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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="other" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Journal of Experimental and Clinical Surgery</journal-id><journal-title-group><journal-title xml:lang="en">Journal of Experimental and Clinical Surgery</journal-title><trans-title-group xml:lang="ru"><trans-title>Вестник экспериментальной и клинической хирургии</trans-title></trans-title-group></journal-title-group><issn publication-format="print">2070-478X</issn><issn publication-format="electronic">2409-143X</issn><publisher><publisher-name xml:lang="en">Voronezh State Medical University named after N.N. Burdenko</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">530</article-id><article-id pub-id-type="doi">10.18499/2070-478X-2010-3-3-214-217</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Original articles</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Оригинальные статьи</subject></subj-group><subj-group subj-group-type="article-type"><subject>Unknown</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Remote preconditioning influence on ischemic tissues survival potential</article-title><trans-title-group xml:lang="ru"><trans-title>Влияние дистантного прекондиционировния на выживаемость ишемизированных тканей</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name><surname>Колесник</surname><given-names>И.М.</given-names></name><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>postgraduate student of the Department of pharmacology, Kursk state medical University</p></bio><bio xml:lang="ru"><p>заочный аспирант кафедры фармакологии Курского государственного медицинского университета</p></bio><email>author@vestnik-surgery.com</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name><surname>Покровский</surname><given-names>M.В.</given-names></name><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>doctor of medical Sciences, Professor, head of the pharmacology Department of the Kursk state medical University, academician of RANS</p></bio><bio xml:lang="ru"><p>доктор медицинских наук, профессор, заведующий кафедройфармакологии Курского государственного медицинского университета, академик РАЕН</p></bio><email>author@vestnik-surgery.com</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name><surname>Лазаренко</surname><given-names>В.А,</given-names></name><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>doctor of medical Sciences, Professor, head of chair of surgical diseases of FPE, the rector of the Kursk state medical University, corresponding member of RANS, academician of MANEB, AMT, honored doctor of the Russian Federation</p></bio><bio xml:lang="ru"><p>доктор медицинских наук, профессор, заведующий кафедройхирургических болезней ФПО, ректор Курского государственного медицинского университета, член-корреспондент РАЕН, академик МАНЭБ, АМТ, заслуженный врач Российской Федерации</p></bio><email>author@vestnik-surgery.com</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name><surname>Гудырев</surname><given-names>O.С.</given-names></name><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>PhD, doctoral candidate of the Department of clinical pharmacology of Kursk state medical University</p></bio><bio xml:lang="ru"><p>к.м.н., докторант кафедры клинической фармакологии Курского государственного медицинского университета</p></bio><email>author@vestnik-surgery.com</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name><surname>Гуреев</surname><given-names>В.В.</given-names></name><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>the candidate of medical Sciences, senior researcher of the Institute of Environmental medicine of Kursk state medical University</p></bio><bio xml:lang="ru"><p>кандидат медицинских наук, старший научный сотрудник НИИ Экологической медицины Курского государственного медицинского университета</p></bio><email>author@vestnik-surgery.com</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name><surname>Даниленко</surname><given-names>Л.М.</given-names></name><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>candidate of pharmacological Sciences, graduate school of pharmacology, Kursk state medical University</p></bio><bio xml:lang="ru"><p>кандидат фармакологических наук, соискатель кафедры фармакологии Курского государственного медицинскогоуниверситета</p></bio><email>author@vestnik-surgery.com</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name><surname>Королев</surname><given-names>A.E.</given-names></name><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>postgraduate student of the Department of pharmacology, Kursk state medical University</p></bio><bio xml:lang="ru"><p>заочный аспирант кафедры фармакологии Курского государственного медицинского университета</p></bio><email>author@vestnik-surgery.com</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name><surname>Нариков</surname><given-names>Р.А.</given-names></name><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>postgraduate student of the Department of pharmacology, Kursk state medical University</p></bio><bio xml:lang="ru"><p>заочный аспирант кафедры фармакологии Курского государственного медицинского университета</p></bio><email>author@vestnik-surgery.com</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name><surname>Желудков</surname><given-names>И.