<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE root>
<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="other" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Journal of Experimental and Clinical Surgery</journal-id><journal-title-group><journal-title xml:lang="en">Journal of Experimental and Clinical Surgery</journal-title><trans-title-group xml:lang="ru"><trans-title>Вестник экспериментальной и клинической хирургии</trans-title></trans-title-group></journal-title-group><issn publication-format="print">2070-478X</issn><issn publication-format="electronic">2409-143X</issn><publisher><publisher-name xml:lang="en">Voronezh State Medical University named after N.N. Burdenko</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">302</article-id><article-id pub-id-type="doi">10.18499/2070-478X-2012-5-4-722-726</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Review of literature</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Обзор литературы</subject></subj-group><subj-group subj-group-type="article-type"><subject>Unknown</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Endogenous intoxication syndrome and system inflammatory reaction in choleperitonitis, complicated by abdominal sepsis</article-title><trans-title-group xml:lang="ru"><trans-title>Синдром эндогенной интоксикации и системной воспалительной реакции при желчном перитоните, осложненном абдоминальным сепсисом</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name><surname>Терещенко</surname><given-names>О.А.</given-names></name><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Кубанский государственный медицинский университет Научно-исследовательский институт физико-химической медицины, г. Москва Институт молекулярных наук им. А.И.Виртанена Университет Восточной Финляндии, Куопио, Финляндия</p></bio><bio xml:lang="ru"><p>Терещенко Олег Анатольевич – к.м.н., зав. отд. дет- ской хирургии Детской краевой клинической боль- ницы, г. Краснодар</p></bio><email>superego_ksmu@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name><surname>Боташев</surname><given-names>А.А.</given-names></name><address><country country="RU">Russian Federation</country></address><bio xml:lang="ru"><p>Боташев Алибек Амырбиевич – к.м.н., докторант кафедры оперативной хирургии и топографической анатомии Кубанского государственного медицинского университета</p></bio><email>author@vestnik-surgery.com</email><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><name><surname>Помещик</surname><given-names>Ю.В.</given-names></name><address><country country="RU">Russian Federation</country></address><bio xml:lang="ru"><p>Помещик Юрий Владимирович – к.м.н., научный сотрудник отдела нейробиологии Института мо- лекулярных наук им. А.И.Виртанена, Университет Восточной Финляндии</p></bio><email>yuriy.pomeshchik@mail.ru</email><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><name><surname>Петросян</surname><given-names>Э.A.</given-names></name><address><country country="RU">Russian Federation</country></address><bio xml:lang="ru"><p>Петросян Эдуард Арутюнович – д.м.н., проф., зав. кафедрой оперативной хирургии и топографиче- ской анатомии Кубанского государственного ме- дицинского университета</p></bio><email>superego_ksmu@mail.ru</email><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><name><surname>Сергиенко</surname><given-names>В.И.</given-names></name><address><country country="RU">Russian Federation</country></address><bio xml:lang="ru"><p>Сергиенко Валерий Иванович – д.м.