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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="other" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Journal of Experimental and Clinical Surgery</journal-id><journal-title-group><journal-title xml:lang="en">Journal of Experimental and Clinical Surgery</journal-title><trans-title-group xml:lang="ru"><trans-title>Вестник экспериментальной и клинической хирургии</trans-title></trans-title-group></journal-title-group><issn publication-format="print">2070-478X</issn><issn publication-format="electronic">2409-143X</issn><publisher><publisher-name xml:lang="en">Voronezh State Medical University named after N.N. Burdenko</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">31</article-id><article-id pub-id-type="doi">10.18499/2070-478X-2015-8-4-335-341</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Original articles</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Оригинальные статьи</subject></subj-group><subj-group subj-group-type="article-type"><subject></subject></subj-group></article-categories><title-group><article-title xml:lang="en">Tissue reaction to the implantation of the venous wall of synthetic and biological prosthesis</article-title><trans-title-group xml:lang="ru"><trans-title>Тканевая реакция венозной стенки на имплантацию синтетического и биологического протезов</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name><surname>Суковатых</surname><given-names>Б. С.</given-names></name><bio xml:lang="ru"><p>– д.м.н., проф., зав. кафедрой общей хирургии Курского государственного медицинского университета</p></bio><email>admin@vestnik-surgery.com</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name><surname>Барсуков</surname><given-names>В. С.</given-names></name><bio xml:lang="ru"><p>д.н.м., проф. зав. кафедрой общей патологии и физиологии Орловского государственного университета.</p></bio><email>admin@vestnik-surgery.com</email><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><name><surname>Сидоров</surname><given-names>Д. В.</given-names></name><bio xml:lang="ru"><p>соискатель кафедры общей хирургии Курского государственного </p><p>медицинского университета.</p></bio><email>admin@vestnik-surgery.com</email><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en"></institution></aff><aff><institution xml:lang="ru">Курский государственный медицинский университет, ул. К.Маркса, д.3, Курск, 305041, Российская &#13;
Федерация</institution></aff></aff-alternatives><aff-alternatives id="aff2"><aff><institution xml:lang="en"></institution></aff><aff><institution xml:lang="ru">Орловский государственный университет, Медицинский институт, Российская Федерация</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2015-12-24" publication-format="electronic"><day>24</day><month>12</month><year>2015</year></pub-date><volume>8</volume><issue>4</issue><issue-title xml:lang="ru"/><fpage>335</fpage><lpage>341</lpage><history><date date-type="received" iso-8601-date="2016-04-24"><day>24</day><month>04</month><year>2016</year></date><date date-type="accepted" iso-8601-date="2016-04-24"><day>24</day><month>04</month><year>2016</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2015, Voronezh N.N. Burdenko State Medical University</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2015, ФГБОУ ВО ВГМУ им. Н.Н. Бурденко Минздрава России</copyright-statement><copyright-year>2015</copyright-year><copyright-holder xml:lang="en">Voronezh N.N. Burdenko State Medical University</copyright-holder><copyright-holder xml:lang="ru">ФГБОУ ВО ВГМУ им. Н.Н. Бурденко Минздрава России</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://vestnik-surgery.com/journal/about/editorialPolicies</ali:license_ref></license></permissions><self-uri xlink:href="https://vestnik-surgery.com/journal/article/view/31">https://vestnik-surgery.com/journal/article/view/31</self-uri><abstract xml:lang="en"><p>Relevance</p><p>Problem of choosing graft for shunting still remains in vascular surgery.</p><p>The purpose of the study</p><p>To compare tissue reaction of an vein wall to implantation of synthetic and biological endoprostheses.