<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE root>
<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="research-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Journal of Experimental and Clinical Surgery</journal-id><journal-title-group><journal-title xml:lang="en">Journal of Experimental and Clinical Surgery</journal-title><trans-title-group xml:lang="ru"><trans-title>Вестник экспериментальной и клинической хирургии</trans-title></trans-title-group></journal-title-group><issn publication-format="print">2070-478X</issn><issn publication-format="electronic">2409-143X</issn><publisher><publisher-name xml:lang="en">Voronezh State Medical University named after N.N. Burdenko</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">1809</article-id><article-id pub-id-type="doi">10.18499/2070-478X-2024-17-3-84-92</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Original articles</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Оригинальные статьи</subject></subj-group><subj-group subj-group-type="article-type"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Specific Complications after Pancreatoduodenal Resection Depending on the Pancreatic Transection Plane and the Dorsal Pancreatic Artery Origin</article-title><trans-title-group xml:lang="ru"><trans-title>Специфические осложнения после панкреатодуоденальной резекции в зависимости от уровня пересечения поджелудочной железы и места отхождения дорсальной панкреатической артерии</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-7283-7465</contrib-id><contrib-id contrib-id-type="spin">2025-4436</contrib-id><name-alternatives><name xml:lang="en"><surname>Dvuhzhilov</surname><given-names>Mihail V.</given-names></name><name xml:lang="ru"><surname>Двухжилов</surname><given-names>Михаил Вячеславович</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>main specialist of Methodic accreditation simulation Centre</p></bio><bio xml:lang="ru"><p>главный специалист Методического аккредитационно-симуляционного центра</p></bio><email>dr.dvukhzhilov@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-9074-5676</contrib-id><contrib-id contrib-id-type="spin">6808-9492</contrib-id><name-alternatives><name xml:lang="en"><surname>Markov</surname><given-names>Pavel V.</given-names></name><name xml:lang="ru"><surname>Марков</surname><given-names>Павел Викторович</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>M.D., Head of Abdominal Surgery Department</p></bio><bio xml:lang="ru"><p>доктор медицинских наук, заведующий отделением абдоминальной хирургии</p></bio><email>markov@ixv.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-6452-4458</contrib-id><contrib-id contrib-id-type="spin">4284-4275</contrib-id><name-alternatives><name xml:lang="en"><surname>Gorin</surname><given-names>David S.</given-names></name><name xml:lang="ru"><surname>Горин</surname><given-names>Давид Семенович</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>M.D., Senior Research of Abdominal Surgery Department</p></bio><bio xml:lang="ru"><p>доктор медицинских наук, старший научный сотрудник отделения абдоминальной хирургии</p></bio><email>davidc83@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-7683-3672</contrib-id><contrib-id contrib-id-type="spin">6623-6910</contrib-id><name-alternatives><name xml:lang="en"><surname>Shirokov</surname><given-names>Vadim Sergeevich</given-names></name><name xml:lang="ru"><surname>Широков</surname><given-names>Вадим Сергеевич</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>radiologist of Roentgen and magnet resonance diagnosis Department</p></bio><bio xml:lang="ru"><p>врач-рентгенолог отделения рентгенологии и магнитно-резонансных исследований</p></bio><email>vadimshirokov@yandex.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-4567-8312</contrib-id><contrib-id contrib-id-type="spin">3496-8889</contrib-id><name-alternatives><name xml:lang="en"><surname>Kriger</surname><given-names>Andrej G.