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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="other" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Journal of Experimental and Clinical Surgery</journal-id><journal-title-group><journal-title xml:lang="en">Journal of Experimental and Clinical Surgery</journal-title><trans-title-group xml:lang="ru"><trans-title>Вестник экспериментальной и клинической хирургии</trans-title></trans-title-group></journal-title-group><issn publication-format="print">2070-478X</issn><issn publication-format="electronic">2409-143X</issn><publisher><publisher-name xml:lang="en">Voronezh State Medical University named after N.N. Burdenko</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">591</article-id><article-id pub-id-type="doi">10.18499/2070-478X-2011-4-3-532-537</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Original articles</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Оригинальные статьи</subject></subj-group><subj-group subj-group-type="article-type"><subject>Unknown</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Criteria for the diagnosis of intrauterine infection newborn</article-title><trans-title-group xml:lang="ru"><trans-title>Критерии диагностики внутриутробного инфицирования новорожденного</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name><surname>Руселкин</surname><given-names>E.A.</given-names></name><bio xml:lang="ru"><p>детский хирург выс-шей категории, врач ординатор Детской городскойклинической больницы №1 г. Новосибирска, заоч-ный аспирант кафедры детской хирургии Новоси-бирского государственного медицинского универ-ситета</p></bio><email>vsh33@yandex.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name><surname>Прутовых</surname><given-names>Н.Н.</given-names></name><bio xml:lang="ru"><p>д.м.н., профессордетской хирургии Новосибирского государствен-ного медицинского университета, хирург высшейкатегории, заслуженный врач РФ</p></bio><email>vsh33@yandex.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name><surname>Доброскокова</surname><given-names>Н.Ф.</given-names></name><bio xml:lang="ru"><p>заведующаяпатологоанатомическим отделением Детской го-родской клинической больницы №1 г. Новосибир-ска</p></bio><email>vsh33@yandex.ru</email><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en"></institution></aff><aff><institution xml:lang="ru">Новосибирский государственный медицинский университет Детская городская клиническая больница №1, Новосибирск</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2011-09-24" publication-format="electronic"><day>24</day><month>09</month><year>2011</year></pub-date><volume>4</volume><issue>3</issue><issue-title xml:lang="ru"/><fpage>532</fpage><lpage>537</lpage><history><date date-type="received" iso-8601-date="2016-05-08"><day>08</day><month>05</month><year>2016</year></date><date date-type="accepted" iso-8601-date="2016-05-08"><day>08</day><month>05</month><year>2016</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2011, Voronezh N.N. Burdenko State Medical University</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2011, ФГБОУ ВО ВГМУ им. Н.Н. Бурденко Минздрава России</copyright-statement><copyright-year>2011</copyright-year><copyright-holder xml:lang="en">Voronezh N.N. Burdenko State Medical University</copyright-holder><copyright-holder xml:lang="ru">ФГБОУ ВО ВГМУ им. Н.Н. Бурденко Минздрава России</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://vestnik-surgery.com/journal/about/editorialPolicies</ali:license_ref></license></permissions><self-uri xlink:href="https://vestnik-surgery.com/journal/article/view/591">https://vestnik-surgery.com/journal/article/view/591</self-uri><abstract xml:lang="en"><p>Authors proved the role of intrauterine infection in the development of disease of the newborn agents, which penetrate tothe fetus from an infected mother's birth canal. Confi rmed that the risk of fetal infection and the possibility of infection inthe form of the disease in newborns due to the type of pathogen, the degree of its virulence, the massiveness of the infectionpathways of microorganisms (usually ascending and hematogenous), premorbid background of the mother and the natureof complications during pregnancy and childbirth. The diagnostic value of markers of intrauterine infection, developedcriteria for the diagnosis of intrauterine infection, with subsequent formation of groups at risk of neonatal special diagnosticsignifi cance given to the histological examination of placenta, fetal membranes, umbilical cord. Also noted the role ofimmunoglobulins IgM, IgG, IgA, and acute phase proteins - fi brinogen and CRP are markers of infl ammation and damage.