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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="research-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Journal of Experimental and Clinical Surgery</journal-id><journal-title-group><journal-title xml:lang="en">Journal of Experimental and Clinical Surgery</journal-title><trans-title-group xml:lang="ru"><trans-title>Вестник экспериментальной и клинической хирургии</trans-title></trans-title-group></journal-title-group><issn publication-format="print">2070-478X</issn><issn publication-format="electronic">2409-143X</issn><publisher><publisher-name xml:lang="en">Voronezh State Medical University named after N.N. Burdenko</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">1791</article-id><article-id pub-id-type="doi">10.18499/2070-478X-2024-17-4-198-203</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Cases from practice</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Случаи из практики (архивный)</subject></subj-group><subj-group subj-group-type="article-type"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">The Effectiveness of Systemic Thrombolysis in the Treatment of Massive Pulmonary Embolism</article-title><trans-title-group xml:lang="ru"><trans-title>Эффективность системного тромболизиса в лечении массивной эмболии легочной артерии</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-2197-8756</contrib-id><name-alternatives><name xml:lang="en"><surname>Sukovatykh</surname><given-names>Boris S.</given-names></name><name xml:lang="ru"><surname>Суковатых</surname><given-names>Борис Семенович</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>M.D., Professor, Head of the Department of General Surgery</p></bio><bio xml:lang="ru"><p>доктор медицинских наук, профессор, заведующий кафедрой общей хирургии</p></bio><email>SukovatykhBS@kursksmu.net</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Gordov</surname><given-names>Maxim Y.</given-names></name><name xml:lang="ru"><surname>Гордов</surname><given-names>Максим Юрьевич</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Head of the Vascular Surgery Department</p></bio><bio xml:lang="ru"><p>заведующий отделением сосудистой хирургии</p></bio><email>maks_gordov@mail.ru</email><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Larina</surname><given-names>Inna V.</given-names></name><name xml:lang="ru"><surname>Ларина</surname><given-names>Инна Валерьевна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>surgeon of the Vascular Surgery Department</p></bio><bio xml:lang="ru"><p>врач-хирург отделения сосудистой хирургии</p></bio><email>maks_gordov@mail.ru</email><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Valuyskaya</surname><given-names>Nelly M.</given-names></name><name xml:lang="ru"><surname>Валуйская</surname><given-names>Нелли Михайловна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Ph.D., Associate Professor of the Department of General Surgery</p></bio><bio xml:lang="ru"><p>кандидат медицинских наук, доцент кафедры общей хирургии</p></bio><email>valuiskayanm@kursksmu.net</email><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Kursk State Medical University</institution></aff><aff><institution xml:lang="ru">Курский государственный медицинский университет</institution></aff></aff-alternatives><aff-alternatives id="aff2"><aff><institution xml:lang="en">Kursk City Clinical Hospital of Emergency Medical Care</institution></aff><aff><institution xml:lang="ru">Курская городская клиническая больница скорой медицинской помощи</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2024-12-11" publication-format="electronic"><day>11</day><month>12</month><year>2024</year></pub-date><volume>17</volume><issue>4</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>198</fpage><lpage>203</lpage><history><date date-type="received" iso-8601-date="2024-02-05"><day>05</day><month>02</month><year>2024</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2024, Voronezh N.N. Burdenko State Medical University</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2024, ФГБОУ ВО ВГМУ им. Н.Н. Бурденко Минздрава России</copyright-statement><copyright-year>2024</copyright-year><copyright-holder xml:lang="en">Voronezh N.N. Burdenko State Medical University</copyright-holder><copyright-holder xml:lang="ru">ФГБОУ ВО ВГМУ им. Н.Н. Бурденко Минздрава России</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/" start_date="2027-12-11"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://vestnik-surgery.com/journal/about/editorialPolicies</ali:license_ref></license></permissions><self-uri xlink:href="https://vestnik-surgery.com/journal/article/view/1791">https://vestnik-surgery.com/journal/article/view/1791</self-uri><abstract xml:lang="en"><p>The article presents a case of timely diagnosis and successful treatment of massive pulmonary embolism in a young man suffering from obesity, hypertension and osteochondrosis of the lumbar spine. The disease was manifested with symptoms of acute respiratory failure, hemodynamics was stable. Laboratory tests revealed an increase in the level of D-dimer and hypercoagulation. Electrocardiographic examination revealed signs of overloading of the right ventricle, and echocardiography revealed pulmonary hypertension of the 2nd degree. Ultrasound examination of the venous system of the lower extremities detected that the cause of the embolism was the migration of a blood clot from a thrombosed femoral vein. The diagnosis was confirmed during computed tomography of the lungs with intravenous contrast. Thrombolytic therapy was performed with alteplase in standard dosages. The patient underwent anticoagulant therapy for 3 months.</p></abstract><trans-abstract xml:lang="ru"><p>В статье представлен случай своевременной диагностики и успешного лечения массивной тромбоэмболии легочной артерии у мужчины молодого возраста, страдающего ожирением, гипертонической болезнью и остеохондрозом поясничного отдела позвоночника. Заболевание проявлялось симптомами острой дыхательной недостаточности, гемодинамика была стабильной. Лабораторные исследования выявили повышение уровня Д-димера и гиперкоагуляцию. При электрокардиографическом исследовании установлены признаки перезрузки правого желудочка, а при эхокардиографии – лёгочная гипертензия 2-й степени. При ультразвуковом исследовании венозной системы нижних конечностей установлено, что причиной эмболии являлась миграция тромба из тромбированной бедренной вены. Диагноз был подтвержден во время компьютерной томографии лёгких с внутривенным контрастированием. Тромболитическая терапия проводилась алтеплазой в стандартных дозировках. В течении 3 месяцев пациенту проводилась антикоагулянтная терапия. Через 3 месяца трудоспособность была восстановлена.</p></trans-abstract><kwd-group xml:lang="en"><kwd>thrombosis</kwd><kwd>deep veins of the lower extremities</kwd><kwd>thromboembolism</kwd><kwd>pulmonary artery</kwd><kwd>alteplase</kwd><kwd>heparin</kwd><kwd>apixaban</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>тромбоз</kwd><kwd>глубокие вены нижних конечностей</kwd><kwd>тромбоэмболия</kwd><kwd>легочная артерия</kwd><kwd>алтеплаза</kwd><kwd>гепарин</kwd><kwd>апиксабан</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><citation-alternatives><mixed-citation xml:lang="en">Kokov LS. Tromboemboliya legochnoi arterii. Klassicheskaya diagnostika, noveishie metody profilaktiki i lecheniya: rukovodstvo dlya vrachei. M.: RAN. 2022; 378. (in Russ.)</mixed-citation><mixed-citation xml:lang="ru">Коков Л.С. Тромбоэмболия лёгочной артерии. Классическая диагностика, новейшие методы профилактики и лечения: руководство для врачей. 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