Journal of Experimental and Clinical SurgeryJournal of Experimental and Clinical SurgeryВестник экспериментальной и клинической хирургии2070-478X2409-143XVoronezh State Medical University named after N.N. Burdenko6210.18499/2070-478X-2012-5-2-247-252Original articlesОригинальные статьиUnknownCorrection of lipid-transport system at experimental widespread purulent peritonitisКоррекция изменений липид-транспортной системы при экспериментальном распространенном гнойном перитонитеГостищевВ.К.

д.м.н., проф., академик РАМН, Президент Ассоциации общих хирургов Российской Федерации, зав. кафедрой общей хирургии Первого Московского государственного медицинского университета им. И.М.Сеченова, председатель проблемной комиссии «Инфекция в хирургии» Межведомственного научного Совета по хирургии РАМН и Министерства здравоохранения Российской Федерации.

author@vestnik-surgery.comКосинецВ.A.

к.м.н.,  док-торант кафедры общей хирургии Первого Москов-ского государственного медицинского университе-та им. и.М.сеченова; e-mail: vkosinets@yandex.by

author@vestnik-surgery.comПервый Московский государственный медицинский университет им. И.М.Сеченова24062012522472522604201626042016Copyright ©; 2012, ., .Copyright ©; 2012, Гостищев В., Косинец В.2012., .Гостищев В., Косинец В.http://creativecommons.org/licenses/by-nc-nd/4.0https://vestnik-surgery.com/journal/article/view/62

Research is spent on 40 rabbits-males of chinchilla breed. For the first time influence of a preparation of omega-3 fatty acids «Omegaven» on protein-lipid spectrum of blood is studied at an experimental widespread purulent peritonitis. It is established that in the postoperative period «Omegaven» effectively influences on protein-lipid spectrum of blood by prevention of sharp decrease in quantity of proteins, lipoproteins of high density (HDL) and maintenance of triglyceride’s growth. Positive action of the preparation also is connected with percentage decrease of lisophosphatides and level increase of polyglycerophosphatides in phopholipid spectrum of HDL.

Исследование проведено на 40 кроликах-самцах породы шиншилла. Впервые изучено влияние препарата омега-3 жирных кислот «Омегавен» на липидно-белковый спектр сыворотки крови при экспериментальном распространенном гнойном перитоните. Установлено, что в послеоперационном периоде «Омегавен» эффективно влияет на липидно-белковый спектр сыворотки крови путем предотвращения резкого снижения количества белка, липопротеинов высокой плотности (ЛПВП) и роста содержания триглицеридов. Положительное действие препарата также связано со снижением процентного содержания лизофосфатидов и увеличением уровня полиглицерофосфати- дов в фосфолипидном спектре ЛПВП.

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