</given-names></name><name xml:lang="ru"><surname>Кригер</surname><given-names>Андрей Германович</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>M.D., Professor, main researcher of labratory of surgical technology in oncology</p></bio><bio xml:lang="ru"><p>доктор медицинских наук, профессор, главный научный сотрудник лаборатории хирургических технологий в онкологии</p></bio><email>krigerandreyg@mail.ru</email><xref ref-type="aff" rid="aff2"/><xref ref-type="aff" rid="aff3"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-1555-1596</contrib-id><contrib-id contrib-id-type="spin">4996-7802</contrib-id><name-alternatives><name xml:lang="en"><surname>Struchkov</surname><given-names>Vladimir Yu.</given-names></name><name xml:lang="ru"><surname>Стручков</surname><given-names>Владимир Юрьевич</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Ph.D., Surgeon of Abdominal Surgery Department</p></bio><bio xml:lang="ru"><p>кандидат медицинских наук, врач-хирург отделения абдоминальной хирургии</p></bio><email>doc.struchkov@gmail.com</email><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">A.V. Vishnevsky National Medical Research Center of Surgery</institution></aff><aff><institution xml:lang="ru">Национальный медицинский исследовательский центр хирургии имени А.В. Вишневского</institution></aff></aff-alternatives><aff-alternatives id="aff2"><aff><institution xml:lang="en">Russian Scientific Center of Rentgenoradiology</institution></aff><aff><institution xml:lang="ru">Российский научный центр рентгенорадиологии</institution></aff></aff-alternatives><aff-alternatives id="aff3"><aff><institution xml:lang="en">Russian Medical Academy of Continuous Professional Education</institution></aff><aff><institution xml:lang="ru">Российская медицинская академия непрерывного профессионального образования</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2024-08-18" publication-format="electronic"><day>18</day><month>08</month><year>2024</year></pub-date><volume>17</volume><issue>3</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>84</fpage><lpage>92</lpage><history><date date-type="received" iso-8601-date="2024-04-11"><day>11</day><month>04</month><year>2024</year></date><date date-type="accepted" iso-8601-date="2024-07-27"><day>27</day><month>07</month><year>2024</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2024, Voronezh N.N. Burdenko State Medical University</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2024, ФГБОУ ВО ВГМУ им. Н.Н. Бурденко Минздрава России</copyright-statement><copyright-year>2024</copyright-year><copyright-holder xml:lang="en">Voronezh N.N. Burdenko State Medical University</copyright-holder><copyright-holder xml:lang="ru">ФГБОУ ВО ВГМУ им. Н.Н. Бурденко Минздрава России</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://vestnik-surgery.com/journal/about/editorialPolicies</ali:license_ref></license></permissions><self-uri xlink:href="https://vestnik-surgery.com/journal/article/view/1809">https://vestnik-surgery.com/journal/article/view/1809</self-uri><abstract xml:lang="en"><p><bold>Introduction</bold><bold>. </bold>Pancreaticoduodenectomy (the Whipple procedure) is one of the most complex surgical interventions in abdominal surgery and is associated with a high risk of severe postoperative complications. Studying all aspects of the operation can reduce the incidence of adverse outcomes. One of the ways to reduce the incidence of postoperative complications after pancreaticoduodenectomy is to shift the pancreatic transection line to the left in order to remove the poorly blood-supplied zone between the cephalocervical and corporocaudal segments.