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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="review-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Journal of Experimental and Clinical Surgery</journal-id><journal-title-group><journal-title xml:lang="en">Journal of Experimental and Clinical Surgery</journal-title><trans-title-group xml:lang="ru"><trans-title>Вестник экспериментальной и клинической хирургии</trans-title></trans-title-group></journal-title-group><issn publication-format="print">2070-478X</issn><issn publication-format="electronic">2409-143X</issn><publisher><publisher-name xml:lang="en">Voronezh State Medical University named after N.N. Burdenko</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">1716</article-id><article-id pub-id-type="doi">10.18499/2070-478X-2024-17-1-41-50</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Review of literature</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Обзор литературы</subject></subj-group><subj-group subj-group-type="article-type"><subject>Review Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Factors Affecting the Results of the Experiment in the Perioperative Period</article-title><trans-title-group xml:lang="ru"><trans-title>Факторы, влияющие на результаты эксперимента в периоперационном периоде</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Morozov</surname><given-names>Artem M.</given-names></name><name xml:lang="ru"><surname>Морозов</surname><given-names>Артем Михайлович</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Ph.D., Associate Professor, Associate Professor of the Department of General Surgery </p></bio><bio xml:lang="ru"><p>к.м.н., доцент, доцент кафедры общей хирургии</p></bio><email>ammorozovv@gmail.com</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Sergeev</surname><given-names>Alexey N.</given-names></name><name xml:lang="ru"><surname>Сергеев</surname><given-names>Алексей Николаевич</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>M.D., Associate Professor, Head of the Department of General Surgery</p></bio><bio xml:lang="ru"><p>д.м.н., доцент, заведующий кафедрой общей хирургии</p></bio><email>dr.nikolaevich@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Askerov</surname><given-names>Elshad M.</given-names></name><name xml:lang="ru"><surname>Аскеров</surname><given-names>Эльшад Магомедович</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>M.D., Associate Professor, Head of the Department of General Surgery</p></bio><bio xml:lang="ru"><p>к.м.н., доцент, доцент кафедры общей хирургии</p></bio><email>elschad.askerov@yandex.ru</email><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Tver State Medical University</institution></aff><aff><institution xml:lang="ru">Тверской государственный медицинский университет</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2024-06-15" publication-format="electronic"><day>15</day><month>06</month><year>2024</year></pub-date><volume>17</volume><issue>1</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>41</fpage><lpage>50</lpage><history><date date-type="received" iso-8601-date="2023-04-07"><day>07</day><month>04</month><year>2023</year></date><date date-type="accepted" iso-8601-date="2024-03-17"><day>17</day><month>03</month><year>2024</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2024, Morozov A.M., Sergeev A.N., Askerov E.M.</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2024, Морозов А.М., Сергеев А.Н., Аскеров Э.М.</copyright-statement><copyright-year>2024</copyright-year><copyright-holder xml:lang="en">Morozov A.M., Sergeev A.N., Askerov E.M.</copyright-holder><copyright-holder xml:lang="ru">Морозов А.М., Сергеев А.Н., Аскеров Э.М.</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">http://creativecommons.org/licenses/by-nc-nd/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://vestnik-surgery.com/journal/article/view/1716">https://vestnik-surgery.com/journal/article/view/1716</self-uri><abstract xml:lang="en"><p>As a research task, the authors attempted to assess factors affecting the results of the experiment involving laboratory animals in the perioperative period and the modes of their action. The perioperative period has a significant impact on the state of organ systems, in particular, and on the vital activity of the organism, as a whole. This paper describes the key points having an impact on successful surgical interventions. Particular attention is paid to the main groups of factors that affect the severity of perioperative complications - hypoxia, hypothermia, the use of pharmacological drugs, the human factor, the preparation of the animal for surgery, as well as the choice of anesthesia and the method of its administration. One of the reasons leading to the death of the operated animal is the failure of the sutures in the area of surgical intervention, which is often caused by the action of endogenous microorganisms in the area of the operation. The scientific novelty of the study lies in a systematic approach to the examined material accumulated as a result of numerous studies. Based on the results obtained, a list of groups of factors, their influence on the body, and ways to eliminate their role in the occurrence of perioperative complications was determined.</p></abstract><trans-abstract xml:lang="ru"><p>В качестве исследовательской задачи авторами была определена попытка оценить - как и какие факторы влияют на результаты эксперимента в периоперационном периоде при использовании в качестве объекта исследования лабораторных животных. Периоперационный период оказывает значительное влияние на состояние систем и органов, в частности, и на жизнедеятельность организма в целом. В данной статье описаны ключевые моменты, от которых зависит успех хирургической операции. Особое внимание уделено основным группам факторов, которые оказывают влияние на выраженность частоту развития периоперационных осложнений: гипоксии и гипотермии, использованию фармакологических препаратов, человеческому фактору, качеству подготовки животного к операции, а также выбору оптимального варианта наркоза и способу его введения. Наиболее частыми причинами смерти лабораторных животных являются ошибки проведения анестезиологического пособия, несостоятельность швов, а также развитие других гнойных осложнений области оперативного вмешательства. Научная новизна работы заключается в системном подходе к изучению накопленного в результате многих исследований материала. На основе изучения данного вопроса был определен ряд факторов, их влияние на организм, а также способы нивелирования роли этих фактов на возникновение периоперационных осложнений.</p></trans-abstract><kwd-group xml:lang="en"><kwd>laboratory animals</kwd><kwd>anesthesia</kwd><kwd>perioperative period</kwd><kwd>operation</kwd><kwd>hypothermia</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>лабораторные животные</kwd><kwd>наркоз</kwd><kwd>периоперационный период</kwd><kwd>операция</kwd><kwd>гипотермия</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><citation-alternatives><mixed-citation xml:lang="en">Lazarenko VA, Tkachenko PV, Lipatov VA, Naimzada MD. Scientific Laboratory management: best practices and challenges of the time. Akkreditaciya v obrazovanii. 2019; 4: 26-28. (in Russ.)</mixed-citation><mixed-citation xml:lang="ru">Лазаренко В.А., Ткаченко П.В., Липатов В.А., Наимзада М.Д. 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