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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="research-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Journal of Experimental and Clinical Surgery</journal-id><journal-title-group><journal-title xml:lang="en">Journal of Experimental and Clinical Surgery</journal-title><trans-title-group xml:lang="ru"><trans-title>Вестник экспериментальной и клинической хирургии</trans-title></trans-title-group></journal-title-group><issn publication-format="print">2070-478X</issn><issn publication-format="electronic">2409-143X</issn><publisher><publisher-name xml:lang="en">Voronezh State Medical University named after N.N. Burdenko</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">840</article-id><article-id pub-id-type="doi">10.18499/2070-478X-2016-9-1-43-52</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Original articles</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Оригинальные статьи</subject></subj-group><subj-group subj-group-type="article-type"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">The Clinico-Rheological Status of the Soft Tissue Surgical Infection</article-title><trans-title-group xml:lang="ru"><trans-title>Клинико-реологический статус хирургической инфекции мягких тканей</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Larichev</surname><given-names>A. B.</given-names></name><name xml:lang="ru"><surname>Ларичев</surname><given-names>А. Б.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>MD, Professor, head. the Departmentof General surgery, Yaroslavl state medical University</p></bio><bio xml:lang="ru"><p>д.м.н., проф., заведующий кафедройобщей хирургии Ярославского государственногомедицинского университета</p></bio><email>larich-ab@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Muravyov</surname><given-names>A. V.</given-names></name><name xml:lang="ru"><surname>Муравьёв</surname><given-names>А. В.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>MD, Professor, Professor ofDepartment of medical and biological bases of sportsof the Yaroslavl state pedagogical University</p></bio><bio xml:lang="ru"><p>д.биол.н., проф., профессор кафе-дры медико-биологических основ спорта Ярослав-ского государственного педагогического универси-тета</p></bio><email>alexei.47@mail.ru</email><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Komlev</surname><given-names>V. L.</given-names></name><name xml:lang="ru"><surname>Комлев</surname><given-names>В. Л.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>assistant of Department of clinical dentistry 1, Yaroslavl state medical University</p></bio><bio xml:lang="ru"><p>ассистент кафедры клинической сто-матологии N1 Ярославского государственного меди-цинского университета</p></bio><email>kvlvl909@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Chistyakov</surname><given-names>A. L.</given-names></name><name xml:lang="ru"><surname>Чистяков</surname><given-names>А. Л.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>PhD, assistant of Department ofGeneral surgery, Yaroslavl state medical University</p></bio><bio xml:lang="ru"><p>к.м.н., ассистент кафедры общейхирургии Ярославского государственного меди-цинского университета</p></bio><email>chistyakov2006@ya.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Ryabov</surname><given-names>M. M.</given-names></name><name xml:lang="ru"><surname>Рябов</surname><given-names>М. М.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>PhD, assistant of the Department ofGeneral surgery Yaroslavsky state medical University</p></bio><bio xml:lang="ru"><p>к.м.н., ассистент кафедры общей хи-рургии Ярославского государственного медицин-ского университета</p></bio><email>mihail_ryabov@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Dylenok</surname><given-names>A. A.</given-names></name><name xml:lang="ru"><surname>Дыленок</surname><given-names>А. А.