н., проф., ака- демик РАМН, директор научно-исследовательского института физико-химической медицины, г. Мо- сква</p></bio><email>vll@pochta.ru</email><xref ref-type="aff" rid="aff2"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en"></institution></aff><aff><institution xml:lang="ru">Кубанский государственный медицинский университет Научно-исследовательский институт физико-химической медицины, г. Москва Институт молекулярных наук им. А.И.Виртанена Университет Восточной Финляндии, Куопио, Финляндия</institution></aff></aff-alternatives><aff id="aff2"><institution></institution></aff><pub-date date-type="pub" iso-8601-date="2012-12-24" publication-format="electronic"><day>24</day><month>12</month><year>2012</year></pub-date><volume>5</volume><issue>4</issue><issue-title xml:lang="ru"/><fpage>722</fpage><lpage>726</lpage><history><date date-type="received" iso-8601-date="2016-04-28"><day>28</day><month>04</month><year>2016</year></date><date date-type="accepted" iso-8601-date="2016-04-28"><day>28</day><month>04</month><year>2016</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2012, ., ., ., ., .</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2012, Терещенко О., Боташев А., Помещик Ю., Петросян Э., Сергиенко В.</copyright-statement><copyright-year>2012</copyright-year><copyright-holder xml:lang="en">., ., ., ., .</copyright-holder><copyright-holder xml:lang="ru">Терещенко О., Боташев А., Помещик Ю., Петросян Э., Сергиенко В.</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">http://creativecommons.org/licenses/by-nc-nd/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://vestnik-surgery.com/journal/article/view/302">https://vestnik-surgery.com/journal/article/view/302</self-uri><abstract xml:lang="en"><p>Кубанский государственный медицинский университет Научно-исследовательский институт физико-химической медицины, г. Москва Институт молекулярных наук им. А.И.Виртанена Университет Восточной Финляндии, Куопио, Финляндия</p></abstract><trans-abstract xml:lang="ru"><p>Кубанский государственный медицинский университет Научно-исследовательский институт физико-химической медицины, г. Москва Институт молекулярных наук им. А.И.Виртанена Университет Восточной Финляндии, Куопио, Финляндия</p></trans-abstract><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Beliakov N.A., Miroshnichenko A.G., Malakhova M.Ia., Izotova O.G. Verifikatsiia endotoksikoza u bol'nykh s razlitym peritonitom.[Verification of endotoxicosis at patients with the poured peritonitis.]. Efferentnaia terapiia. 1995; 2: 14-19.</mixed-citation></ref><ref id="B2"><label>2.</label><mixed-citation>Bogdanov S.N., Butkevich A.Ts., Vorob'ev Iu.A. Khirurgicheskoe lechenie iatrogennykh povrezhdenii zhelchnykh protokov pri laparoskopicheskoi kholetsistektomii.[Surgical treatment the yatrogennykh of damages of bilious channels at a laparoscopic holetsistektomiya.]. Annaly khirurgicheskoi gepatologii. 2008; 3: 109-110.</mixed-citation></ref><ref id="B3"><label>3.</label><mixed-citation>Borisov A.E., Levin L.A., Kubachev K.G. Oslozhneniia laparoskopicheskoi kholetsistektomii.[Complications of a laparoscopic holetsistektomiya. ]. Endoskopicheskaia khirurgiia. 2001; 3: 34-40.</mixed-citation></ref><ref id="B4"><label>4.</label><mixed-citation>Valyshev A.V. i dr. Rol' persistiruiushchei uslovno-patogennoi mikroflory kishechnika pri disbioze v vozniknovenii zabolevanii gepatobiliarnoi sistemy.[Role of persistiruyushchy uslovnopatogenny intestinal microflora at a disbioza in developing of diseases gepatobilyarno systems.]. Mikrobiologiia, epidemiologiia i immunobiologiia. 1997; 4: 87-88.</mixed-citation></ref><ref id="B5"><label>5.