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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="review-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Journal of Experimental and Clinical Surgery</journal-id><journal-title-group><journal-title xml:lang="en">Journal of Experimental and Clinical Surgery</journal-title><trans-title-group xml:lang="ru"><trans-title>Вестник экспериментальной и клинической хирургии</trans-title></trans-title-group></journal-title-group><issn publication-format="print">2070-478X</issn><issn publication-format="electronic">2409-143X</issn><publisher><publisher-name xml:lang="en">Voronezh State Medical University named after N.N. Burdenko</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">1640</article-id><article-id pub-id-type="doi">10.18499/2070-478X-2023-16-1-90-97</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Review of literature</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Обзор литературы</subject></subj-group><subj-group subj-group-type="article-type"><subject>Review Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Hepatolithiasis</article-title><trans-title-group xml:lang="ru"><trans-title>Гепатиколитиаз</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-3887-4785</contrib-id><name-alternatives><name xml:lang="en"><surname>Marinova</surname><given-names>Lyudmila Anatolievna</given-names></name><name xml:lang="ru"><surname>Маринова</surname><given-names>Людмила Анатольевна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Cand. of Med. Sci., Head of the Interventional Endoscopy Group</p></bio><bio xml:lang="ru"><p>кандидат медицинских наук, руководитель группы интервенционной эндоскопии</p></bio><email>lmarinova@bk.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-8053-7913</contrib-id><name-alternatives><name xml:lang="en"><surname>Baydarova</surname><given-names>Marina Dakhirovna</given-names></name><name xml:lang="ru"><surname>Байдарова</surname><given-names>Марина Дахировна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Cand. of Med. Sci., junior research fellow of the Interventional Endoscopy Group</p></bio><bio xml:lang="ru"><p>кандидат медицинских наук, младший научный сотрудник группы интервенционной эндоскопии</p></bio><email>marinabaydarova@yandex.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-6642-0663</contrib-id><name-alternatives><name xml:lang="en"><surname>Makatova</surname><given-names>Benevsha Iliyasovna</given-names></name><name xml:lang="ru"><surname>Макатова</surname><given-names>Беневша Ильясовна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Resident of the Interventional Endoscopy Group</p></bio><bio xml:lang="ru"><p>Ординатор группы интервенционной эндоскопии</p></bio><email>interendoixv@yandex.ru</email><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-9589-6086</contrib-id><name-alternatives><name xml:lang="en"><surname>Titov</surname><given-names>Georgy Sergeevich</given-names></name><name xml:lang="ru"><surname>Титов</surname><given-names>Георгий Сергеевич</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>resident of the Interventional Endoscopy Group</p></bio><bio xml:lang="ru"><p>ординатор группы интервенционной эндоскопии</p></bio><email>interendoixv@yandex.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-5958-3608</contrib-id><name-alternatives><name xml:lang="en"><surname>Gurmikov</surname><given-names>Beslan Nuralievich</given-names></name><name xml:lang="ru"><surname>Гурмиков</surname><given-names>Беслан Нуралиевич</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Cand. of Med. Sci., surgeon of the Oncological Department of Surgical Methods of Treatment</p></bio><bio xml:lang="ru"><p>кандидат медицинских наук, доцент образовательного отдела, врач-хирург онкологического отделения хирургических методов лечения</p></bio><email>gurmikov@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">A.V. Vishnevsky National Medical Scientific Centre of Surgery</institution></aff><aff><institution xml:lang="ru">Национальный медицинский исследовательский центр хирургии им. А.В.Вишневского</institution></aff></aff-alternatives><aff-alternatives id="aff2"><aff><institution xml:lang="en">A.V. Vishnevsky National Medical Scientific Centre of Surgery</institution></aff><aff><institution xml:lang="ru">Национальный медицинский исследовательский центр хирургии им. А.