</p> <p><bold>The</bold><bold> </bold><bold>aim</bold><bold> </bold><bold>of</bold><bold> </bold><bold>the</bold><bold> </bold><bold>study</bold><bold> </bold>was to evaluate the effect of different pancreatic transection planes on the incidence of pancreatic fistula in various anatomical origins of the dorsal pancreatic artery.</p> <p><bold>Material</bold><bold> </bold><bold>and</bold><bold> </bold><bold>Methods</bold><bold>. </bold>The study included 103 patients with the determined origin of the dorsal pancreatic artery. All patients were divided into two groups: with a standard origin of the dorsal pancreatic artery (69 patients) and with a variant origin of the dorsal pancreatic artery (34 patients). In each group, two subgroups were identified depending on the transection plane of the pancreas (at the midpoint of the portal vein and 10-15 mm to the left of its left edge). The short-tern treatment outcomes in subgroups were compared based on the arterial anatomy and transection plane.</p> <p><bold>Results</bold><bold>. </bold>In cases of a standard origin of the dorsal pancreatic artery, relocation of the transection plane to the left led to a statistically significant reduction in the frequency of specific complications (p=0.04), clinically significant pancreatic fistula (p=0.037), and gastrostasis type B (ISGPS) (p=0.038). In cases of a variant origin of the dorsal pancreatic artery, no statistically significant difference in subgroups with different transection planes was found.</p> <p><bold>Conclusion</bold><bold>. </bold>In case of a standard origin of the dorsal pancreatic artery, it is advisable to shift the transection line to the left. The algorithm for transecting the pancreas in other variants of the dorsal pancreatic artery origin requires further study.</p></abstract><trans-abstract xml:lang="ru"><p><bold>Введение. </bold>Панкреатодуоденальная резекция (ПДР) является одним из сложнейших хирургических вмешательств в абдоминальной хирургии и сопряжена с высоким риском развития тяжелых послеоперационных осложнений. Изучение всех аспектов выполнения операции может снизить частоту нежелательных исходов. Одним из способов уменьшения частоты послеоперационных осложнений после панкреатодуоденальной резекции является смещение линии пересечения поджелудочной железы влево с целью удаления плохо кровоснабжаемой зоны между цефалоцервикальным и корпорокаудальным сегментами.</p> <p><bold>Цель исследования. </bold>Оценить эффект разного уровня пересечения поджелудочной железы (ПЖ) при выполнении ПДР на частоту развития панкреатического свища (ПС) при различных анатомических вариантах отхождения дорсальной панкреатической артерии.</p> <p><bold>Материал и методы. </bold>В исследование вошло 103 пациента, у которых было определено место отхождения дорсальной панкреатической артерии. Выделены две группы пациентов: со стандартным отхождением дорсальной панкреатической артерии (69 пациентов) и с вариантным (34 пациента). В каждой группе выделены по две подгруппы в зависимости от места пересечения поджелудочной железы (по середине воротной вены и на 10-15 мм левее её левого края). Сравнивались ближайшие результаты лечения в подгруппах в зависимости от ангиоархитектоники.</p> <p><bold>Результаты. </bold>В случаях стандартного места отхождения дорсальной панкреатической артерии смещение линии пересечения влево привело к статистически значимому уменьшению общей частоты развития специфических осложнений (р=0,04), частоты формирования клинически значимого панкреатического свища (р=0,037) и гастростаза типа В по ISGPS (p=0,038). При вариантном отхождении дорсальной панкреатической артерии статистически значимой разницы выявлено не было.</p> <p><bold>Заключение. </bold>При стандартном отхождении дорсальной панкреатической артерии целесообразно смещать линию пересечения поджелудочной железы влево. Эффективность смещения линии пересечения поджелудочной железы при иных вариантах<italic> </italic>отхождения дорсальной панкреатической артерии требует дальнейшего изучения, ангиоархитектоника поджелудочной железы.