</label><mixed-citation>Gallinger Iu.I., Karpenkova V.I. Laparoskopicheskaia kholetsistektomiia: opyt 3165 operatsii.[Laparoscopic holetsistektomiya: experience of 3165 operations.]. Endoskopicheskaia khirurgiia. 2007; 2: 3-7.</mixed-citation></ref><ref id="B6"><label>6.</label><mixed-citation>Gal'perin E.I., Vetshev P.S. Rukovodstvo po khirurgii zhelchnykh putei.[Guide to surgery of bilious ways.]. M. 2006; 568.</mixed-citation></ref><ref id="B7"><label>7.</label><mixed-citation>Galiamova S.V., Shirinskii V.G., Galiamov E.A. i dr. Oslozhneniia pri vypolnenii slozhnykh endokhirurgicheskikh vmeshatel'stv: sostoianie problemy.[Complications when performing difficult endosurgical interventions: condition of a problem.]. Endoskopicheskaia khirurgiia. 2008; 1: 25-29.</mixed-citation></ref><ref id="B8"><label>8.</label><mixed-citation>Genok V.Ia. Endoskopicheskie tekhnologii – metod profilaktiki oslozhnenii.[Endoscopic technologies - a method of prophylaxis of complications.]. Endoskopicheskaia khirurgiia. 2008; 3: 13-15.</mixed-citation></ref><ref id="B9"><label>9.</label><mixed-citation>Glukhov A.A., Koshelev P.I., Leibel's V.N. Lechenie «svezhikh» povrezhdenii vnepechenochnykh zhelchnykh protokov.[Treatment of fresh damages of extra hepatic bilious channels.]. Annaly khirurgicheskoi gepatologii. 2008; 3: 115-116.</mixed-citation></ref><ref id="B10"><label>10.</label><mixed-citation>Kalinina N.M., Drygina L.B., Sokolian N.A. Autoimmunnaia patologiia endoteliia.[Autoimmune pathology endoteliya]. Meditsinskaia immunologiia. 2004; 1-2: 25-36.</mixed-citation></ref><ref id="B11"><label>11.</label><mixed-citation>Kirsanova A.K. Mekhanizmy narusheniia funktsii endoteliia sosudov pri septicheskikh sostoianiiakh.[Malfunction mechanisms an endoteliya of vessels at septic states]. Anesteziologiia i reanimatologiia. 2003; 6: 72-75.</mixed-citation></ref><ref id="B12"><label>12.</label><mixed-citation>Krakovskii M.E., Ashirmetov A.X. Osnovnye patogeneticheskie mekhanizmy narusheniia intoksikatsii razlichnogo geneza.[Main pathogenetic mechanisms of violation of intoxication of various genesis.]. Vestnik AMN SSSR. 1989; 12: 70-76.</mixed-citation></ref><ref id="B13"><label>13.</label><mixed-citation>Kurbonov K.M., Daminova N.M. Diagnostika i taktika lecheniia posleoperatsionnogo zhelchnogo peritonita.[Diagnostics and tactics of treatment of postoperative bilious peritonitis]. Khirurgiia. 2007; 8: 38-42.</mixed-citation></ref><ref id="B14"><label>14.</label><mixed-citation>Likhoded V.G., Iushchuk N.D., Iakovlev M.Iu. Rol' endotoksina gramotritsatel'nykh bakterii v infektsionnoi i neinfektsionnoi patologii.[Endotoxin role the gramotritsatelnykh of bacteria in infectious and noninfectious pathology.]. Arkhiv patologii. M. 1996; 2: 8-13.</mixed-citation></ref><ref id="B15"><label>15.</label><mixed-citation>Salakhov I.M., Ipatov A.I., Konev Iu.V., Iakovlev M.Iu. Sovremennye aspekty patogeneza endotoksicheskogo shoka.[Modern aspects of pathogenesis of endotoxic shock.]. Uspekhi sovremennoi biologii. 1998; Vyp. 1: 33-50.</mixed-citation></ref><ref id="B16"><label>16.</label><mixed-citation>Sergienko V.I., Petrosian E.A., Botashev A.A., Tereshchenko O.A. Rol' sistemnoi vospalitel'noi reaktsii i endotelial'noi disfunktsii v patogeneze zhelchnogo peritonita.[Role of system inflammatory reaction and endotelialny dysfunction in pathogenesis of bilious peritonitis.]. Vestnik Volgogradskogo gosudarstvennogo meditsinskogo universiteta. 2011; 2: 60-63.</mixed-citation></ref><ref id="B17"><label>17.</label><mixed-citation>Sergienko V.I., Petrosian E.A., Botashev A.A., Tereshchenko O.A. Endotelial'naia disfunktsiia i metody ee korrektsii pri eksperimental'nom zhelchnom peritonite.