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>senior laboratory assistant ofDepartment of Oncology of the Yaroslavl state medicalUniversity</p></bio><bio xml:lang="ru"><p>старший лаборант кафедры онко-логии Ярославского государственного медицинско-го университета</p></bio><email>dylenok-onco@rambler.ru</email><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Yaroslavl State Medical University</institution></aff><aff><institution xml:lang="ru">Ярославский государственный медицинский университет</institution></aff></aff-alternatives><aff-alternatives id="aff2"><aff><institution xml:lang="en">Yaroslavl State Pedagogical University named K.D. Ushinsky</institution></aff><aff><institution xml:lang="ru">Ярославский государственный педагогический университет</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2016-03-23" publication-format="electronic"><day>23</day><month>03</month><year>2016</year></pub-date><volume>9</volume><issue>1</issue><issue-title xml:lang="ru"/><fpage>43</fpage><lpage>52</lpage><history><date date-type="received" iso-8601-date="2016-11-15"><day>15</day><month>11</month><year>2016</year></date><date date-type="accepted" iso-8601-date="2016-11-16"><day>16</day><month>11</month><year>2016</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2016, Larichev A.B., Muravyov A.V., Komlev V.L., Chistyakov A.L., Ryabov M.M., Dylenok A.A.</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2016, Ларичев А.Б., Муравьёв А.В., Комлев В.Л., Чистяков А.Л., Рябов М.М., Дыленок А.А.</copyright-statement><copyright-year>2016</copyright-year><copyright-holder xml:lang="en">Larichev A.B., Muravyov A.V., Komlev V.L., Chistyakov A.L., Ryabov M.M., Dylenok A.A.</copyright-holder><copyright-holder xml:lang="ru">Ларичев А.Б., Муравьёв А.В., Комлев В.Л., Чистяков А.Л., Рябов М.М., Дыленок А.А.</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">http://creativecommons.org/licenses/by-nc-nd/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://vestnik-surgery.com/journal/article/view/840">https://vestnik-surgery.com/journal/article/view/840</self-uri><abstract xml:lang="en"><p>Relevance The problem of treatment of the soft tissue infection is connected with features of the hemorheological status. Itsmulticomponent assessment will allow proving the pathogenetic importance of the haemo corrective means allowing to make apositive impact on effectiveness of surgical treatment of patients with such pathology.The purpose of the study Is to represent a comparative assessment of the clinico-rheological status at treatment of the soft tissuesurgical infection of the anterior abdominal wall and maxillofacial area.Materials and methods Results of treatment of 73 patients with pyoinflammatory pathology of the anterior abdominal wall (36cases) and on the face and neck (37 cases) are analyzed. To assess the wound process clinico-laboratory indicators were used, andalso there were used the hemorheological profile including viscosity of blood at high and low speeds of shift, viscosity of plasma,corpuscular volume, viscosity of coarse dispersion and the indicator of aggregation of erythrocytes, indexes of their lengthening andrigidity, and also the index of oxygen transport efficiency.</p><p>Results and discussion In the setting of the purulent process in the anterior abdominal wall significant changes of thehaemorheological profile concern strengthening of erythrocyte aggregation, the expressed increase of blood viscosity at rather lowspeeds of the shift, reduction in deformability of red blood counts and the index of oxygen transport efficiency in blood. Within 7days the tendency of stabilizing indicators is observed, however, macrorheological characteristics are not normal, and it testifiesthat there are suppurative changes of the homeostasis. In cases of septic diseases in the face and neck, qualitative and quantitativeindicators of the estimated criteria are comparable to parameters of the rheological status of patients of the previous group. Thetraditional complex of remedial actions is followed with the greatest correction by the indicator of erythrocyte aggregation. Itconcerns, in a less degree, the blood viscosity at high and low speeds of the shift, and also viscosity of erythrocyte coarse dispersionand the index of oxygen transport efficiency in blood (p&gt;0,05).Summary The surgical infection of soft tissues is characterized by changes of all indicators of the haemorheological profile. Inthe course of treatment they are corrected without achieving the norm and that increases the risk of the development of localcomplications. When there is a septic disease of the cell areas of the face and neck, rheological shifts have smaller expressiveness,and their correction has a prolonged character.Key words nfection of soft tissues, haemorheology, surgical service.</p></abstract><trans-abstract xml:lang="ru"><p>Актуальность Проблема инфекции мягких тканей связана с особенностями гемореологического статуса. Знание измене-ний ключевых его параметров позволяет расширить патогенетические возможности хирургического лечения больных сподобной патологией.Цель исследования Представить сравнительную оценку клинико-реологического статуса при лечении хирургической ин-фекции мягких тканей передней брюшной стенки и челюстно-лицевой области.