</p></abstract><trans-abstract xml:lang="ru"><p>Авторами доказана роль внутриутробного инфицирования новорожденного возбудителями, проникающими к плодуот инфицированной матери по родовым путям. Подтверждено, что риск инфицированности плода и возможностьреализации инфекции в виде болезни у новорожденных обусловлены видом возбудителя, степенью его вирулентно-сти, массивностью инфицирования, путями проникновения микроорганизмов (чаще восходящий и гематогенный),преморбидным фоном матери и характером осложнений течения беременности и родов. Показана диагностическаязначимость маркеров внутриутробной инфекции, выработаны критерии диагностики внутриутробного инфици-рования, с последующим формированием групп риска среди новорожденных Особая диагностическая значимостьотдана гистологическому исследованию плаценты, плодным оболочкам, пуповине. Кроме того, отмечена роль им-муноглобулинов класса IgM, IgG, IgA, а также острофазовых белков - фибриногена и СРБ, являющихся маркерамивоспаления и повреждения.</p></trans-abstract><kwd-group xml:lang="en"><kwd>newborns</kwd><kwd>intrauterine infection</kwd><kwd>diagnosis</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>новорожденные</kwd><kwd>внутриутробное инфицирование</kwd><kwd>диагностика</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>1. Anokhin V.A. Sovremennye printsipy kliniko–labora-</mixed-citation></ref><ref id="B2"><label>2.</label><mixed-citation>tornoi diagnostiki gerpeticheskikh infektsii. Kazan-</mixed-citation></ref><ref id="B3"><label>3.</label><mixed-citation>skii meditsinskii zhurnal 1999; 80: 2: 127–129.</mixed-citation></ref><ref id="B4"><label>4.</label><mixed-citation>2. Drozdova S.G., Dolgikh T.I., Beloskodtseva L.N. Vnutri-</mixed-citation></ref><ref id="B5"><label>5.</label><mixed-citation>utrobnye infektsii v strukture zabolevaemosti i</mixed-citation></ref><ref id="B6"><label>6.</label><mixed-citation>smertnosti novorozhdennykh gorodskogo klinicheskogo</mixed-citation></ref><ref id="B7"><label>7.</label><mixed-citation>perinatal'nogo tsentra. Detskie infektsii: Nauchno –</mixed-citation></ref><ref id="B8"><label>8.</label><mixed-citation>prakticheskii zhurnal. Assotsiatsii pediatrov – infek-</mixed-citation></ref><ref id="B9"><label>9.</label><mixed-citation>tsionistov 2004; 1: 60–62.</mixed-citation></ref><ref id="B10"><label>10.</label><mixed-citation>3. Kapranova E.I., Belousova N.A., Mel'nikova E.V., Ga-</mixed-citation></ref><ref id="B11"><label>11.</label><mixed-citation>zovskaia L.A., Sokolova T.A. Klinicheskoe techenie i dia-</mixed-citation></ref><ref id="B12"><label>12.</label><mixed-citation>gnostika vnutriutrobnykh infektsii u novorozhden-</mixed-citation></ref><ref id="B13"><label>13.</label><mixed-citation>nykh. Epidemiologiia i infektsionnye bolezni 1997; 1:</mixed-citation></ref><ref id="B14"><label>14.</label><mixed-citation>27-30.</mixed-citation></ref><ref id="B15"><label>15.</label><mixed-citation>4. Kuznetsov M.I., Belkovskaia M.E., Babaeva O.I. Ekhogra-</mixed-citation></ref><ref id="B16"><label>16.</label><mixed-citation>ficheskaia kartina «infitsirovannoi» platsenty – nai-</mixed-citation></ref><ref id="B17"><label>17.</label><mixed-citation>bolee veroiatnye priznaki. Ul'trazvuk. diagn. akush.</mixed-citation></ref><ref id="B18"><label>18.</label><mixed-citation>ginek. pediatr. 2000; 8: 2: 284–288.</mixed-citation></ref><ref id="B19"><label>19.</label><mixed-citation>5. Samsygina G. A. Diskussionnye voprosy klassifika-</mixed-citation></ref><ref id="B20"><label>20.</label><mixed-citation>tsii, diagnostiki i lecheniia sepsisa v pediatrii. Pe-</mixed-citation></ref><ref id="B21"><label>21.</label><mixed-citation>diatriia 2003; 3: 18-25.</mixed-citation></ref><ref id="B22"><label>22.</label><mixed-citation>6. Sidorova I.S., Chernienko I.N. Osobennosti techeniia i</mixed-citation></ref><ref id="B23"><label>23.</label><mixed-citation>vedeniia beremennosti pri vnutriutrobnom infitsi-</mixed-citation></ref><ref id="B24"><label>24.