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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="review-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Journal of Experimental and Clinical Surgery</journal-id><journal-title-group><journal-title xml:lang="en">Journal of Experimental and Clinical Surgery</journal-title><trans-title-group xml:lang="ru"><trans-title>Вестник экспериментальной и клинической хирургии</trans-title></trans-title-group></journal-title-group><issn publication-format="print">2070-478X</issn><issn publication-format="electronic">2409-143X</issn><publisher><publisher-name xml:lang="en">Voronezh State Medical University named after N.N. Burdenko</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">1607</article-id><article-id pub-id-type="doi">10.18499/2070-478X-2022-15-4-354-361</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Review of literature</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Обзор литературы</subject></subj-group><subj-group subj-group-type="article-type"><subject>Review Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Negative Effects of Knee Replacement</article-title><trans-title-group xml:lang="ru"><trans-title>Негативные последствия эндопротезирования коленного сустава</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-1799-641X</contrib-id><name-alternatives><name xml:lang="en"><surname>Mansurov</surname><given-names>Jalolidin Sh.</given-names></name><name xml:lang="ru"><surname>Мансуров</surname><given-names>Джалолидин Шамсидинович</given-names></name></name-alternatives><address><country country="UZ">Uzbekistan</country></address><bio xml:lang="en"><p>Professor, Department of Traumatology, Orthopedics and MFS</p></bio><bio xml:lang="ru"><p>Профессор кафедры травматологии, ортопедии и ВПХ</p></bio><email>jalolmedic511@gmail.com</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-4585-5160</contrib-id><name-alternatives><name xml:lang="en"><surname>Tkachenko</surname><given-names>Aleksandr Nikolaevich</given-names></name><name xml:lang="ru"><surname>Ткаченко</surname><given-names>Александр Николаевич</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>MD, PhD, D.Sc., Professor of the Department of Traumotology and Orthopedic, Military Field Surgery</p></bio><bio xml:lang="ru"><p>д-р мед. наук, профессор, профессор кафедры травматологии, ортопедии и военно-полевой хирургии.</p></bio><email>altkachenko@mail.ru</email><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-8325-1937</contrib-id><contrib-id contrib-id-type="spin">2174-6400</contrib-id><name-alternatives><name xml:lang="en"><surname>Saiganov</surname><given-names>Sergey A.</given-names></name><name xml:lang="ru"><surname>Сайганов</surname><given-names>Сергей Анатольевич</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>MD, Dr. Sci. (Med.), Professor</p></bio><bio xml:lang="ru"><p>д.м.н., профессор</p></bio><email>rectorat@szgmu.ru</email><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-0754-4348</contrib-id><name-alternatives><name xml:lang="en"><surname>Khaidarov</surname><given-names>Valerii M.</given-names></name><name xml:lang="ru"><surname>Хайдаров</surname><given-names>Валерий Михайлович</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>MD, PhD, Assistant of the De-partment of Traumotology and Orthopedic, Military Field Surgery.</p></bio><bio xml:lang="ru"><p>к.м.н., ассистент кафедры травматологии, ортопедии и военно-полевой хирургии.</p></bio><email>drxaydarov@mail.ru</email><xref ref-type="aff" rid="aff3"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-4165-4599</contrib-id><name-alternatives><name xml:lang="en"><surname>Urazovskaya</surname><given-names>Irina L.</given-names></name><name xml:lang="ru"><surname>Уразовская</surname><given-names>Ирина Леонидовна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Phd., teacher of the department of hospital surgery and cardiology</p></bio><bio xml:lang="ru"><p>к.м.н., ассистент кафедры госпитальной хирургии и кардиологии</p></bio><email>langelova@yandex.ru</email><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-7744-0002</contrib-id><name-alternatives><name xml:lang="en"><surname>Tsololo</surname><given-names>Yaroslav B.</given-names></name><name xml:lang="ru"><surname>Цололо</surname><given-names>Ярослав Борисович</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Graduate student</p></bio><bio xml:lang="ru"><p>Аспирант</p></bio><email>yaroslav.tsololo@gmail.com</email><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-1985-5343</contrib-id><name-alternatives><name xml:lang="en"><surname>Baranovskii</surname><given-names>Aleksei A.</given-names></name><name xml:lang="ru"><surname>Барановский</surname><given-names>Алексей Александрович</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Orthopedic traumatologist</p></bio><bio xml:lang="ru"><p>Врач травматолог-ортопед</p></bio><email>dr.baranovsky@gmail.com</email><xref ref-type="aff" rid="aff4"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Samarkand State Medical University</institution></aff><aff><institution xml:lang="ru">Самаркандский государственный медицинский университет</institution></aff></aff-alternatives><aff-alternatives id="aff2"><aff><institution xml:lang="en">North-Western State Medical University named after I.I. Mechnikov</institution></aff><aff><institution xml:lang="ru">ФГБОУ ВО «Северо-Западный государственный медицинский университет им. И.И. Мечникова» Минздрава России</institution></aff></aff-alternatives><aff-alternatives id="aff3"><aff><institution xml:lang="en">North-Western  State  Medical  University  named  after  I.I.  Mechnikov</institution></aff><aff><institution xml:lang="ru">ФГБОУ ВО «Северо-Западный государственный медицинский университет им. И.И. Мечникова» Минздрава России</institution></aff></aff-alternatives><aff-alternatives id="aff4"><aff><institution xml:lang="en">City policlinic №51</institution></aff><aff><institution xml:lang="ru">ГБУЗ "Городская поликлиника №51"</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2022-12-31" publication-format="electronic"><day>31</day><month>12</month><year>2022</year></pub-date><volume>15</volume><issue>4</issue><issue-title xml:lang="ru"/><fpage>354</fpage><lpage>361</lpage><history><date date-type="received" iso-8601-date="2022-06-21"><day>21</day><month>06</month><year>2022</year></date><date date-type="accepted" iso-8601-date="2022-08-16"><day>16</day><month>08</month><year>2022</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2022, Voronezh N.N. Burdenko State Medical University</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2022, ФГБОУ ВО ВГМУ им. Н.