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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="other" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Journal of Experimental and Clinical Surgery</journal-id><journal-title-group><journal-title xml:lang="en">Journal of Experimental and Clinical Surgery</journal-title><trans-title-group xml:lang="ru"><trans-title>Вестник экспериментальной и клинической хирургии</trans-title></trans-title-group></journal-title-group><issn publication-format="print">2070-478X</issn><issn publication-format="electronic">2409-143X</issn><publisher><publisher-name xml:lang="en">Voronezh State Medical University named after N.N. Burdenko</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">202</article-id><article-id pub-id-type="doi">10.18499/2070-478X-2013-6-2-175-187</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Original articles</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Оригинальные статьи</subject></subj-group><subj-group subj-group-type="article-type"><subject>Unknown</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Experimental Study of Local Cryohemostasis in Cases of Liver and Spleen Damage</article-title><trans-title-group xml:lang="ru"><trans-title>Экспериментальное исследование локального криогемостаза при повреждениях печени и селезенки</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name><surname>Александров</surname><given-names>В.В</given-names></name><bio xml:lang="en"><p>post-graduate student of the chair of hospital surgery of the Volgograd State Medical University.</p></bio><bio xml:lang="ru"><p>аспирант кафедры госпитальной хирургии Волгоградского государственного медицинского университета</p></bio><email>author@vestnik-surgery.com</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name><surname>Маскин</surname><given-names>С.С</given-names></name><bio xml:lang="en"><p>head of the chair of hospital surgery of the Volgograd State Medical University, doctor of medicine</p></bio><bio xml:lang="ru"><p>д.м.н., проф., зав. каф. госпитальной хирургии Волгоградского госу- дарственного медицинского университета</p></bio><email>maskins@bk.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name><surname>Ермолаева</surname><given-names>Н.К</given-names></name><bio xml:lang="en"><p>assistant of the chair of hospital surgery of the Volgograd State Medical University, candidate of medical Sciences.</p></bio><bio xml:lang="ru"><p>к.м.н., асс. кафедры госпитальной хирургии Волгоградского государственного медицинского университета</p></bio><email>author@vestnik-surgery.com</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name><surname>Иголкина</surname><given-names>Л.А</given-names></name><bio xml:lang="en"><p>assistant of the chair of hospital surgery of the Volgograd State Medical University, candidate of medical Sciences</p></bio><bio xml:lang="ru"><p>к.м.н., асс. ка- федры госпитальной хирургии Волгоградского го- сударственного медицинского университета</p></bio><email>author@vestnik-surgery.com</email><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Volgograd State Medical University, Volgograd, Russian Federation</institution></aff><aff><institution xml:lang="ru">Волгоградский государственный медицинский университет, Волгоград, Российская Федерация</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2013-06-24" publication-format="electronic"><day>24</day><month>06</month><year>2013</year></pub-date><volume>6</volume><issue>2</issue><issue-title xml:lang="ru"/><fpage>175</fpage><lpage>187</lpage><history><date date-type="received" iso-8601-date="2016-04-27"><day>27</day><month>04</month><year>2016</year></date><date date-type="accepted" iso-8601-date="2016-04-27"><day>27</day><month>04</month><year>2016</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2013, Voronezh N.N. Burdenko State Medical University</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2013, ФГБОУ ВО ВГМУ им. Н.Н. Бурденко Минздрава России</copyright-statement><copyright-year>2013</copyright-year><copyright-holder xml:lang="en">Voronezh N.N. Burdenko State Medical University</copyright-holder><copyright-holder xml:lang="ru">ФГБОУ ВО ВГМУ им. Н.Н. Бурденко Минздрава России</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://vestnik-surgery.com/journal/about/editorialPolicies</ali:license_ref></license></permissions><self-uri xlink:href="https://vestnik-surgery.com/journal/article/view/202">https://vestnik-surgery.com/journal/article/view/202</self-uri><abstract xml:lang="en"><p>Relevance One of the features of traumatic epidemic peace time is an increase in the frequency of injuries of the organs of the abdominal cavity. Abdominal trauma occupy one of the per-out places in the structure of injuries of various systems of the body, and their frequency is 12-40,5%. In Western European countries in peace-time the specific weight of abdominal injury reaches 1.5-4.4% of all injuries. In different regions of our country the abdominal trauma falls from 1.5 