</p></trans-abstract><kwd-group xml:lang="en"><kwd>pancreaticoduodenal resection</kwd><kwd>pancreas</kwd><kwd>dorsal pancreatic artery</kwd><kwd>pancreatic fistula</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>панкреатодуоденальная резекция</kwd><kwd>поджелудочная железа</kwd><kwd>дорсальная панкреатическая артерия</kwd><kwd>панкреатический свищ</kwd><kwd>ангиоархитектоника поджелудочной железы</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Jin KM, Liu W, Wang K, Bao Q, Wang HW, Xing BC. The individualized selection of Pancreaticoenteric anastomosis in Pancreaticoduodenectomy. BMC Surg. 2020;20(1):140. doi:10.1186/s12893-020-00791-y</mixed-citation></ref><ref id="B2"><label>2.</label><mixed-citation>Hirono S, Shimokawa T, Nagakawa Y, et al. Risk factors for pancreatic fistula grade C after pancreatoduodenectomy: A large prospective, multicenter Japan-Taiwan collaboration study. J Hepatobiliary Pancreat Sci. 2020;27(9):622-631. doi:10.1002/jhbp.799</mixed-citation></ref><ref id="B3"><label>3.</label><mixed-citation>Aoki S, Miyata H, Konno H. Risk factors of serious postoperative complications after pancreaticoduodenectomy and risk calculators for predicting postoperative complications: a nationwide study of 17,564 patients in Japan. J Hepatobiliary Pancreat Sci. 2017;24(5):243-251. doi:10.1002/jhbp.438</mixed-citation></ref><ref id="B4"><label>4.</label><mixed-citation>Akgul O, Merath K, Mehta R. Postoperative Pancreatic Fistula Following Pancreaticoduodenectomy—Stratification of Patient Risk. J Gastrointest Surg. 2019;23(9):1817-1824. doi:10.1007/s11605-018-4045-x</mixed-citation></ref><ref id="B5"><label>5.</label><mixed-citation>Probst P, Hüttner FJ, Meydan Ö. Evidence Map of Pancreatic Surgery–A living systematic review with meta-analyses by the International Study Group of Pancreatic Surgery (ISGPS). Surgery. 2021;170(5):1517-1524. doi:10.1016/j.surg.2021.04.023</mixed-citation></ref><ref id="B6"><label>6.</label><mixed-citation>Singh K, Kaman L, Tandup C, Raypattanaik N, Dahiya D, Behera A. Internal stenting across the pancreaticojejunostomy and main pancreatic duct after pancreaticoduodenectomy. Pol Przegl Chir. 2021;93(3):40-47. doi:10.5604/01.3001.0014.7225</mixed-citation></ref><ref id="B7"><label>7.</label><mixed-citation>Solodky VA, Kriger AG, Gorin DS. Pancreaticoduodenectomy — results and prospects (two-center study). Khir Z im NI Pirogova. 2023;(5):13. doi:10.17116/hirurgia202305113</mixed-citation></ref><ref id="B8"><label>8.</label><mixed-citation>Bassi C, Marchegiani G, Dervenis C. The 2016 update of the International Study Group (ISGPS) definition and grading of postoperative pancreatic fistula: 11 Years After. Surgery. 2017;161(3):584-591. doi:10.1016/j.surg.2016.11.014</mixed-citation></ref><ref id="B9"><label>9.</label><mixed-citation>Strasberg SM, Drebin JA, Mokadam NA. Prospective Trial of a Blood Supply-Based Technique of Pancreaticojejunostomy: Effect on Anastomotic Failure in the Whipple Procedure. Journal of the American College of Surgeons. 2002;194(6):746-758. doi:10.1016/S1072-7515(02)01202-4</mixed-citation></ref><ref id="B10"><label>10.</label><mixed-citation>Jwa EK, Hwang S. Extended pancreatic transection for secure pancreatic reconstruction during pancreaticoduodenectomy. Ann Hepatobiliary Pancreat Surg. 2017;21(3):138. doi:10.14701/ahbps.2017.21.3.138</mixed-citation></ref><ref id="B11"><label>11.</label><mixed-citation>Bardol T, Delicque J, Hermida M. Neck transection level and postoperative pancreatic fistula after pancreaticoduodenectomy: A retrospective cohort study of 195 patients. International Journal of Surgery. 2020;82:43-50. doi:10.1016/j.ijsu.2020.08.001</mixed-citation></ref><ref id="B12"><label>12.