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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="other" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Journal of Experimental and Clinical Surgery</journal-id><journal-title-group><journal-title xml:lang="en">Journal of Experimental and Clinical Surgery</journal-title><trans-title-group xml:lang="ru"><trans-title>Вестник экспериментальной и клинической хирургии</trans-title></trans-title-group></journal-title-group><issn publication-format="print">2070-478X</issn><issn publication-format="electronic">2409-143X</issn><publisher><publisher-name xml:lang="en">Voronezh State Medical University named after N.N. Burdenko</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">219</article-id><article-id pub-id-type="doi">10.18499/2070-478X-2013-6-2-227-233</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Original articles</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Оригинальные статьи</subject></subj-group><subj-group subj-group-type="article-type"><subject>Unknown</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Acute Pancreatitis. Results of Surgical Treatment</article-title><trans-title-group xml:lang="ru"><trans-title>Острый панкреатит. Результаты хирургического лечения</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name><surname>Хрупкин</surname><given-names>В.И</given-names></name><bio xml:lang="en"><p>MD, Prof. of the Department of General Surgery of the First Moscow State Medical University named after I.M.Sechenov</p></bio><bio xml:lang="ru"><p>д.м.н., проф., глав- ный врач 23 Городской клинической больницы им. "Медсантруд"</p></bio><email>Valeriy20132@gmail.com</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name><surname>Афанасьев</surname><given-names>А.Н</given-names></name><bio xml:lang="en"><p>MD, Prof. of the Department of General Surgery of the First Moscow State Medical University named after I.M.Sechenov, Head. 3rd Surgical Department 23 City Clinical Hospital. Medsantrud</p></bio><bio xml:lang="ru"><p>д.м.н., проф. кафедры общей хирургии Первого Московского государственного медицинского университета им. И.М.Сеченова, зав. 3-м хирургическим отделением 23 Городской клинической больницы им. "Медсан- труд"</p></bio><email>afansurg@rambler.ru</email><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><name><surname>Фролков</surname><given-names>В.В</given-names></name><bio xml:lang="en"><p>Head. Intensive Care Unit 23 City Clinical Hospital. Medsantrud</p></bio><bio xml:lang="ru"><p>заведующий отде- ления реанимации и анестезиологии 23 Городской клинической больницы им. "Медсантруд"</p></bio><email>author@vestnik-surgery.com</email><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><name><surname>Шалыгин</surname><given-names>А.Б</given-names></name><bio xml:lang="en"><p>Ph.D., ass. Department of General Surgery of the First Moscow State Medical University. Sechenov, a surgeon third surgical unit 23 of the City Clinical Hospital. Medsantrud</p></bio><bio xml:lang="ru"><p>к.м.н., асс. кафе- дры общей хирургии Первого Московского го- сударственного медицинского университета им. И.М.Сеченова, врач-хирург 3-его хирургического отделения 23 Городской клинической больницы им. "Медсантруд"</p></bio><email>author@vestnik-surgery.com</email><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><name><surname>Кириллин</surname><given-names>А.В</given-names></name><bio xml:lang="en"><p>MD, ass. Department of General Surgery of the First Moscow State Medical University. Sechenov, a surgeon third surgical unit 23 of the City Clinical Hospital Medsantrud</p></bio><bio xml:lang="ru"><p>к.м.н., асс. кафедры общей хирургии Первого Московского государственного медицинского университета им. И.