В. Вишневского</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2023-03-31" publication-format="electronic"><day>31</day><month>03</month><year>2023</year></pub-date><volume>16</volume><issue>1</issue><issue-title xml:lang="ru"/><fpage>90</fpage><lpage>97</lpage><history><date date-type="received" iso-8601-date="2022-08-11"><day>11</day><month>08</month><year>2022</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2023, Marinova L.A., Baydarova M.D., Makatova B.I., Titov G.S., Gurmikov B.N.</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2023, Маринова Л.А., Байдарова М.Д., Макатова Б.И., Титов Г.С., Гурмиков Б.Н.</copyright-statement><copyright-year>2023</copyright-year><copyright-holder xml:lang="en">Marinova L.A., Baydarova M.D., Makatova B.I., Titov G.S., Gurmikov B.N.</copyright-holder><copyright-holder xml:lang="ru">Маринова Л.А., Байдарова М.Д., Макатова Б.И., Титов Г.С., Гурмиков Б.Н.</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">http://creativecommons.org/licenses/by-nc-nd/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://vestnik-surgery.com/journal/article/view/1640">https://vestnik-surgery.com/journal/article/view/1640</self-uri><abstract xml:lang="en"><p>Hepatolithiasis is a disease characterized by intrahepatic stone formation, being a challenging disorder with frequent recurrences, development of chronic cholangitis and sepsis, as well as liver abscesses. Notably, without prompt and adequate treatment, hepatolithiasis is associated with the development of cirrhosis of the liver and cholangiocellular carcinoma. Recent reports demonstrate an increasing prevalence of hepatolithiasis, likely due to increased immigration and alterations in the Western diet. There is no clear algorithm for treatment of hepatolithiasis; the major treatment options are still removal of stones, correction of strictures associated with them and prevention of recurrence of cholangitis. The method of choice for hepatolithiasis is endoscopic and percutaneous interventions, in case of their failure open operations are performed in different volumes. However, data on the effectiveness of interventions, frequency of complications and relapses vary significantly according to various researchers. The authors analyse data on the above issue.</p></abstract><trans-abstract xml:lang="ru"><p>Гепатиколитиаз характеризуется образованием конкрементов во внутрипеченочных желчных протоках и является трудноизлечимым заболеванием с частыми рецидивами, развитием хронического холангита и сепсиса, а также абсцессов печени. Кроме того, при отсутствии своевременно начатого и адекватного лечения на фоне гепатиколитиаза нередко развивается цирроз печени, а также внутрипеченочный холангиоцеллюлярный рак. Недавние исследования свидетельствуют о растущей распространенности гепатиколитиаза, что, вероятнее всего, связано с ростом миграции и изменениями в рационе питания на Западе. Золотым стандартом неинвазивной диагностики гепатиколитиаза является магнитно-резонансная холангиопанкреатография, которая значимо превосходит компьютерную томографию с внутривенным контрастированием и ультразвуковое исследование брюшной полости при визуализации внутрипротоковых конкрементов и стриктур желчных протоков.</p> <p>Основными принципами в лечении гепатиколитиаза являются извлечение конкрементов, коррекция связанных с ними стриктур и профилактика рецидива холангита. Методом выбора при гепатиколитиазе являются эндоскопические и чрескожные вмешательства, при безуспешности которых выполняются хирургические операции в различном объеме. Однако сведения по эффективности вмешательств, частоте развития осложнений и рецидивов по данным разных авторов значимо отличаются.</p> <p>Выполнен анализ литературы по данной проблеме.</p></trans-abstract><kwd-group xml:lang="en"><kwd>hepatolithiasis</kwd><kwd>recurrent pyogenic cholangitis</kwd><kwd>peroral cholangioscopic lithotomy</kwd><kwd>percutaneous transhepatic cholangioscopic lithotomy</kwd><kwd>hepatectomy</kwd><kwd>liver transplant.</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>гепатиколитиаз</kwd><kwd>рецидивирующий пиогенный холангит</kwd><kwd>пероральная холангиоскопическая литотомия</kwd><kwd>чрескожная чреспеченочная холангиоскопическая литотомия</kwd><kwd>резекция печени</kwd><kwd>трансплантация печени</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><citation-alternatives><mixed-citation xml:lang="en">Zhao AV, Marinova LA, Baydarova MD, Trifonov SA. 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