Journal of Experimental and Clinical SurgeryJournal of Experimental and Clinical SurgeryВестник экспериментальной и клинической хирургии2070-478X2409-143XVoronezh State Medical University named after N.N. Burdenko140110.18499/2070-478X-2020-13-3-279-284Review of literatureОбзор литературыUnknownApplication of Hydrogel Wound Dressings Combined with BacteriophagesИспользование гидрогелевых раневых покрытий в комбинации с бактериофагамиhttps://orcid.org/0000-0002-9332-3858BeschastnovVladimir ViktorovichБесчастновВладимир Викторович
Russian Federation

M.D., associate Professor, University clinic of the "PYM" the Ministry of health, senior researcher

д.м.н., доцент, Университетская клиника ФГБОУ ВО «ПИМУ» МЗ РФ, старший научный сотрудник

vvb748@mail.ruYudanovaTatiyana NikolaevnaЮдановаТатьяна Николаевна
Russian Federation

M.D., head of the laboratory of "New Dressing Materials" LLC

д.х.н., заведующая лабораторией ООО «Новые Перевязочные Материалы»

yudanova@voscopran.ruBegunStanislav MikhailovichБегунСтанислав Михайлович
Russian Federation

orthopaedic-traumatologist, University clinic of the Ministry of health of the Russian Federation

врач травматолог-ортопед, Университетская клиника ФГБОУ ВО «ПИМУ» МЗ РФ

begun.s.m@mail.ruLuzanAleksandr SergeevichЛузанАлександр Сергеевич
Russian Federation

traumatologist-orthopedist, University clinic of the Federal state educational INSTITUTION "PIMU" of the Ministry of health of the Russian Federation

врач травматолог-ортопед, Университетская клиника ФГБОУ ВО «ПИМУ» МЗ РФ

luzan.a.s@mail.ruhttps://orcid.org/0000-0002-9332-3858ShirokovaIrina YuryevnaШироковаИрина Юрьевна
Russian Federation

Ph.D., University clinic of the Federal state educational INSTITUTION "PIMU" of the Ministry of health of the Russian Federation, head of the laboratory research Department

к.м.н., Университетская клиника ФГБОУ ВО «ПИМУ» МЗ РФ, руководитель отдела лабораторных исследований

shirokova.i@yandex.ruhttps://orcid.org/0000-0002-8578-3600BelyaninaNatalia AleksandrovnaБелянинаНаталья Александровна
Russian Federation

Junior researcher, University clinic of the Federal state educational INSTITUTION "PIMU" of the Ministry of health of the Russian Federation

младший научный сотрудник, Университетская клиника ФГБОУ ВО «ПИМУ» МЗ РФ

belyaninanatasha@mail.ruhttps://orcid.org/0000-0003-0509-5988PavlenkoIlya ViktorovichПавленкоИлья Викторович
Russian Federation

Junior researcher, University clinic of the Federal state educational INSTITUTION "PIMU" of the Ministry of health of the Russian Federation

младший научный сотрудник, Университетская клиника ФГБОУ ВО «ПИМУ» МЗ РФ

ilyapavlenko@bk.ruhttps://orcid.org/0000-0001-6567-7803TulupovAleksandr AndreevichТулуповАлександр Андреевич
Russian Federation

Junior researcher

Младший научный сотрудник. Университетская клиника

tulupov.a.a@yandex.ruhttps://orcid.org/0000-0002-9332-3858LeontievAndrey EvgenievichЛеонтьевАндрей Евгеньевич
Russian Federation

Ph.D., associate Professor, research associate, University clinic of the Federal state educational INSTITUTION "PIMU" of the Ministry of health of the Russian Federation

к.м.н., доцент, Университетская клиника ФГБОУ ВО «ПИМУ» МЗ РФ, научный сотрудник

leontjeff@mail.ruNizhny Novgorod State Medical AcademyУниверситетская клиника ФГБОУ ВО «ПИМУ» МЗ РФ"New Dressing Materials" LLCООО «Новые Перевязочные Материалы»University clinic of the Ministry of health of the Russian FederationУниверситетская клиника ФГБОУ ВО «ПИМУ» МЗ РФUniversity clinic of the Federal state educational INSTITUTION "PIMU" of the Ministry of health of the Russian FederationУниверситетская клиника ФГБОУ ВО «ПИМУ» МЗ РФUniversity clinic of the Federal state educational INSTITUTION "PIMU" of the Ministry of health of the Russian FederationФедеральное государственное бюджетное образовательное учреждение высшего образования "Приволжский исследовательский медицинский университет" Министерства здравоохранения Российской Федерации2809202013327928419012020Copyright ©; 2020, Voronezh N.N. Burdenko State Medical UniversityCopyright ©; 2020, ФГБОУ ВО ВГМУ им. Н.Н. Бурденко Минздрава России2020Voronezh N.N. Burdenko State Medical UniversityФГБОУ ВО ВГМУ им. Н.Н. Бурденко Минздрава Россииhttps://vestnik-surgery.com/journal/about/editorialPolicieshttps://vestnik-surgery.com/journal/article/view/1401

Treatment of soft tissue wound defects, especially those with a tendency to a prolonged chronic course, is a serious problem. The increase in the number of local infectious complications after surgical interventions, including orthopedic and trauma ones, requires to search for new opportunities in solving the problem of prevention and treatment of acute and chronic surgical infection. The increase in the number of multi-resistant nosocomial microflora resistant to a wide range of modern antibacterial drugs, as well as the ability of some bacterial agents to form structured biofilm colonies under certain conditions, significantly complicates the work of surgeons. Phage therapy is a promising field in the treatment of infections that is being actively developed in Western Europe, the Asian region, and the United States. Based on the experience of foreign experts, the article describes possible options of bacteriophage interaction with hydrogels, ways of fixing phage particles in hydrogel-based wound dressings, and possible effective combinations of phages with other substances.

Лечение раневых дефектов мягких тканей, особенно со склонностью к затяжному хроническому течению представляется серьезной проблемой. Рост числа местных инфекционных осложнений после хирургических, в том числе ортопедических и травматологических вмешательств заставляет искать новые возможности в решении проблемы профилактики и лечения острой и хронической хирургической инфекции. Увеличение числа мультирезистентной нозокомиальной микрофлоры, устойчивой к большому спектру современных антибактериальных препаратов, а также способность некоторых бактериальных агентов организовываться при определенных условиях в структурированные колонии – биопленки, значительно осложняет работу специалистов хирургического профиля. Перспективным направлением в лечении инфекций, активно разрабатываемым в странах Западной Европы, азиатского региона, США, является фаготерапия. В статье на основе опыта зарубежных коллег описаны возможности взаимодействия бактериофагов с гидрогелями, способы фиксации частиц фага в гидрогелевых раневых покрытиях, возможные действенные комбинации фагов с другими веществами.

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