М.Сеченова, врач-хирург 3-его хирургического отделения 23 Городской клинической больницы им. "Медсантруд"</p></bio><email>author@vestnik-surgery.com</email><xref ref-type="aff" rid="aff2"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">City Clinical Hospital № 23 named Medsantrud, Moscow, Russian Federation</institution></aff><aff><institution xml:lang="ru">Городская клиническая больница №23 им. "Медсантруд", Москва, Российская Федерация</institution></aff></aff-alternatives><aff-alternatives id="aff2"><aff><institution xml:lang="en">I.M.Sechenov First Moscow State Medical University, Moscow, Russian Federation</institution></aff><aff><institution xml:lang="ru">Первый Московский государственный медицинский университет им. И.М.Сеченова, Москва, Российская Федерация</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2013-06-24" publication-format="electronic"><day>24</day><month>06</month><year>2013</year></pub-date><volume>6</volume><issue>2</issue><issue-title xml:lang="ru"/><fpage>227</fpage><lpage>233</lpage><history><date date-type="received" iso-8601-date="2016-04-27"><day>27</day><month>04</month><year>2016</year></date><date date-type="accepted" iso-8601-date="2016-04-27"><day>27</day><month>04</month><year>2016</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2013, ., ., ., ., .</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2013, Хрупкин В., Афанасьев А., Фролков В., Шалыгин А., Кириллин А.</copyright-statement><copyright-year>2013</copyright-year><copyright-holder xml:lang="en">., ., ., ., .</copyright-holder><copyright-holder xml:lang="ru">Хрупкин В., Афанасьев А., Фролков В., Шалыгин А., Кириллин А.</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">http://creativecommons.org/licenses/by-nc-nd/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://vestnik-surgery.com/journal/article/view/219">https://vestnik-surgery.com/journal/article/view/219</self-uri><abstract xml:lang="en"><p>The purpose of the study To analyze the results of the treatment of patients with acute destructive pancreatitis and determine the most effective methods of various drainage operations to decrease the number of complications and mortality rates as well as improve treatment outcomes. Materials and methods The results of the treatment of 1433 patients, among whom 136 (9,5%) had various forms of acute destructive pancreatitis, were analyzed. The basic complex conservative therapy during the study period was consistent and included antisecretory, infusion, antiulcer, antibacterial, corrective therapy, extracorporeal detoxification methods. At admission, the general condition of 49 patients (36,3%) was viewed as moderate, of 46 patients (34,2%) – as serious and of 33 patients (24,5%) – as extremely difficult. Results and their discussion In case of primary destruction of the pancreatic tissue and parapancreatic cellulose of less than 30%, conservative therapy, extracorporeal detoxification methods along with minimally invasive surgery proved to be effective in 91,1% of the cases. In 8,9% of the cases, additional minimally invasive "closed" drainages of the local suppurative complications were required. The prolonged epidural analgesia was applied to all patients during the complex treatment, regardless of the number of destructive changes and severe course of the disease, starting from the first days. The general stages of surgical intervention for patients with severe acute destructive pancreatitis during the early development of both aseptic as well as early and late unlimited postnecrotic septic complications were developed. Conclusion A differentiated approach to the surgical treatment strategy of the patients with destructive pancreatitis, depending on the amount of the initial lesion of the pancreas, allowed to reduce the average number of suppurative complications by 4 times per patient (from 9,8 to 2,2%) and decrease the mortality rates by 3 times from suppurative complications.