Материалы и методы Анализированы результаты лечения 73 пациентов с гнойной раной передней брюшной стенки (36наблюдений) и с флегмонозным воспалением клетчаточных пространств в области лица и шеи (37 наблюдений). Для оцен-ки раневого процесса использовали клинико-лабораторные показатели, а также гемореологический профиль, включающийвязкость крови при высоких и низких скоростях сдвига, вязкость плазмы, гематокритное число, вязкость суспензии ипоказатель агрегации эритроцитов, индексы их удлинения и ригидности, а также индекс эффективности транспортакислорода.Результаты и их обсуждение На фоне гнойного процесса в области передней брюшной стенки значимые изменения ге-мореологического профиля касаются усиления агрегации эритроцитов, выраженного прироста вязкости крови при от-носительно низких скоростях сдвига, уменьшения деформируемости красных кровяных телец и индекса эффективноститранспорта кислорода кровью. В течение 7 дней лечения наблюдается тенденция к стабилизации показателей, однако ма-крореологические характеристики не достигают нормы, что свидетельствует о сохранении воспалительных измененийв гомеостазе. При гнойных заболеваниях в области лица и шеи качественное и количественное выражение оцениваемыхкритериев сопоставимы с параметрами реологического статуса больных предыдущей группы. Традиционный комплекс ле-чебных мер сопровождается наибольшей коррекцией со стороны показателя агрегации эритроцитов. В меньшей степениэто касается вязкости крови при высоких и низких скоростях сдвига, а также вязкости суспензии эритроцитов и индексаэффективности транспорта кислорода кровью (p&gt;0,05).Заключение Хирургическая инфекция мягких тканей характеризуется изменениями всех показателей гемореологическогопрофиля. В процессе лечения происходит их коррекция без достижения нормы, что повышает риск развития местныхосложнений. При гнойном поражении клетчаточных пространств лица и шеи реологические сдвиги имеют меньшую вы-раженность, и их коррекция носит пролонгированный характер.Ключевые слова инфекция мягких тканей, гемореология, хирургическое лечение.</p></trans-abstract><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>1. Bitkova, E. E., Ilyashenko K. K., Khvatov V. B., Simonova A. Y. Vozrastnye izmeneniya gemoreologicheskogo statusa. Zhurnal im. N.V. Sklifosovskogo Neotlozhnaya meditsinskaya pomoshch'. [Age-related changes of haemorheological status. Journal named after N. V. Sklifosovsky Emergency medical aid] 2015; 4: 27-29 (in Russ.).</mixed-citation></ref><ref id="B2"><label>2.</label><mixed-citation>2. Kozin D. V., Rodina O. P., Moiseeva I. Ya. Farmako-epidemiologicheskiy analiz gnoynovospalitel'nykh zabolevaniy chelyustno-litsevoy oblasti u zhiteley Penzenskoy oblasti. Izvestiya vysshikh meditsinskikh zavedeniy. [Pharmacoepidemiological analysis of purulent-inflammatory diseases of maxillofacial area of the residents of the Penza region. News of higher medical institutions]. 2010; 1: 99-105 (in Russ.).</mixed-citation></ref><ref id="B3"><label>3.</label><mixed-citation>3. Larichev A. B., Shishlo V. K., Lisowski, A. V. etc. Profilaktika ranevoy infektsii i morfologicheskie aspekty zazhivleniya asepticheskoy rany. Vestnik eksperimental'noy i klinicheskoy khirurgii [Prevention of wound infection and morphological aspects of the healing of aseptic wounds. Journal of experimental and clinical surgery] 2011; 4: 728-733 (in Russ.).</mixed-citation></ref><ref id="B4"><label>4.</label><mixed-citation>4. Larichev A. B., Shishlo V. K., Lisowski, A. V., Ryabov M. M. Osobennosti reparativnoy regeneratsii pri zazhivlenii asepticheskoy rany pri razlichnykh sposobakh podgotovki operatsionnogo polya v usloviyakh eksperimenta. Morfologiya [Features of reparative regeneration in the healing of aseptic wounds using different ways of preparation of the surgical field in the experiment. Morphology] 2014; 6: 97-101 (in Russ.).</mixed-citation></ref><ref id="B5"><label>5.</label><mixed-citation>5. Muravyov A. V., Muravyov A. A. Vne i vnutrikletochnye mekhanizmy izmeneniya agregatsii eritrotsitov. Fiziologiya cheloveka. [Intra- and intercellular mechanisms of changes of the aggregation of erythrocytes. Human physiology] 2005; 31 (4): 108-112 (in Russ.).</mixed-citation></ref><ref id="B6"><label>6.</label><mixed-citation>6. Muravyov A. V., Tikhomirova I. A., Bulaeva S. V., etc. Issledovanie roli kharakteristik krovi v izmerenii ee tekuchesti i transportnogo potentsiala. Rossiyskiy zhurnal biomekhaniki.