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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="other" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Journal of Experimental and Clinical Surgery</journal-id><journal-title-group><journal-title xml:lang="en">Journal of Experimental and Clinical Surgery</journal-title><trans-title-group xml:lang="ru"><trans-title>Вестник экспериментальной и клинической хирургии</trans-title></trans-title-group></journal-title-group><issn publication-format="print">2070-478X</issn><issn publication-format="electronic">2409-143X</issn><publisher><publisher-name xml:lang="en">Voronezh State Medical University named after N.N. Burdenko</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">198</article-id><article-id pub-id-type="doi">10.18499/2070-478X-2015-8-2-176-185</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Original articles</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Оригинальные статьи</subject></subj-group><subj-group subj-group-type="article-type"><subject>Unknown</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Postmortem Tissue Analysis of Opisthorchiasis Papillitis</article-title><trans-title-group xml:lang="ru"><trans-title>Патоморфология описторхозного папиллита</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name><surname>Онищенко</surname><given-names>С.В.</given-names></name><bio xml:lang="en"><p>PhD, assoc. prof. of chair of hospital surgery, head of the Oncology Department budgetary institution "Surgut Regional clinical hospital"</p></bio><bio xml:lang="ru"><p>к.м.н., доц., зав. онкологическим отделением БУ ХМАО-Югры «Сургутская окружная клиническая больница»</p></bio><email>author@vestnik-surgery.com</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name><surname>Дарвин</surname><given-names>В.В.</given-names></name><bio xml:lang="en"><p>MD, Prof., supernumerary chief specialist in Surgery budgetary institution "Surgut Regional clinical hospital"</p></bio><bio xml:lang="ru"><p>д.м.н., проф., главный внештатный специалист по хирургии БУ ХМАО-Югры «Сургутская окружная клиническая больница»</p></bio><email>author@vestnik-surgery.com</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name><surname>Лысак</surname><given-names>М.М.</given-names></name><bio xml:lang="en"><p>PhD, doctor Surgery Department of budgetary institution "Surgut Regional clinical hospital"</p></bio><bio xml:lang="ru"><p>к.м.н., врач хирургического отделения БУ ХМАО-Югры «Сургутская окружная клиническая больница»</p></bio><email>author@vestnik-surgery.com</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name><surname>Шаталов</surname><given-names>В.Г.</given-names></name><bio xml:lang="en"><p>doctor Pathology Department of budgetary institution "Surgut Regional clinical hospital"</p></bio><bio xml:lang="ru"><p>врач патологоанатомического отделения БУ ХМАО-Югры «Сургутская окружная клиническая больница»</p></bio><email>author@vestnik-surgery.com</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name><surname>Новосёлов</surname><given-names>А.И.</given-names></name><bio xml:lang="en"><p>doctor Pathology Department of budgetary institution "Surgut Regional clinical hospital"</p></bio><bio xml:lang="ru"><p>врач патологоанатомического отделения БУ ХМАО-Югры «Сургутская окружная клиническая больница»</p></bio><email>author@vestnik-surgery.com</email><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Surgut Regional Clinical Hospital, 14 Energetikov Str., Surgut, 624000, Russian Federation</institution></aff><aff><institution xml:lang="ru">Сургутская окружная клиническая больница, ул. Энергетиков, д. 14, Сургут, 626400, Российская Федерация</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2015-06-24" publication-format="electronic"><day>24</day><month>06</month><year>2015</year></pub-date><volume>8</volume><issue>2</issue><issue-title xml:lang="ru"/><fpage>176</fpage><lpage>185</lpage><history><date date-type="received" iso-8601-date="2016-04-27"><day>27</day><month>04</month><year>2016</year></date><date date-type="accepted" iso-8601-date="2016-04-27"><day>27</day><month>04</month><year>2016</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2015, Voronezh N.N. Burdenko State Medical University</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2015, ФГБОУ ВО ВГМУ им. Н.Н. Бурденко Минздрава России</copyright-statement><copyright-year>2015</copyright-year><copyright-holder xml:lang="en">Voronezh N.N. Burdenko State Medical University</copyright-holder><copyright-holder xml:lang="ru">ФГБОУ ВО ВГМУ им. Н.Н. Бурденко Минздрава России</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://vestnik-surgery.com/journal/about/editorialPolicies</ali:license_ref></license></permissions><self-uri xlink:href="https://vestnik-surgery.com/journal/article/view/198">https://vestnik-surgery.com/journal/article/view/198</self-uri><abstract xml:lang="en"><p><bold>The purpose of the study</bold> The research is aimed at examining histologic and morphometric aspects of the major duodenal papilla which has opisthorchiasis invasion.<bold>Materials and methods</bold> The research uses cadaveric material taken in the department of morbid anatomy of Surgut regional clinical hospital. All the cases which were included in the study (98 dead patients) had the direct evidence of infection with opisthorchiasis according to post-mortem examination together with information about the length of opisthorchiasis invasion during the life of the patients. The control group included 30 dead patients without the pathology of hepatobiliary tract. The study showed that the opisthorchiasis invasion brings about successive changes in papilla tissues which can be divided into three stages according to morphological criteria - the adenomatous stage, the adenofibrous stage and the sclerotic stage (the names reflect the nature of changes). The analysis of the material was carried out using statistical approach.<bold>Results and their discussion</bold> Morphological research with sufficient evidence demonstrated specific changes which take place in the tissues of the major duodenal papilla at different stages of papillitis. It also determined that the luminal diameter of papilla is the indicator of these changes.<bold>Conclusion</bold> The general tendency of changes in the major duodenal papilla brought about by opesthorchiasis can be described as progressive degradation of morphological structures that constitute the tissue of the major duodenal papilla, which results in functional failure of the given anatomical structure.</p></abstract><trans-abstract xml:lang="ru"><p><bold>Целью исследования</bold> явилось изучение гистологических и морфометрических аспектов большого сосочка двенадцатиперстной кишки (ДПК) на фоне описторхозной инвазии.<bold>Материалы и методы</bold> Исследование проводилось на трупном материале патологоанатомического отделения Сургутской окружной клинической больницы. Наличие достоверных признаков описторхоза по данным вскрытия, в сочетании с информацией о длительности инвазии в прижизненной документации, являлось критерием включения данного случая в исследование (98 умерших). Контрольную группу составили 30 умерших без патологии гепатобилиарной зоны. В ответ на описторхозную инвазию в тканях большого сосочка ДПК последовательно происходят изменения, которые по морфологическим признакам можно разделить на три стадии – аденоматозную, аденофибропластическую и склеротическую (названия стадий отображают суть происходящих изменений). При анализе материала применялись статистические методы обработки информации.<bold>Результаты и их обсуждения</bold> Морфологические исследования на доказательном уровне позволили определить специфические изменения, происходящие в тканях большого сосочка ДПК соответственно стадиям папиллита, а также считать показатели диаметра просвета сосочка индикатором происходящих изменений.<bold>Заключение</bold> Общую тенденцию происходящих изменений в тканях большого сосочка ДПК при описторхозном папиллите можно характеризовать как прогрессирующую деградацию морфологических структур, составляющих стенку большого сосочка ДПК, приводящую в итоге к функциональной несостоятельности данного анатомического образования</p></trans-abstract><kwd-group xml:lang="en"><kwd>opisthorchosis</kwd><kwd>papillitis</kwd><kwd>papillary stenosis</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>описторхоз</kwd><kwd>папиллит</kwd><kwd>стеноз большого сосочка ДПК</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>1.Al'perovich B.I., Revskoi A.Iu., Brazhnikova N.A. 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