</p></abstract><trans-abstract xml:lang="ru"><p>Цель исследования Проанализировать результаты лечения больных с острым деструктивным панкреатитом и опре- делить наиболее эффективные методы различных дренирующих операций с целью уменьшения количества осложнений, снижения летальности и улучшения исходов заболевания. Материалы и методы Анализированы результаты лечении 1433 больных, из которых у 136 (9,5%) выявлены различные формы острого деструктивного панкреатита. Базисная комплексная консервативная терапия в анализируемом периоде была одинаковой и включала антисекреторную, инфузионную, противоязвенную, антибактериальную, корригирующую те- рапию, методы экстракорпоральной детоксикаци. При поступлении у 49 (36,3%) больных общее состояние расценили как средней тяжести, у 46 (34,2%) – тяжелое, у 33 (24,5%) – крайне тяжелое. Результаты и их обсуждение Консервативная терапия, экстракорпоральная детоксикация с использованием методов малоинвазивной хирургии, при первичной деструкции ткани поджелудочной железы и парапанкреатической клетчатки менее 30% оказались эффективными в 91,1% случаев. В 8,9% потребовались дополнительные малоинвазивные «закрытые» дренирования локальных гнойных осложнений. Всем больным, независимо от объема деструктивных изменений и тяже- лым течением заболевания, начиная с первых суток от начала, в комплексе лечения применена продленная эпидуральная анальгезия. Разработаты общие этапы оперативных вмешательств у больных с тяжелым течением острого деструк- тивного панкреатита в период развития как ранних асептических, так и ранних и поздних неотграниченных постнекро- тических септических осложнений. Выводы Поражение поджелудочной железы более 30% сопровождается неотграниченными гнойными осложнениями, что требует выполнения лапапаротомии с последующим «открытым» дренированием очагов деструкции. Дифферен- цированный подход к хирургической тактике лечения больных деструктивным панкреатитом, в зависимости от объема первоначального поражения поджелудочной железы, позволил в среднем уменьшить число гнойных осложнений на одного больного в 4 раза (с 9,8 до 2,2%), снизить летальность от гнойных осложнений в 3 раза.</p></trans-abstract><kwd-group xml:lang="en"><kwd>Acute pancreatitis</kwd><kwd>surgical approach</kwd><kwd>drainage</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>Острый панкреатит</kwd><kwd>хирургическая тактика</kwd><kwd>дренирование</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>1. Aleksandrova D.A. Lecheniye Pankreonekroz,</mixed-citation></ref><ref id="B2"><label>2.</label><mixed-citation>Rassmotreniye variantov razrusheniya podzheludochnoy zhelezy i</mixed-citation></ref><ref id="B3"><label>3.</label><mixed-citation>zabryushinnogo prostranstva [Pancreatonecrosis treatment,</mixed-citation></ref><ref id="B4"><label>4.</label><mixed-citation>considering options of destruction of pancreas and</mixed-citation></ref><ref id="B5"><label>5.</label><mixed-citation>retroperitoneal space]. Voenno-meditsinskii zhurnal, 2003;</mixed-citation></ref><ref id="B6"><label>6.</label><mixed-citation>9: 60. – (In Russian).</mixed-citation></ref><ref id="B7"><label>7.</label><mixed-citation>2. Afendulov S.A., Zhuravlev G.Iu., Gadzhiev A.U.,</mixed-citation></ref><ref id="B8"><label>8.</label><mixed-citation>Nazola V.A. Minimal'no invazivnyye tekhnologii v</mixed-citation></ref><ref id="B9"><label>9.</label><mixed-citation>Lecheniye pankreonekroza [Minimally invasive technologies in</mixed-citation></ref><ref id="B10"><label>10.