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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="other" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Journal of Experimental and Clinical Surgery</journal-id><journal-title-group><journal-title xml:lang="en">Journal of Experimental and Clinical Surgery</journal-title><trans-title-group xml:lang="ru"><trans-title>Вестник экспериментальной и клинической хирургии</trans-title></trans-title-group></journal-title-group><issn publication-format="print">2070-478X</issn><issn publication-format="electronic">2409-143X</issn><publisher><publisher-name xml:lang="en">Voronezh State Medical University named after N.N. Burdenko</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">430</article-id><article-id pub-id-type="doi">10.18499/2070-478X-2010-3-3-227-229</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Original articles</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Оригинальные статьи</subject></subj-group><subj-group subj-group-type="article-type"><subject>Unknown</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Immunotherapy in complex treatment of non-clostridial anaerobic phlegmons of the facial and neck</article-title><trans-title-group xml:lang="ru"><trans-title>Иммунотерапия в комплексном лечении больных с неклостридиальными анаэробными инфекциями лица и шеи</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name><surname>Губин</surname><given-names>М.А.</given-names></name><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>doctor of medical Sciences, Professor, head of dentistry Department of IPMO Voronezh state medical Academy named. N. N. Burdenko, honored doctor of the Russian Federation</p></bio><bio xml:lang="ru"><p>доктор медицинских наук, профессор, заведующий кафедрой стоматологии ИПМО Воронежской государственной медицинской академии им. Н.Н.Бурденко, заслуженный врач Российской Федерации</p></bio><email>author@vestnik-surgery.com</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name><surname>Оганесян</surname><given-names>А.А.</given-names></name><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>the candidate of medical Sciences, doctor of oral and maxillofacial surgery, senior lecturer in the Department of stomatology of the medical faculty of the Belgorod stateUniversity</p></bio><bio xml:lang="ru"><p>кандидат медицинских наук, врач челюстно-лицевой хирург, старший преподаватель кафедры стоматологии медицинского факультета Белгородского государственного университета</p></bio><email>author@vestnik-surgery.com</email><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><name><surname>Куликовский</surname><given-names>В.Ф.</given-names></name><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>doctor of medical Sciences, Professor, chief doctor of the Belgorod regional clinical hospital svyatitelya Ioasafa</p></bio><bio xml:lang="ru"><p>доктор медицинских наук, профессор, главный врач Белгородской областной клинической больницы святителя Иоасафа</p></bio><email>author@vestnik-surgery.com</email><xref ref-type="aff" rid="aff3"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Voronezh state medical Academy named. N. N. Burdenko</institution></aff><aff><institution xml:lang="ru">Воронежская государственная медицинская академия им. Н.Н.Бурденко</institution></aff></aff-alternatives><aff-alternatives id="aff2"><aff><institution xml:lang="en">Belgorod state University</institution></aff><aff><institution xml:lang="ru">Белгородский государственный университет</institution></aff></aff-alternatives><aff-alternatives id="aff3"><aff><institution xml:lang="en">Belgorod regional clinical hospital svyatitelya Ioasafa</institution></aff><aff><institution xml:lang="ru">Белгородская областная клиническая больница святителя Иоасафа</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2010-09-24" publication-format="electronic"><day>24</day><month>09</month><year>2010</year></pub-date><volume>3</volume><issue>3</issue><issue-title xml:lang="ru"/><fpage>227</fpage><lpage>229</lpage><history><date date-type="received" iso-8601-date="2016-05-01"><day>01</day><month>05</month><year>2016</year></date><date date-type="accepted" iso-8601-date="2016-05-01"><day>01</day><month>05</month><year>2016</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2010, Voronezh N.N. Burdenko State Medical University</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2010, ФГБОУ ВО ВГМУ им. Н.Н. Бурденко Минздрава России</copyright-statement><copyright-year>2010</copyright-year><copyright-holder xml:lang="en">Voronezh N.N. Burdenko State Medical University</copyright-holder><copyright-holder xml:lang="ru">ФГБОУ ВО ВГМУ им. Н.Н. Бурденко Минздрава России</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://vestnik-surgery.com/journal/about/editorialPolicies</ali:license_ref></license></permissions><self-uri xlink:href="https://vestnik-surgery.com/journal/article/view/430">https://vestnik-surgery.com/journal/article/view/430</self-uri><abstract xml:lang="en"><p>The results of treatment of 118 patients with confirmed diagnosis o of nonclostridial anaerobic phlegmons of the facial and neck, are analyzed. The most frequent immune disorders in septic patients are: decrease in lymphocyte count, both T (54%) and В (39,1%) populations, decrease of T-helpers and T-suppressors (57,6%) count and phagocytic coefficient (45,4%). Standard immunoglobulins were used in the treatment: «Intraglobin» and «Pentaglobin» (Biotest, Germany). Analyze of the control immunogramms showed the reliable improvement of immune indices and normalization of T-cell counts.</p></abstract><trans-abstract xml:lang="ru"><p>Проведен анализ результатов лечения 118 больных с неклостридиальными анаэробными флегмонами лица и шеи, подтвержденными клинико лабораторными данными. Наиболее значимыми иммунными нарушениями являются снижение количества лимфоцитов, их Т (54%) и В (39,1%) популяций, уменьшение количества вспомогательных и супрессорных Т-клеток (57,6%), индекса фагоцитоза (45,4%). В комплексном лечении использовали стандартные иммуноглобулины: интраглобин и пентаглобин фирмы «Биотест» (Германия). При анализе контрольных иммунограмм отмечены достоверные изменения, свидетельствующие об улучшении и даже нормализации некоторых специфических параметров, в частности, нормализация показателей Т лимфоцитов.</p></trans-abstract><kwd-group xml:lang="en"><kwd>anaerobic phlegmon</kwd><kwd>immune disorders</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>анаэробная флегмона</kwd><kwd>иммунные нарушения</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>1. Ostanin A. A., On Leplina.Yu., Tikhonova M. A., etc. [Surgical Sepsis. Part 1. Immunological markers of systemic inflammation. Bulletin of surgery ]2002; 161:3: 101-107.</mixed-citation></ref><ref id="B2"><label>2.</label><mixed-citation>2. Ostanin A. A., On Leplina. Yu., Tikhonova M. A., etc. [Cytokineproducing mechanisms of systemic immunosuppression in patients with purulent surgical pathology. 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