[Endotelialny dysfunction and methods of her correction at experimental bilious peritonitis. ]. Khirurgiia. 2012; 3: 54-58.</mixed-citation></ref><ref id="B18"><label>18.</label><mixed-citation>Skvortsova T.E. Kliniko-patogeneticheskie osobennosti diagnostiki i lecheniia zhelchnokamennoi bolezni u bol'nykh s narusheniiami dvigatel'noi funktsii i mikrobiotsenoza kishechnika.[Kliniko-patogenetichesky features of diagnostics and treatment of a zhelchekamenny disease at patients with violations of motive function and a microbiocenosis of intestines.]. Avtoref. dis. …. kand. med. nauk. SPb. 2007; 24.</mixed-citation></ref><ref id="B19"><label>19.</label><mixed-citation>Freidlin I.S., Sheikin Iu.A. Endotelial'nye kletki v kachestve mishenei i produtsentov tsitokinov.[Endotelialny cages as targets and producers of tsitokin.]. Meditsinskaia immunologiia. 2001; 4: 499-514.</mixed-citation></ref><ref id="B20"><label>20.</label><mixed-citation>Chereshnev V.A., Gusev E.Iu., Iurchenko L.I. Sistemnoe vospalenie mif ili real'nost'?.[System inflammation: myth or reality?]. Vestnik RAN. 2004; 3: 219-225.</mixed-citation></ref><ref id="B21"><label>21.</label><mixed-citation>Shcherbakha N.A. Sostoianie fermentativnykh sistem miokarda v usloviiakh endogennoi intoksikatsii.[Condition of enzymatic systems of a myocardium in the conditions of an endogenous itoksikation. ]. Avtoref. dis. ... d-ra med. nauk. SPb. 1993; 44.</mixed-citation></ref><ref id="B22"><label>22.</label><mixed-citation>Adams J.M., Hauser S.J., Adams S.A. Jr. et al. Entry of gut lymph into the circulation primes rat neutrophil respiratory burst in hemorrhagic shock. Crit. CareMed. 2001; 29: 11: 2194-2198.</mixed-citation></ref><ref id="B23"><label>23.</label><mixed-citation>Aird W.C. The role of endothelium in severe sepsis and multiple organ dysfunction syndrome. Blood. 2003; 101: 10: 3765-3777.</mixed-citation></ref><ref id="B24"><label>24.</label><mixed-citation>Asea A., Rehli M., Kabingu E. et al. Novel signal transduction pathway utilized by extracellular HSP70: role of tolllike receptor (TLR) 2 and TLR4. J. Biol. Chem. 2002; 277: 17: 15028-15034.</mixed-citation></ref><ref id="B25"><label>25.</label><mixed-citation>Balkwill F. Cytokine amplification and inhibition on immune and inflammatory responses. J. Vira Hepatits. 1997; 4: 2: 6-15.</mixed-citation></ref><ref id="B26"><label>26.</label><mixed-citation>Bhattacharyya J., Biswas S., Datta A.G. Non-extensive thermodynamics, heavy ion collisions and particle production at RHICenergies. Curr. Med. Chem. 2004; 11: 3: 359-368.</mixed-citation></ref><ref id="B27"><label>27.</label><mixed-citation>Bhattacharyya S., Mandal D., Sen G.S. et al. Tumor-induced oxidative stress perturbs NFκB activity augmenting TNFα-mediated T cell death: protection by curcumin. Cancer Research. 2007: 67: 1: 362-370.</mixed-citation></ref><ref id="B28"><label>28.</label><mixed-citation>Binotto M.A., Maeda N.Y., Lopes A.A. Evidence of endothelial dysfunction in patients with functionally univentricular physiology before completion of the Fontan operation. Cardiol. young. 2005; 15: 1: 26-30.</mixed-citation></ref><ref id="B29"><label>29.</label><mixed-citation>Bone R.C. Modulators of coagulation. A critical appraisal of ther rolein sepsis. Arch. Intern. Med. 1992; 152: 7: 1381-1389.</mixed-citation></ref><ref id="B30"><label>30.</label><mixed-citation>Bone R.C. Immunologic dissonance: a continuing evolution in our understanding of the systemic inflammatory response syndrome (SIRS) and the multiple organ dysfunction syndrome (MODS). Ann. Intern. Med. 1996; 125: 8: 680-687.