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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="research-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Journal of Experimental and Clinical Surgery</journal-id><journal-title-group><journal-title xml:lang="en">Journal of Experimental and Clinical Surgery</journal-title><trans-title-group xml:lang="ru"><trans-title>Вестник экспериментальной и клинической хирургии</trans-title></trans-title-group></journal-title-group><issn publication-format="print">2070-478X</issn><issn publication-format="electronic">2409-143X</issn><publisher><publisher-name xml:lang="en">Voronezh State Medical University named after N.N. Burdenko</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">1685</article-id><article-id pub-id-type="doi">10.18499/2070-478X-2023-16-2-140-149</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Original articles</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Оригинальные статьи</subject></subj-group><subj-group subj-group-type="article-type"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Options for Two-Stage Extensive Liver Resections in the Surgical Treatment of Advanced Liver Echinococcosis</article-title><trans-title-group xml:lang="ru"><trans-title>Методики двухэтапных обширных резекций печени в хирургическом лечении распространенного эхинококкоза печени</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-7617-6422</contrib-id><contrib-id contrib-id-type="spin">9815-2782</contrib-id><name-alternatives><name xml:lang="en"><surname>Krasnov</surname><given-names>Arksdiy Olegovich</given-names></name><name xml:lang="ru"><surname>Краснов</surname><given-names>Аркадий Олегович</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>PhD, Surgeon</p></bio><bio xml:lang="ru"><p>кандидат медицинских наук, врач-хирург</p></bio><email>aokrasnov@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-1178-5205</contrib-id><contrib-id contrib-id-type="spin">9952-8041</contrib-id><name-alternatives><name xml:lang="en"><surname>Anishchenko</surname><given-names>Vladimir Vladimirovich</given-names></name><name xml:lang="ru"><surname>Анищенко</surname><given-names>Владимир Владимирович</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Doctor of Medical Sciences, Professor; Head of the Department of Surgery, Faculty of Advanced medical</p></bio><bio xml:lang="ru"><p>Доктор медицинских наук, профессор; заведующий кафедрой хирургии факультета усовершенствования врачей</p></bio><email>avv1110@yandex.ru</email><xref ref-type="aff" rid="aff2"/><xref ref-type="aff" rid="aff3"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-2216-1545</contrib-id><contrib-id contrib-id-type="spin">9715-2432</contrib-id><name-alternatives><name xml:lang="en"><surname>Pachgin</surname><given-names>Igor Vadimovich</given-names></name><name xml:lang="ru"><surname>Пачгин</surname><given-names>Игорь Вадимович</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>candidate of medical sciences; Chief Medical Officer</p></bio><bio xml:lang="ru"><p>кандидат медицинских наук; главный врач</p></bio><email>pachgin@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-9262-3656</contrib-id><contrib-id contrib-id-type="spin">3758-1502</contrib-id><name-alternatives><name xml:lang="en"><surname>Krasnov</surname><given-names>Konstantin Arkadyevich</given-names></name><name xml:lang="ru"><surname>Краснов</surname><given-names>Константин Аркадьевич</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>candidate of medical sciences; Deputy Chief Physician for Surgery and Transplant Care, Assistant Professor of Hospital Surgery</p></bio><bio xml:lang="ru"><p>кандидат медицинских наук; заместитель главного врача по хирургии и трансплантологической помощи, доцент кафедры госпитальной хирургии</p></bio><email>krasnov8k@rambler.ru</email><xref ref-type="aff" rid="aff4"/><xref ref-type="aff" rid="aff5"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-8230-6676</contrib-id><contrib-id contrib-id-type="spin">5450-6477</contrib-id><name-alternatives><name xml:lang="en"><surname>Pel'ts</surname><given-names>Vladislav Aleksandrovich</given-names></name><name xml:lang="ru"><surname>Пельц</surname><given-names>Владислав Александрович</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Candidate of Medical Sciences, Head of the Surgical Department, Associate Professor of the Department of Hospital Surgery</p></bio><bio xml:lang="ru"><p>кандидат медицинских наук, заведующий хирургическим отделением, доцент кафедры госпитальной хирургии</p></bio><email>vpelc_1@rambler.ru</email><xref ref-type="aff" rid="aff1"/><xref ref-type="aff" rid="aff5"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-5214-7771</contrib-id><contrib-id contrib-id-type="spin">4672-6564</contrib-id><name-alternatives><name