Н. Бурденко Минздрава России</copyright-statement><copyright-year>2022</copyright-year><copyright-holder xml:lang="en">Voronezh N.N. Burdenko State Medical University</copyright-holder><copyright-holder xml:lang="ru">ФГБОУ ВО ВГМУ им. Н.Н. Бурденко Минздрава России</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://vestnik-surgery.com/journal/about/editorialPolicies</ali:license_ref></license></permissions><self-uri xlink:href="https://vestnik-surgery.com/journal/article/view/1607">https://vestnik-surgery.com/journal/article/view/1607</self-uri><abstract xml:lang="en"><p><bold>Introduction</bold> Total knee arthroplasty is the treatment of choice in orthopedic practice for patients with late –stage knee osteoarthritis. However, arthroplasty has not only benefit results and the service life of the endoprothesis is limited. The use of modern conservative therapy and joint-preserving surgions allowed to delay or to avoid knee arthroplasty.</p> <p><bold>Purpose.</bold> The study purpose is the analysis of publications with negative results of knee arthroplasty in patients with knee osteoarthritis.</p> <p><bold>Materials and methods.</bold> The electronic Pub-Med/MEDLINE and eLibrary databases were searched for reviews published between 2002 and 2022. A keyword search was also done using the terms: knee joint osteoarthritis, total knee replacement/arthroplasty, complications, patient satisfaction, indications/contraindications for surgery; related definitions and descriptions were extracted.</p> <p><bold>Results</bold>. The negative consequences of total knee arthroplasty are heterogeneous. Complications can be local and systemic such as surgical site infection, periprosthetic fracture, aseptic loosening (aseptic instability) of the endoprosthesis and its wear and the implant failure. The researcher’s data indicate increasing the number of patients who are not satisfied with the results of arthroplasty both in the short term and in the long-term after the operation, due to the natural wear of the prosthesis. Patients are not satisfied with the results of the operation 8% -30%. In recent years, there have been more publications devoted to the limitation of indication for arthroplasty in pftients with knee osteoarthritis. The replacement of the knee joint with an implant was done unreasonably in great number of cases.A number of patients after total knee arthroplasty require revision surgery within the first 5 years. Currently, the risk of failure of knee arthroplasty with the revision surgery in 10 years after primary arthroplasty is 5-6.8%. The main reasons for revision surgery after primary knee arthroplasty are periprosthetic infection and instability of the implant components, while the results of revision surgery are worse than the primary arthroplasty.</p></abstract><trans-abstract xml:lang="ru"><p>Актуальность. Тотальное эндопротезирование коленного сустава является операцией выбора в ортопедической практике для пациентов с поздней стадией остеоартрита коленного сустава. Однако результаты артропластики не всегда являются положительными, т.к. в ряде случаев возникают осложнения, к тому же срок службы эндопротеза ограничен. Применение современных консервативных технологий и органосохраняющих вмешательств позволяет отсрочить или избежать эндопротезирования коленного сустава. </p> <p>Цель исследования – провести анализ публикаций, посвященных неблагоприятным последствиям артропластики коленного сустава при остеоартрите. </p> <p>Материалы и методы. Проводился поиск данных литературы в открытых электронных базах научной литературы PubMed и еLIBRARY. Поиск осуществлялся по ключевым словам и словосочетаниям: остеоартрит коленного сустава, артропластика коленного сустава, осложнения, показания и противопоказания к артропластике коленного сустава. Глубина поиска составила 20 лет. </p> <p>Результаты. Негативные последствия тотального эндопротезирования коленного сустава неоднородны. Осложнения могут быть как местными, так и общими, такими, как инфекция области хирургического вмешательства, перипротезный перелом, асептическое расшатывание (асептическая нестабильность) эндопротеза и его износ, а также разрушение имплантата. Данные исследователей указывают на увеличение числа пациентов, не удовлетворенных результатами эндопротезирования как в краткосрочной, так и в долгосрочной перспективе после операции, из-за осложнений или естественного износа протеза. От 8% до 30% пациентов ожидали более значительного эффекта от операции. В последние годы выросло число публикаций, посвященных ограничению показаний к эндопротезированию при остеоартрите коленного сустава. Замена коленного сустава имплантатом в большом количестве случаев проводилась необоснованно. Ряд пациентов после тотальной артропластики коленного сустава уже в течение первых 5 лет нуждаются в ревизионном хирургическом вмешательстве. В настоящее время риск неэффективности эндопротезирования коленного сустава с потребностью в ревизионной операции через 10 лет после первичной артропластики составляет 5-6,8%. Основными причинами ревизионного хирургического вмешательства после первичного эндопротезирования КС являются перипротезная инфекция и нестабильность компонентов импланта, при этом результаты ревизионных вмешательств уступают исходам первичной артропластики. </p> <p> </p></trans-abstract><kwd-group xml:lang="en"><kwd>knee joint osteoarthritis</kwd><kwd>total knee replacement/arthroplasty</kwd><kwd>complications</kwd><kwd>patient satisfaction</kwd><kwd>indications/contraindications for surgery</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>остеоартрит коленного сустава</kwd><kwd>тотальное эндопротезирование коленного сустава</kwd><kwd>осложнения, удовлетворенность пациентов</kwd><kwd>показания/противопоказания к операции</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><citation-alternatives><mixed-citation xml:lang="en">Sebbag E, Felten R, Sagez F, Sibilia J, Devilliers H, Arnaud L. 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