</mixed-citation></ref><ref id="B31"><label>31.</label><mixed-citation>Bottiger B.W., Motsch J., Braun V. et al. Marked activation of complement and leukocytes and an increase in the concentrations of soluble endothelial adhesion molecules during cardiopulmonary resuscitation and early reperfusion after cardiac arrest in humans. Critical Care Medicine. 2002; 30: 11: 2473-2480.</mixed-citation></ref><ref id="B32"><label>32.</label><mixed-citation>Brown D.M., Hutchison L., Donaldson K. et al. The effect of oxidative stress on macrophages and lung epithelial cells: the role of phosphodiesterases 1 and 4. Toxicol. lett. 2007; 168: 1: 1-6.</mixed-citation></ref><ref id="B33"><label>33.</label><mixed-citation>Bultinck J., Brouckaert P., Cauwels A. The in vivo contribution of hematopoietic cells to systemic TNF and IL-6 production during endotoxemia. Cytokine. 2006; 36: 3-4: 160-166.</mixed-citation></ref><ref id="B34"><label>34.</label><mixed-citation>Cines D.B., Pollak E.S., Buck C.A. et al. Endothelial cells in physiology and in the pathophysiology of vascular disorders. Blood. 1998; 91: 10: 3527-3561.</mixed-citation></ref><ref id="B35"><label>35.</label><mixed-citation>De Martin R., Hoeth M., Hofer-Warbinek R., Schmid J.A. The transcription factor NF-kappa B and the regulation of vascular cell function. Arterioscler. Thromb. Vasc. Biol. 2000; 20: 11: 883-888.</mixed-citation></ref><ref id="B36"><label>36.</label><mixed-citation>Dichtl W., Dulak J., Frick M. et al. HMG-CoA reductase inhibitors regulate inflammatory transcription factors in human endothelial and vascular smooth muscle cells. Arterioscler. Thromb. Vasc. Biol. 2003; 23: 1: 58-63.</mixed-citation></ref><ref id="B37"><label>37.</label><mixed-citation>Hack C.E., Zeerleder S. The endothelium in sepsis: source of and a target for inflammation. Crit. Care Med. 2001; 29: 7: 521-527.</mixed-citation></ref><ref id="B38"><label>38.</label><mixed-citation>Hajjar K.A., Deora A. New concepts in fibrinolysis and angiogenesis. Curr. Atheroscler. Rep. 2000; 2: 5: 417-421.</mixed-citation></ref><ref id="B39"><label>39.</label><mixed-citation>Hao W.L., Lee Y.K. Microflora of the gastrointestinal tract: a review. Methods Mol Biol. 2004; 268: 491-502.</mixed-citation></ref><ref id="B40"><label>40.</label><mixed-citation>Harlan J.M., Winn R.K. Leukocyte-endothelial interactions: clinical trials of anti-adhesion therapy. Crit. Care Med. 2002; 30: 5: 5214-5219.</mixed-citation></ref><ref id="B41"><label>41.</label><mixed-citation>Hiki N., Mimura Y., Ogawa T. et al. Pathophysiological relevance of the CD14 receptor in surgical patients: biological activity of endotoxin is regulated by the CD14 receptor. Innate Immunity. 2001; 7: 6: 461-466.</mixed-citation></ref><ref id="B42"><label>42.</label><mixed-citation>Levi M., ten Cate H., Van der Poll T. Endothelium: interface between coagulation and inflammation. Crit. Care Med. 2002; 30: 5: 220-224.</mixed-citation></ref><ref id="B43"><label>43.</label><mixed-citation>Mantovani A., Garlanda C., Introna M., Vecchi A. Regulation of endothelial cell function by proand anti-inflammatory cytokines. Transplant. Proc. 1998; 30: 8: 4239-4243.</mixed-citation></ref><ref id="B44"><label>44.</label><mixed-citation>Meager A. Cytokine regulation of cellular adhesion mole cule expression in inflammation. Cytokine Growth Factor Rew. 1999; 10: 1: 27-39.</mixed-citation></ref><ref id="B45"><label>45.</label><mixed-citation>Mercie P., Belloc F., Bihlou-Nabera S. et al. J. Lab. Clin. Med. 2000; 136: 402-411.