xml:lang="en"><surname>Krasnov</surname><given-names>Oleg Arkadyevich</given-names></name><name xml:lang="ru"><surname>Краснов</surname><given-names>Олег Аркадьевич</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Doctor of Medical Sciences; Professor of the Department of Faculty Surgery, Head of the Clinic</p></bio><bio xml:lang="ru"><p>доктор медицинских наук; профессор кафедры факультетской хирургии, заведующий поликлиникой</p></bio><email>xo1@mail.ru</email><xref ref-type="aff" rid="aff5"/><xref ref-type="aff" rid="aff6"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-9439-2049</contrib-id><contrib-id contrib-id-type="spin">5629-0576</contrib-id><name-alternatives><name xml:lang="en"><surname>Pavlenko</surname><given-names>Vladimir Vyacheslavovich</given-names></name><name xml:lang="ru"><surname>Павленко</surname><given-names>Владимир Вячеславович</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Doctor of Medical Sciences, Professor, Head of the Department of Hospital Surgery, Deputy Chief Physician for Scientific Activities</p></bio><bio xml:lang="ru"><p>доктор медицинских наук, профессор, заведующий кафедрой госпитальной хирургии, заместитель главного врача по научной деятельности</p></bio><email>pavlenkovv@list.ru</email><xref ref-type="aff" rid="aff5"/><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Kuzbass Clinical Emergency Hospital named after M. A. Podgorbunsky</institution></aff><aff><institution xml:lang="ru">Кузбасская клиническая больница скорой медицинской помощи имени М. А. Подгорбунского</institution></aff></aff-alternatives><aff-alternatives id="aff2"><aff><institution xml:lang="en">Novosibirsk State Medical University</institution></aff><aff><institution xml:lang="ru">Новосибирский государственный медицинский университет</institution></aff></aff-alternatives><aff-alternatives id="aff3"><aff><institution xml:lang="en">Avicenna Clinical Hospital of the Mother and Child Group of Companies</institution></aff><aff><institution xml:lang="ru">клинический госпиталь «Авиценна» группы компаний «Мать и дитя»</institution></aff></aff-alternatives><aff-alternatives id="aff4"><aff><institution xml:lang="en">Kuzbass Clinical Emergency Hospital named after M. A. Podgorbunsky</institution></aff><aff><institution xml:lang="ru">Кузбасская клиническая больница скорой медицинской помощи имени М.А.Подгорбунского</institution></aff></aff-alternatives><aff-alternatives id="aff5"><aff><institution xml:lang="en">Kemerovo State Medical University</institution></aff><aff><institution xml:lang="ru">Кемеровский государственный медицинский университет</institution></aff></aff-alternatives><aff-alternatives id="aff6"><aff><institution xml:lang="en">Kolpinsky Clinical Advisory Diagnostic Center</institution></aff><aff><institution xml:lang="ru">Клинический консультативный диагностический центр имени И.А. Колпинского</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2023-06-29" publication-format="electronic"><day>29</day><month>06</month><year>2023</year></pub-date><volume>16</volume><issue>2</issue><issue-title xml:lang="ru"/><fpage>140</fpage><lpage>149</lpage><history><date date-type="received" iso-8601-date="2022-12-29"><day>29</day><month>12</month><year>2022</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2023, Voronezh N.N. Burdenko State Medical University</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2023, ФГБОУ ВО ВГМУ им. Н.Н. Бурденко Минздрава России</copyright-statement><copyright-year>2023</copyright-year><copyright-holder xml:lang="en">Voronezh N.N. Burdenko State Medical University</copyright-holder><copyright-holder xml:lang="ru">ФГБОУ ВО ВГМУ им. Н.Н. Бурденко Минздрава России</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://vestnik-surgery.com/journal/about/editorialPolicies</ali:license_ref></license></permissions><self-uri xlink:href="https://vestnik-surgery.com/journal/article/view/1685">https://vestnik-surgery.com/journal/article/view/1685</self-uri><abstract xml:lang="en"><p>Introduction. The major and effective option for the treatment of liver echinococcosis are surgical operations. To choose a type of surgical intervention in a common form of liver echinococcosis under suspected deficit in the functional reserves of the organ and developing post-resection liver failure remains challenging.The aim of the study is to present and analyze the effectiveness of two-stage extensive resection interventions in patients with advanced liver echinococcosis.Materials and methods. The study included clinical findings of 24 patients with advanced liver echinococcosis (9/37.5% men, 15/62.5% women) who underwent surgical treatment in Surgical Department №2, “Kuzbass Clinical Emergency Hospital named after M. A. Podgorbunsky " (Kemerovo). The use of a two-stage major resection protocol was the criterion for inclusion in the study. Stage I was aimed to achieve vicarious hypertrophy of the contralateral lobe using various techniques to stop blood flow along the right branch of the portal vein. A two-stage protocol for extensive resection intervention was applied due to insufficient functional liver reserves and the small volume of the potential remnant; this resulted in the inability to safely use a single-stage extensive resection due to the predicted developing post-resection liver failure and a likely lethal outcome.Results and discussions. The applied surgical stage approaches for prevention of post-resection liver failure are effective due to the following parameters: CT volumetry (p&lt;0.05), residual concentration of indocyanine green at the 15th minute (p&lt;0.05), statistical model value (p&lt;0, 05). The level of effectiveness of the above technique is comparable with the laparotomic ligation of the right branch of the portal vein; however, the laparoscopic option is less traumatic, which can significantly reduce postoperative hospital stay (p&lt;0.05). In addition, there were no specific and nonspecific complications registered in case of the laparoscopic option.Conclusion. Two-stage extensive resection interventions for advanced liver echinococcosis are effective and sufficiently safe when operations are performed in specialized hepatological centers using a comprehensive protocol for preoperative examination. They can be recommended in case of the initial significant deficit in the volume of the potential liver remnant and functional reserves of the organ.</p></abstract><trans-abstract xml:lang="ru"><p>Актуальность. Основным методом лечения больных эхинококкозом печени является хирургический. Проблема выбора характера оперативного вмешательства при распространенной форме эхинококкоза печени в условиях предполагаемого дефицита функциональных резервов органа и развития пострезекционной печеночной недостаточности остается актуальной. Цель исследования. Представить и проанализировать эффективность двухэтапных обширных резекционных вмешательств у пациентов с распространенным эхинококкозом печени. Материалы и методы. В статье представлены результаты хирургического лечения 24 пациентов (9/37,5% мужчин, 15/62,5% женщин), оперированных в хирургическом отделении №2 ГАУЗ «ККБСМП им. М.А. Подгорбунского» (г. Кемерово) по поводу распространенного эхинококкоза печени. Критерием включения в исследование было применение протокола двухэтапного обширного резекционного вмешательства. В качестве I этапа применялись методики прекращения кровотока по правой ветве воротной вены с целью достижения викарной гипертрофии контрлатеральной доли. Причиной применения двухэтапного протокола резекционного обширного вмешательства были недостаточные функциональные резервы печени и малый объем предполагаемого ремнанта, а следовательно, отсутствие возможности безопасного применения одноэтапной обширной резекции, в связи с прогнозируемым развитием пострезекционной печеночной недостаточности и вероятного летального исхода. Результаты и обсуждения. Применяемые хирургические этапные методы профилактики пострезекционной печеночной недостаточности эффективны в отношении следующих показателей: КТ-волюметрия (p&lt;0,05), остаточная концентрация индоцианина зеленого на 15-й минуте (p&lt;0,05), значение статистической модели (p&lt;0,05). При сопоставимом уровне эффективности с лапаротомным методом перевязки правой ветви воротной вены лапароскопический метод является менее травматичным, что позволяет значимо сократить послеоперационное пребывание пациента в стационаре (p&lt;0,05). Так же при лапароскопическом варианте не зарегистрировано специфических и неспецифических осложнений. Заключение. Двухэтапные обширные резекционные вмешательства при распространенном эхинококкозе печени эффективны и в достаточной степени безопасны при выполнении операций в специализированных гепатологических центрах с применением углубленного протокола предоперационного обследования и могут быть рекомендованы к выполнению при исходном значимом дефиците объёма будущего ремнанта печени и функциональных резервов органа.</p></trans-abstract><kwd-group xml:lang="en"><kwd>widespread liver echinococcosis</kwd><kwd>two-stage extensive resections</kwd><kwd>treatment efficiency</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>распространенный эхинококкоз печени</kwd><kwd>двухэтапные обширные резекции</kwd><kwd>эффективность лечения</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Baimakhanov Z, Kaniyev S, Serikuly E, Doskhanov M, Askeyev B, Baiguissova D, Skakbayev, A, Sadykov C, Barlybay R, Seisembayev, M, Baimakhanov, B. 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