</label><mixed-citation>treatment of pancreatic necrosis]. XII Vserossiiskii s"ezd</mixed-citation></ref><ref id="B11"><label>11.</label><mixed-citation>endoskopicheskikh khirurgov [12th All-Russian Cong.</mixed-citation></ref><ref id="B12"><label>12.</label><mixed-citation>Endosc. Surg.]. Moscow, 2009, 119. – (In Russian).</mixed-citation></ref><ref id="B13"><label>13.</label><mixed-citation>3. Briskin B.S., Rybakov G.S., Khalidov O.Kh. Taktika</mixed-citation></ref><ref id="B14"><label>14.</label><mixed-citation>septicheskikh gnoynykh oslozhneniy pankreonekroza [The tactic of</mixed-citation></ref><ref id="B15"><label>15.</label><mixed-citation>septic purulent complications of pancreonecrosis]. Materialy</mixed-citation></ref><ref id="B16"><label>16.</label><mixed-citation>kongressa «Tretii kongress Assotsiatsii khirurgov im. N.I.</mixed-citation></ref><ref id="B17"><label>17.</label><mixed-citation>Pirogova» [Proc. kongress "3rd Congress of Association of</mixed-citation></ref><ref id="B18"><label>18.</label><mixed-citation>Surgeons named after N.I. Pirogov"]. Moscow, 2001, 105.</mixed-citation></ref><ref id="B19"><label>19.</label><mixed-citation>– (In Russian).</mixed-citation></ref><ref id="B20"><label>20.</label><mixed-citation>4. Gal'perin E.I., Dokuchaev K.V. Pogosian G.S. Pankreatit</mixed-citation></ref><ref id="B21"><label>21.</label><mixed-citation>i parapancreatonecrosis: kogda rabotat' i chto delat'? [Pancreatitis</mixed-citation></ref><ref id="B22"><label>22.</label><mixed-citation>and parapancreatonecrosis: when to operate and what to do?]</mixed-citation></ref><ref id="B23"><label>23.</label><mixed-citation>Materialy IX Vserossiiskogo s"ezda khirurgov [Materials of the IX All-Russian congress of surgeons]. Volgograd, 2000,</mixed-citation></ref><ref id="B24"><label>24.</label><mixed-citation>31. – (In Russian).</mixed-citation></ref><ref id="B25"><label>25.</label><mixed-citation>5. Gostishchev V.K., Glushko V.A. Pankreonekroz i</mixed-citation></ref><ref id="B26"><label>26.</label><mixed-citation>yego oslozhneniya, osnovnyye printsipy khirurgicheskoy taktiki [ Pancreonecrosis and</mixed-citation></ref><ref id="B27"><label>27.</label><mixed-citation>its complications, the basic principles of surgical tactics].</mixed-citation></ref><ref id="B28"><label>28.</label><mixed-citation>Khirurgiia, 2003; 3: 50-54. – (In Russian).</mixed-citation></ref><ref id="B29"><label>29.</label><mixed-citation>6. Zatevakhin I.I., Tsitsiashvili M.Sh., Budurova M.D. Diagnostika i lecheniye pankreonekroza: reshena i</mixed-citation></ref><ref id="B30"><label>30.</label><mixed-citation>nereshennykh voprosov</mixed-citation></ref><ref id="B31"><label>31.</label><mixed-citation>[Diagnosis and treatment of pancreonecrosis: solved and</mixed-citation></ref><ref id="B32"><label>32.</label><mixed-citation>unsolved questions]. Materialy IX Vserossiiskogo s"ezda</mixed-citation></ref><ref id="B33"><label>33.</label><mixed-citation>khirurgov [Proc. of the IX All-Russian Congress of</mixed-citation></ref><ref id="B34"><label>34.</label><mixed-citation>Surgeons]. Volgograd, 2000, 48-49. – (In Russian).</mixed-citation></ref><ref id="B35"><label>35.</label><mixed-citation>7. Lysenko M.V., Ursov S.V., Ps'ko V.G., Chizh S.I., Gritsiuk</mixed-citation></ref><ref id="B36"><label>36.</label><mixed-citation>A.M., Litovchenko G.Ia. Differentsirovannaia lechebnodiagnosticheskaia taktika pri ostrom pankreatite Differentsial'nyy lecheniye i diagnosticheskaya taktika pri ostrom</mixed-citation></ref><ref id="B37"><label>37.</label><mixed-citation>pankreatit</mixed-citation></ref><ref id="B38"><label>38.