</mixed-citation></ref><ref id="B46"><label>46.</label><mixed-citation>Mukaiya M. et al. Isolated bacteria and susceptibilities to antimicrobial agents in biliary infections. Hepatogastroenterology. 2005; 52: 63: 686-690.</mixed-citation></ref><ref id="B47"><label>47.</label><mixed-citation>Nieto N. Modulation of reactive oxygen species in endothelial cells by peroxynitritetreated lipoproteins. Hepatology. 2006; 44: 6: 1487- 1501.</mixed-citation></ref><ref id="B48"><label>48.</label><mixed-citation>Niu J., Chang Z., Peng B. et al. Keratinocyte growth factor/fibroblast growth factor-7-regulated cell migration and invasion through activation of NF-kappaB transcription factors. J. Biol. Chem. 2007; 282: 9: 6001-6011.</mixed-citation></ref><ref id="B49"><label>49.</label><mixed-citation>Paterson R.L., Webster N.R. Sepsis and the systemic inflammatory response syndrome. J. Roy. Coll. Surg. Edinb. 2000; 45: 6: 178-182.</mixed-citation></ref><ref id="B50"><label>50.</label><mixed-citation>Peng H.B., Spiecker M., Liao J.K. Inducible nitric oxide: an autoregulatory feedback inhibitor of vascular inflammation. J. Immunol. 1998; 161: 4: 1970-1976.</mixed-citation></ref><ref id="B51"><label>51.</label><mixed-citation>Pladzyk A., Reddy M., Yadav U.C. et al. Inhibition of Aldose Reductase Prevents Lipopolysaccharide-Induced Inflammatory Response in Human Lens Epithelial Cells Inves. Invest. Ophthalmol. Vis. Sci. 2006; 47: 12: 5395-5403.</mixed-citation></ref><ref id="B52"><label>52.</label><mixed-citation>Reinhart K., Bayer O., Brunkhorst F., Meisner M. Markers of endothelial damage in organ dysfunction and sepsis. Crit. Care Med. 2002; 30: 5: 302-312.</mixed-citation></ref><ref id="B53"><label>53.</label><mixed-citation>Saadane A., Masters S., Didonato J. et al. Parthenolide inhibits IkappaB kinase, NF-kappaB activation, and inflammatory response in cystic fibrosis cells and mice. Am. J. Respir.Cell. Mol. Biol. 2007; 36: 6: 728-736.</mixed-citation></ref><ref id="B54"><label>54.</label><mixed-citation>Shan Y.X., Jin S.Z., Liu Y., Liu S.Z. Ionizing radiation stimulates secretion of proinflammatory cytokines: dose-response relationship, mechanisms and implications. Radiat. Environ. Biophys. 2006; 46: 1: 21-29.</mixed-citation></ref><ref id="B55"><label>55.</label><mixed-citation>Sun H.V., Yokota H. Reduction of cytokine-induced expression and activity of MMP-1 and MMP-13 by mechanical strain in MH7A rheumatoid synovial cells. Matrix Biol. 2002; 21: 3: 263-270.</mixed-citation></ref><ref id="B56"><label>56.</label><mixed-citation>Thomas X., Campos L., Mounier C. et al. Expression of heat-shock proteins is associated with major adverse prognostic factors in acute myeloid leukemia. Leuk. Res. 2005; 29: 9: 1049-1058.</mixed-citation></ref><ref id="B57"><label>57.</label><mixed-citation>Topper J.N., Gimbrone M.A. Blood flow and vascular gene expression: fluid shear stress as a modulator of endothelial phenotype. Mol. Med. Today. 1999; 5: 1: 40-46.</mixed-citation></ref><ref id="B58"><label>58.</label><mixed-citation>Tsujimoto H., Ono S., Majima T. et al. Differential toll-like receptor expression after ex vivo lipopolysaccharide exposure in patients with sepsis and following surgical stress. Clin. Immunol. 2006; 119: 2: 180-187.</mixed-citation></ref><ref id="B59"><label>59.</label><mixed-citation>Van der Poll T., Buller H.T., Ten Cate H. et al. Activation of coagulation after administration of tumor necrosis factor to normal subjects. New Engl. J. Med. 1990; 322: 7: 1622-1627.</mixed-citation></ref></ref-list></back></article>