</label><mixed-citation>Kriger AG, Pronin NA, Dvukhzhilov MV, Gorin DS, Pavlov AV, Karmazonovsky GG. Surgical glance at pancreatic arterial anatomy. Ann hir gepatol. 2021;26(3):112-122. doi:10.16931/1995-5464.2021-3-112-122</mixed-citation></ref><ref id="B13"><label>13.</label><mixed-citation>Busnardo AC, DiDio LJA, Thomford NR. Anatomicosurgical segments of the human pancreas. Surg Radiol Anat. 1988;10(1):77-82. doi:10.1007/BF02094076</mixed-citation></ref><ref id="B14"><label>14.</label><mixed-citation>Skandalakis LJ, Rowe JS, Gray SW, Skandalakis JE. Surgical Embryology and Anatomy of the Pancreas. Surgical Clinics of North America. 1993;73(4):661-697. doi:10.1016/S0039-6109(16)46080-9</mixed-citation></ref><ref id="B15"><label>15.</label><mixed-citation>Laaninen M, Bläuer M, Vasama K. The risk for immediate postoperative complications after pancreaticoduodenectomy is increased by high frequency of acinar cells and decreased by prevalent fibrosis of the cut edge of pancreas. Pancreas. 2012;41(6):957-961. doi:10.1097/MPA.0b013e3182480b81</mixed-citation></ref><ref id="B16"><label>16.</label><mixed-citation>Andreasi V, Partelli S, Rancoita PMV. Clinical and economic validation of grade B postoperative pancreatic fistula subclassification. Surgery. 2022;171(4):846-853. doi:10.1016/j.surg.2021.09.006</mixed-citation></ref><ref id="B17"><label>17.</label><mixed-citation>Bannone E, Andrianello S, Marchegiani G. Postoperative hyperamylasemia (POH) and acute pancreatitis after pancreatoduodenectomy (POAP): State of the art and systematic review. Surgery. 2021;169(2):377-387. doi:10.1016/j.surg.2020.04.062</mixed-citation></ref><ref id="B18"><label>18.</label><mixed-citation>Connor S. Defining post-operative pancreatitis as a new pancreatic specific complication following pancreatic resection. HPB. 2016;18(8):642-651. doi:10.1016/j.hpb.2016.05.006</mixed-citation></ref><ref id="B19"><label>19.</label><mixed-citation>Chandrabalan VV, McMillan DC, Carter R. Pre-operative cardiopulmonary exercise testing predicts adverse post-operative events and non-progression to adjuvant therapy after major pancreatic surgery. HPB. 2013;15(11):899-907. doi:10.1111/hpb.12060</mixed-citation></ref><ref id="B20"><label>20.</label><mixed-citation>Cuthbertson CM, Christophi C. Disturbances of the microcirculation in acute pancreatitis. British Journal of Surgery. 2006;93(5):518-530. doi:10.1002/bjs.5316</mixed-citation></ref><ref id="B21"><label>21.</label><mixed-citation>Bannone E, Andrianello S, Marchegiani G, et al. Postoperative Acute Pancreatitis Following Pancreaticoduodenectomy: A Determinant of Fistula Potentially Driven by the Intraoperative Fluid Management. Annals of Surgery. 2018;268(5):815-822. doi:10.1097/SLA.0000000000002900</mixed-citation></ref><ref id="B22"><label>22.</label><mixed-citation>Sugimoto M, Takahashi S, Kobayashi T. Pancreatic perfusion data and post-pancreaticoduodenectomy outcomes. Journal of Surgical Research. 2015;194(2):441-449. doi:10.1016/j.jss.2014.11.046</mixed-citation></ref><ref id="B23"><label>23.</label><mixed-citation>Szuák A, Korom C, Németh K, Nemeskéri Á, Harsányi L. Can the transection plane be optimized in pancreatic resections? Physiol Int. 2023; 110(1):46-51. doi:10.1556/2060.2022.00122</mixed-citation></ref><ref id="B24"><label>24.</label><citation-alternatives><mixed-citation xml:lang="en">SiguA BV, Zemlyanoy VP, Zakharov EA, Tsikoridze MY, Napalkov AN. Unconventional Technique of Terminolateral Pancreatojejunostomy Formation. Journal of Experimental and Clinical Surgery. 2021;14(1):25-32.</mixed-citation><mixed-citation xml:lang="ru">Сигуа Б.В., Земляной В.П., Захаров Е.А., Цикоридзе М.Ю., Напалков А.Н. Оригинальный способ формирования терминолатерального панкреатоеюноанастомоза. Вестник экспериментальной и клинической хирургии. 2021;14(1):25-32.</mixed-citation></citation-alternatives></ref></ref-list></back></article>