</label><mixed-citation>[Differential treatment and diagnostic tactics in acute</mixed-citation></ref><ref id="B39"><label>39.</label><mixed-citation>pancreatitis]. Moscow, GVKG im. N.N. Burdenko, 2007. 14</mixed-citation></ref><ref id="B40"><label>40.</label><mixed-citation>p. – (In Russian).</mixed-citation></ref><ref id="B41"><label>41.</label><mixed-citation>8. Prudkov M.I., Shulutko A.M., Galimzianov F.V., Levit A.L.</mixed-citation></ref><ref id="B42"><label>42.</label><mixed-citation>Minimal'no invazivnaia khirurgiia nekrotiziruiushchego</mixed-citation></ref><ref id="B43"><label>43.</label><mixed-citation>pankreatita. Posobie dlia vrachei [The minimum invasive surgery of of necrotizing pancreatitis. Guidance for</mixed-citation></ref><ref id="B44"><label>44.</label><mixed-citation>practitioners]. Ekaterinburg, 2001; 47 p. – (In Russian).</mixed-citation></ref><ref id="B45"><label>45.</label><mixed-citation>9. Pugaev A.V., Shipilov D.V., Travnikova N.L. Otsenka</mixed-citation></ref><ref id="B46"><label>46.</label><mixed-citation>perspektiv prokola lecheniya pankreaticheskikh</mixed-citation></ref><ref id="B47"><label>47.</label><mixed-citation>lozhnaya kista [Assessing</mixed-citation></ref><ref id="B48"><label>48.</label><mixed-citation>of prospects of the puncture treatment of pancreatic</mixed-citation></ref><ref id="B49"><label>49.</label><mixed-citation>pseudocyst]. Annaly khirurgicheskoi gepatologii, 1996; 1:</mixed-citation></ref><ref id="B50"><label>50.</label><mixed-citation>165. – (In Russian).</mixed-citation></ref><ref id="B51"><label>51.</label><mixed-citation>10. Torbunov A.S., Sorokin D.K., Piskun A.B. Rol'</mixed-citation></ref><ref id="B52"><label>52.</label><mixed-citation>minimal'no invazivnoy khirurgii v lechenii bol'nykh</mixed-citation></ref><ref id="B53"><label>53.</label><mixed-citation>ostryy destruktivnyy pankreatit [The role</mixed-citation></ref><ref id="B54"><label>54.</label><mixed-citation>of minimally invasive surgery in the treatment of the</mixed-citation></ref><ref id="B55"><label>55.</label><mixed-citation>acute destructive pancreatitis]. XII Vserossiiskii s"ezd</mixed-citation></ref><ref id="B56"><label>56.</label><mixed-citation>endoskopicheskikh khirurgov [XII All-Russian Congress</mixed-citation></ref><ref id="B57"><label>57.</label><mixed-citation>of Endoscopic Surgeons]. Moscow, 2009; 78. – (In Russian).</mixed-citation></ref><ref id="B58"><label>58.</label><mixed-citation>11. Savel'ev B.C., Gel'fand B.R., Filimonov M.I. Zarazhennyy</mixed-citation></ref><ref id="B59"><label>59.</label><mixed-citation>Pankreonekroz [The infected</mixed-citation></ref><ref id="B60"><label>60.</label><mixed-citation>Pancreatonecrosis]. Infektsiia v khirurgii, 2003; 1: 2: 34-39.</mixed-citation></ref><ref id="B61"><label>61.</label><mixed-citation>– (In Russian).</mixed-citation></ref><ref id="B62"><label>62.</label><mixed-citation>12. Gloor B. Uhl W., Muller C.A. et al. Rol' khirurgii v</mixed-citation></ref><ref id="B63"><label>63.</label><mixed-citation>Upravleniye ostrogo pankreatita [The role of surgery in the</mixed-citation></ref><ref id="B64"><label>64.</label><mixed-citation>management of acute pancreatitis]. Can. J. Gastroenterol,</mixed-citation></ref><ref id="B65"><label>65.</label><mixed-citation>2004; 11, 14.</mixed-citation></ref><ref id="B66"><label>66.</label><mixed-citation>13. Hamand G.G., Broderick T.J. Laparoskopicheskaya podzheludochnoy zhelezy</mixed-citation></ref><ref id="B67"><label>67.</label><mixed-citation>Nekrektomiya [Laparoscopic pancreatic</mixed-citation></ref><ref id="B68"><label>68.</label><mixed-citation>Necrosectomy]. Am. J. Surgery, 2002; 10 (2): 115-8.</mixed-citation></ref></ref-list></back></article>