С.</given-names></name><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>postgraduate student of the Department of pharmacology, Kursk state medical University</p></bio><bio xml:lang="ru"><p>заочный аспирант кафедры фармакологии Курского государственного медицинского университета</p></bio><email>author@vestnik-surgery.com</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name><surname>Лопатин</surname><given-names>Д.В.</given-names></name><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>postgraduate student of the Department of pharmacology, Kursk state medical University</p></bio><bio xml:lang="ru"><p>заочный аспирант кафедры фармакологии Курского государственного медицинского университета</p></bio><email>author@vestnik-surgery.com</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name><surname>Егорова</surname><given-names>E.O.</given-names></name><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>postgraduate student of the Department of pharmacology, Kursk state medical University</p></bio><bio xml:lang="ru"><p>заочный аспирант кафедры фармакологии Курского государственного медицинского университета</p></bio><email>author@vestnik-surgery.com</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name><surname>Алехин</surname><given-names>С.А.</given-names></name><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>the candidate of medical Sciences, assistant of the surgical diseases chair №2 of Kursk state medical University</p></bio><bio xml:lang="ru"><p>кандидат медицинских наук, ассистент кафедры хирургических болезней №2 Курского государственного медицинского университета</p></bio><email>author@vestnik-surgery.com</email><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Kursk state medical University</institution></aff><aff><institution xml:lang="ru">Курский государственный медицинский университет</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2010-09-24" publication-format="electronic"><day>24</day><month>09</month><year>2010</year></pub-date><volume>3</volume><issue>3</issue><issue-title xml:lang="ru"/><fpage>214</fpage><lpage>217</lpage><history><date date-type="received" iso-8601-date="2016-05-04"><day>04</day><month>05</month><year>2016</year></date><date date-type="accepted" iso-8601-date="2016-05-04"><day>04</day><month>05</month><year>2016</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2010, Voronezh N.N. Burdenko State Medical University</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2010, ФГБОУ ВО ВГМУ им. Н.Н. Бурденко Минздрава России</copyright-statement><copyright-year>2010</copyright-year><copyright-holder xml:lang="en">Voronezh N.N. Burdenko State Medical University</copyright-holder><copyright-holder xml:lang="ru">ФГБОУ ВО ВГМУ им. Н.Н. Бурденко Минздрава России</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://vestnik-surgery.com/journal/about/editorialPolicies</ali:license_ref></license></permissions><self-uri xlink:href="https://vestnik-surgery.com/journal/article/view/530">https://vestnik-surgery.com/journal/article/view/530</self-uri><abstract xml:lang="en"><p>The investigation of remote preconditioning influence on isolated skin pedicle flap was taken. Also the role of К+ATP-channels was detected in the realization of positive remote preconditioning effect. Application of remote preconditioning allowed to half again as raise the survival potential of skin flap in comparison with control group. Preconditioning positive effect cancellation in introducing of К+ATP-channels blocker glibenclamid to animals witness that ATP-dependent К+-channels are important and necessary part in the realization of preconditioning positive effect.</p></abstract><trans-abstract xml:lang="ru"><p>Проведено исследование влияния дистантного прекондиционировния на выживаемость изолированного кожного лоскута на ножке, а так же определена роль К+АТФ-каналов в реализации положительного эффекта дистантногопрекондиционировния. Применение дистантного прекондиционировния позволило добиться увеличения выживаемости кожного лоскута по сравнению с контрольной группой в 1,5 раза. Отмена положительного эффекта прекондиционировния при введении животным третьей опытной группы блокатора К+АТФ-каналов глибенкламида свидетельствует о том, что АТФ-зависимые К+-каналы являются значимым и необходимым звеном в реализации положительного эффекта прекондиционировния.</p></trans-abstract><kwd-group xml:lang="en"><kwd>remote preconditioning</kwd><kwd>ischemia</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>дистантное прекондиционирование</kwd><kwd>ишемия</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>1. Avtandilov G. G.[ Fundamentals of pathoanatomical practice.] M.: 1994, cum laude; 512.</mixed-citation></ref><ref id="B2"><label>2.</label><mixed-citation>2. Artyushkova E. B.,. D Pashkov[.In, the knotty B. S. pharmacological correction of chronic limb ischemia in experiment. 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