</p><p>Materials and methods</p><p>The analysis of the pilot study carried out on 30 rabbits, divided into two treatment groups of 15 animals</p><p>each. In the first group in the wall of the inferior vena cava implanted synthetic polytetrafluoroethylene prosthesis, the second -</p><p>a biological prosthesis of the internal thoracic arteries bull. Lots of inferior vena cava in a place with an implanted prosthesis</p><p>subjected to histological examination on the 14th, 21th and 30th day after surgery. The drugs were studied by light microscopy after</p><p>staining with hematoxylin-eosin. Morphometric study was carried out, which consists in a certain proportion of the cell structure of</p><p>the connective tissue.</p><p>Results and their discussion</p><p>The inflammatory reaction in the vein wall synthetic prosthesis on the 14th day of 1.14 times on day</p><p>21 to 1.53 times, and on the 30th day of 1.52 is less pronounced than the implantation of a biological prosthesis. The response to a</p><p>biological graft vein wall at day 14 and later on the 30th day and is expressed very strongly represented as a significant inflammatory</p><p>changes with granulomatosis and immunomorphological shear to form the bor</p><p>der with graft lymphoid follicles.</p><p>Conclusion</p><p>When femoropopliteal bypass slot below the knee, in the absence of adequate autologous vein diameter</p><p>should be used combined with a synthetic PTFE prosthesis autovenous inserted into the distal anastomosis.</p><p>Keywords</p><p>tissue reaction, vein, polytetrafluoroethylene prosthesis, biological prosthesis of internal thoracic arteries</p><p>bull.</p></abstract><trans-abstract xml:lang="ru"><p/><p>Актуальность</p><p>До настоящего времени в сосудистой хирургии сохраняется проблема выбора трансплантата для шунти-</p><p>рования.</p><p>Цель исследования</p><p>Сравнить тканевую реакцию венозной стенки на имплантацию синтетического и биологического про-</p><p>тезов.</p><p>Материалы и методы</p><p>Проведен анализ экспериментального исследования, выполненного на 30 кроликах, разделенных на</p><p>две опытные группы по 15 особей в каждой. В первой группе в стенку нижней полой вены имплантировался синтетический</p><p>политетрафторэтиленовый протез, во второй – биологический протез из внутренних грудных артерий быка. Участки</p><p>нижней полой вены в месте с имплантированным протезом подвергались гистологическому исследованию на 14, 21 и 30-е</p><p>сутки после операции. Препараты изучались при световой микроскопии после окраски гематоксилин-эозином. Проводи-</p><p>лось морфометрическое исследование, заключающееся в определении количественного соотношения клеточного состава</p><p>соединительной ткани.</p><p>Результаты и их обсуждение</p><p>Воспалительная реакция венозной стенки на синтетический протез на 14-е сутки в 1,14</p><p>раза, на 21-е сутки – в 1,53 раза, а на 30-е сутки – в 1,52 менее выражена, чем на имплантацию биологического протеза.</p><p>Реакция на биологический трансплантат стенки вены на 14-е сутки и, в последующем, на 30-е сутки выражена очень силь-</p><p>но и представлена как значительными воспалительными изменениями с гранулематозом, так и иммуноморфологическими</p><p>сдвигами с образованием на границе с трансплантатом лимфоидных фолликулов.</p><p>Заключение</p><p>При бедренно-подколенном шунтировании ниже щели коленного сустава при отсутствии адекватной по диа-</p><p>метру аутовены следует применять комбинированный синтетический политетрафторэтиленовый протез с аутовеноз-</p>ной вставкой в области дистального анастомоза</trans-abstract><kwd-group xml:lang="en"><kwd>tissue reaction</kwd><kwd>vein</kwd><kwd>polytetrafluoroethylene prosthesis</kwd><kwd>biological prosthesis of internal thoracic arteries bull.</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>тканевая реакция</kwd><kwd>вена</kwd><kwd>политетрафторэтиленовый протез</kwd><kwd>, биологический протез из внутренних грудных артерий быка.</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>1.</mixed-citation></ref><ref id="B2"><label>2.</label><mixed-citation>Barbarash L.S., Ivanov S.V., Zhuravleva I.Yu., Anufriev</mixed-citation></ref><ref id="B3"><label>3.</label><mixed-citation>A.I., Kazachek Ya.V., Kudriavtzeva Yu.A.,Zinetz M.G. 12</mixed-citation></ref><ref id="B4"><label>4.</label><mixed-citation>letniy opyt ispol'zovaniya bioprotezov dlya zameshcheniya</mixed-citation></ref><ref id="B5"><label>5.</label><mixed-citation>infraingvinal'nykh arteriy. 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