol in the treatment of acute pancreatitis./ Trapnell J.E., Rigby C.C., Talbot C.H., Duncan E.H. // Br J Surg. – 1974. – 61. – P. 177–182.44. Trapnell J.E. Proceedings: Aprotinin in the treatment of acute pancreatitis./ Trapnell J.E., Rigby C.C., Talbot C.H., Duncan E.H.// Gut. - 1973. – 14. – P. 828.