[Investigation of the role of characteristics of blood in the measurement of its fluidity and transport capacity. Russian journal of biomechanics] 2012; 3 (57): 32-41 (in Russ.).</mixed-citation></ref><ref id="B7"><label>7.</label><mixed-citation>7. Nedoseikina T. V., Glukhov A. A., Korotkikh N. G. Sovremennye napravleniya kompleksnogo lecheniya bol'nykh s flegmonami chelyustno-litsevoy oblasti i shei. Fundamental'nye issledovaniya. [Modern trends in the complex treatment of patients with phlegmons of maxillofacial area and neck. The fundamental research] 2014; 4-3: 641-646 (in Russ.).</mixed-citation></ref><ref id="B8"><label>8.</label><mixed-citation>8. Yamurkova N. F. Strukturnaya kharakteristika vospalitel'nykh zabolevaniy chelyustno-litsevoy oblasti po gospitalizirovannoy zabolevaemosti vzroslogo naseleniya krupnogo goroda za desyatiletniy period i prognosticheskie tendentsii. Stomatologiya [Structural characteristic of inflammatory diseases of maxillofacial area for hospitalized morbidity of adult population of a large city over the ten year period and forecasting trends. Dentistry] 2007; 4: 28-34 (in Russ.).</mixed-citation></ref><ref id="B9"><label>9.</label><mixed-citation>9. Artmann G.M. Microscopic photometric quantification of stiffness and re-laxation time of red blood cells in a flow chamber. Biorheology. 1995; 5: 553-570.</mixed-citation></ref><ref id="B10"><label>10.</label><mixed-citation>10. Baskurt O.K., Meiselman H.J. Erythrocyte aggregation: basic aspects and clinical importance. Clinical Hemorheology and Microcirculation. 2013; 53 (1-2): 23-37.</mixed-citation></ref><ref id="B11"><label>11.</label><mixed-citation>11. Baskurt O.K., Hardeman M.R., Rampling M.W., Meiselman H.J. Handbook of Hemorheology and Hemodynamics Biomedical and Health Research. Amsterdam - Berlin - Oxford - Tokyo - Washington, DC IOS Press. 2007; 69: 468.</mixed-citation></ref><ref id="B12"><label>12.</label><mixed-citation>12. Broughton G., Janis J.E., Attinger C.E. The basic science of wound heal-ing. Plastic and Reconstructive Surgery. 2006; 117</mixed-citation></ref><ref id="B13"><label>13.</label><mixed-citation>(7): 12-34.</mixed-citation></ref><ref id="B14"><label>14.</label><mixed-citation>13. Flynn T.R. The swollen face. Severe odontogenic infections. Emergency Medicine Clinics of North America. 2000; 18 (3):</mixed-citation></ref><ref id="B15"><label>15.</label><mixed-citation>481-519.</mixed-citation></ref><ref id="B16"><label>16.</label><mixed-citation>14. Jarboui S., Jerraya H., Moussi A. et al. Descending necrotizing</mixed-citation></ref><ref id="B17"><label>17.</label><mixed-citation>mediasti-nitis of odontogenic origin. Tunisia Medical. 2009; 87</mixed-citation></ref><ref id="B18"><label>18.</label><mixed-citation>(11): 770-5.</mixed-citation></ref><ref id="B19"><label>19.</label><mixed-citation>15. Marossy A., Svorc P., Kron I., Gresova S. Hemorheology and circulation. Clinical Hemorheology and Microcirculation. 2009;</mixed-citation></ref><ref id="B20"><label>20.</label><mixed-citation>42 (4): 239-58.</mixed-citation></ref><ref id="B21"><label>21.</label><mixed-citation>16. Pries A.R., Secomb T.W. Rheology of the microcirculation.</mixed-citation></ref><ref id="B22"><label>22.</label><mixed-citation>Clinical Hemorheology and Microcirculation. 2003; 29 (3-4):</mixed-citation></ref><ref id="B23"><label>23.</label><mixed-citation>143-8.</mixed-citation></ref><ref id="B24"><label>24.</label><mixed-citation>17. Stoltz J.F., Donner M. New trends in clinical hemorheology: an introduc-tion to the concept of the hemorheological profile. Schweizerische medizinische Wochenschrift. 1991; 43: 41-49.</mixed-citation></ref><ref id="B25"><label>25.</label><mixed-citation>18. Van Dort H.M., Knowles D.W., Chasis J.A. Lee G, Mohandas N., Low P.S. Analysis of integral membrane protein contributions to the deformability and stability of the human erythrocyte membrane. Journal of Biological Chemistry. 2001; 276: 968-974.</mixed-citation></ref><ref id="B26"><label>26.</label><mixed-citation>19. Wang J., Ahani A., Pogrel M.A. A five-year retrospective study of odon-togenic maxillofacial infections in a large urban public hospital. International Journal of Oral and Maxillofacial Surgery. 2005; 34 (6): 646-9.</mixed-citation></ref><ref id="B27"><label>27.</label><mixed-citation>20. Youssef O.H., Stefanyszyn M.A., Bilyk J.R. Odontogenic orbital cellulitis. Ophthalmic Plastic and Reconstructive Surgery. 2008;</mixed-citation></ref><ref id="B28"><label>28.</label><mixed-citation>24 (1): 29-35.</mixed-citation></ref></ref-list></back></article>