to 36.5% from the number of injuries peace time, but their frequency and severity, in spite of the tendency to decrease, remain high. Injuries of parenchymatous organs are one of the most severe types of surgical pathology, both in peacetime and in wartime. The condition of the injured is determined by the multiplicity damage of parenchymatous organs, as well as the volume and intensity of blood loss. One of actual problems of surgery at the present time is to stop the bleeding in the event of damage of the liver, spleen. The purpose of the study To explore, experiment and make a comparative assessment of cryotherapy and some local applicator means of hemostasis in wounds of the liver and spleen. Materials and methods The paper presents experimental data showing changes in the tissue of liver and spleen under low temperature (-195,75°С) when modeling the wounds of various depth and length of the given organs. Simultaneously, in the control group the use of some of the adhesive hemostatic agents in cases of liver and spleen injury on a equatable number of experimental animals was evaluated. In all of the cases a histological study of areas of cryoapplication and adhesion of local hemostasiс agents was conducted. Results and their discussion It was proven that it takes significantly less time for hemostasis with the help of cryoapplication in comparison with hemostatic sponges. In addition to that, cryogenic method has antiadhesive activity and to a lesser extent causes inflammatory changes in the tissues as well as it allows for the formation of connective tissue in the place of the stoppage of bleeding significantly faster. Conclusions Local cryohemostasis can be used in cases of parenchymatous hemorrhage for an ultimate or temporary hemostasis. Proven lesser degree of severity of inflammatory changes when using cryohemostasis and showed a significant decrease in inflammatory reaction after cryohemostasis in the early stages of the experiment, which is not observed when using hemostatic sponge.</p></abstract><trans-abstract xml:lang="ru"><p>Актуальность Одной из особенностей травматической эпидемии мирного времени является увеличение частоты травм органов брюшной полости. Травмы живота занимают одно из первых мест в структуре травм различных систем орга- низма, и их частота составляет 12-40,5%. В западноевропейских странах в мирное время удельный вес абдоминальной травмы достигает 1,5–4,4% от всех травматических повреждений. В различных регионах нашей страны на повреждения живота приходится от 1,5 до 36,5% от числа травм мирного времени, а их частота и тяжесть, несмотря на тенденцию к снижению, остаются высокими. Ранения и травмы паренхиматозных органов являются одним из наиболее тяжелых видов хирургической патологии, как в мирное, так и в военное время. Тяжесть состояния пострадавших определяется мно- жественностью и сочетанностью повреждений паренхиматозных органов, а также объёмом и интенсивностью крово- потери. Одной из актуальных проблем хирургии в настоящее время является остановка кровотечения при повреждениях печени, селезенки. Цель исследования Изучить в эксперименте и провести сравнительную оценку криовоздействия и некоторых местных аппликационных средств гемостаза при ранениях печени и селезенки. Материалы и методы В работе представлены экспериментальные данные, говорящие об изменениях в ткани печени и селезенки под действием низкой температуры (-195,75°С) в условиях моделирования ранений данных органов различной глубины и протяженности. Одновременно в группе сравнения произведена оценка применения некоторых аппликационных средств гемостаза при ранениях печени и селезенки на сопоставимом количестве экспериментальных животных. Во всех наблюдениях произведено гистологическое исследование мест криоаппликации и адгезии средств местного гемостаза. Результаты и их обсуждение Доказано, что время достижения гемостаза с помощью криоаппликаций значительно мень- ше по сравнению с изучаемыми гемостатическими губками, а также криогенный метод обладает антиадгезивной актив- ностью и в меньшей степени вызывает воспалительные изменения в тканях, в более ранние сроки приводит к образованию соединительной ткани в месте остановки кровотечения. Выводы Локальный криогемостаз может применяться при паренхиматозных кровотечениях для окончательного или вре- менного гемостаза. Доказана меньшая выраженность степени воспалительных изменений при использовании криовоздейс- вия и отмечено достоверное снижение воспалительной реакции после криогемостаза на ранних сроках эксперимента, чего не наблюдается при использовании гемостатических губок.</p></trans-abstract><kwd-group xml:lang="en"><kwd>Liver and spleen damage</kwd><kwd>adhesive hemostatic agents</kwd><kwd>local cryohemostasis</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>Повреждения печени и селезенки</kwd><kwd>аппликационные средства гемостаза</kwd><kwd>локальный криогемостаз</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>1. 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