</label><mixed-citation>rovanii ploda. Rossiiskii vestnik perinatologii i</mixed-citation></ref><ref id="B25"><label>25.</label><mixed-citation>pediatrii 1998; 4: 13 – 17.</mixed-citation></ref><ref id="B26"><label>26.</label><mixed-citation>7. Tabolin V.A., Volodin N.N., Degtiareva M.V., Degtiarev</mixed-citation></ref><ref id="B27"><label>27.</label><mixed-citation>D.N., Bakhtikian K.K. Aktual'nye voprosy perinatal'-</mixed-citation></ref><ref id="B28"><label>28.</label><mixed-citation>noi immunologii. Intern. J. Immunorehabilitation 1997;</mixed-citation></ref><ref id="B29"><label>29.</label><mixed-citation>6: 112-122.</mixed-citation></ref><ref id="B30"><label>30.</label><mixed-citation>8. Tsinzerling V.A., Mel'nikova V.F. Perinatal'nye</mixed-citation></ref><ref id="B31"><label>31.</label><mixed-citation>infektsii. (Voprosy patogeneza, morfologicheskoi</mixed-citation></ref><ref id="B32"><label>32.</label><mixed-citation>diagnostiki i kliniko – morfologicheskikh sopostav-</mixed-citation></ref><ref id="B33"><label>33.</label><mixed-citation>lenii). Prakticheskoe rukovodstvo. SPb.: Elbi SPb,</mixed-citation></ref><ref id="B34"><label>34.</label><mixed-citation>2002; 38-73.</mixed-citation></ref><ref id="B35"><label>35.</label><mixed-citation>9. Shabaldin A.V., Balianova L.A, Kazakova L.M. Primene-</mixed-citation></ref><ref id="B36"><label>36.</label><mixed-citation>nie polimeraznoi tsepnoi reaktsii v diagnostike vnu-</mixed-citation></ref><ref id="B37"><label>37.</label><mixed-citation>triutrobnykh infektsii u plodov i novorozhdennykh.</mixed-citation></ref><ref id="B38"><label>38.</label><mixed-citation>Pediatriia 2000; 3: 38-41.</mixed-citation></ref><ref id="B39"><label>39.</label><mixed-citation>10. Sharapova O.V. Osnovnye problemy i zadachi razvitiia</mixed-citation></ref><ref id="B40"><label>40.</label><mixed-citation>rossiiskoi pediatrii na sovremennom etape. Rossii-</mixed-citation></ref><ref id="B41"><label>41.</label><mixed-citation>skii vestnik perinatologii i pediatrii 2003; 1: 3-4.</mixed-citation></ref><ref id="B42"><label>42.</label><mixed-citation>11. Corey R.P., Flynn J. Maternal intrauterine herpes simplex</mixed-citation></ref><ref id="B43"><label>43.</label><mixed-citation>virus infection leading to persistent fetal Vasculature R.P.</mixed-citation></ref><ref id="B44"><label>44.</label><mixed-citation>Corey, J.T. Flynn Arch Ophthalmol. 2000; 118: 6: 837-840.</mixed-citation></ref><ref id="B45"><label>45.</label><mixed-citation>12. Gerdts V., Babiuk L. A., van Drunen H., Griebel P. J. Fetal</mixed-citation></ref><ref id="B46"><label>46.</label><mixed-citation>immunization by a DNA vaccine delivered into the oral</mixed-citation></ref><ref id="B47"><label>47.</label><mixed-citation>cavity. Nat. Med. 2000; 6: 8: 929-932.</mixed-citation></ref><ref id="B48"><label>48.</label><mixed-citation>13. Greenough A. Neonatal infections. Curr. Opin. Pediatr.</mixed-citation></ref><ref id="B49"><label>49.</label><mixed-citation>1996; 8: 1: 6-10.</mixed-citation></ref><ref id="B50"><label>50.</label><mixed-citation>14. Leviton A., Paneth N., Reuss M., et al. Maternal infection,</mixed-citation></ref><ref id="B51"><label>51.</label><mixed-citation>fetal infl ammatory response and brain damage in very low</mixed-citation></ref><ref id="B52"><label>52.</label><mixed-citation>birth weight infants. Pediatric Recearch 1999; 45: 5: 49-56.</mixed-citation></ref><ref id="B53"><label>53.</label><mixed-citation>15. Maher C., Haran M., Farrell D. Ureaplasma urealiticum</mixed-citation></ref><ref id="B54"><label>54.</label><mixed-citation>chonoamnionitis. Am J Obstet Gynec 2001; 34: 477- 479 .</mixed-citation></ref><ref id="B55"><label>55.</label><mixed-citation>16. Pratlong F., Boulot, Villena I., Issert E., Tamby.,</mixed-citation></ref><ref id="B56"><label>56.</label><mixed-citation>Cazenave J., Debet J.P. Antenatal diagnosis of congenital</mixed-citation></ref><ref id="B57"><label>57.</label><mixed-citation>toxoplasmosis: evaluation of the biological parameters in a</mixed-citation></ref><ref id="B58"><label>58.</label><mixed-citation>cohort of 286 patients. Br. J. Obstet. Gynaecol.1996; 103:</mixed-citation></ref><ref id="B59"><label>59.</label><mixed-citation>6: 552-557.</mixed-citation></ref></ref-list></back></article>
