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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="research-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Journal of Experimental and Clinical Surgery</journal-id><journal-title-group><journal-title xml:lang="en">Journal of Experimental and Clinical Surgery</journal-title><trans-title-group xml:lang="ru"><trans-title>Вестник экспериментальной и клинической хирургии</trans-title></trans-title-group></journal-title-group><issn publication-format="print">2070-478X</issn><issn publication-format="electronic">2409-143X</issn><publisher><publisher-name xml:lang="en">Voronezh State Medical University named after N.N. Burdenko</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">957</article-id><article-id pub-id-type="doi">10.18499/2070-478X-2012-5-1-145-153</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Original articles</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Оригинальные статьи</subject></subj-group><subj-group subj-group-type="article-type"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Mechanical circulatory support – a report from Europe’s largest single-center experience</article-title><trans-title-group xml:lang="ru"><trans-title>Механическая поддержка кровообращения – опыт самой большой в Европе программы «искусственное сердце»</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Stepanenko</surname><given-names>Alexandr Vladimirovich</given-names></name><name xml:lang="ru"><surname>Степаненко</surname><given-names>Александр Владимирович</given-names></name></name-alternatives><address><country country="DE">Germany</country></address><bio xml:lang="en"><p>Surgeon-trainee of cardiothoracic and vascular surgery department</p></bio><bio xml:lang="ru"><p>Хирург-стажер отделения кардиоторакальной и сосудистой хирургии</p></bio><email>stepanenko@dhzb.de</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Romantschenko</surname><given-names>Olga Anatol'evna</given-names></name><name xml:lang="ru"><surname>Романченко</surname><given-names>Ольга Анатольевна</given-names></name></name-alternatives><address><country country="DE">Germany</country></address><bio xml:lang="en"><p>Surgeon-trainee of cardiothoracic and vascular surgery department</p></bio><bio xml:lang="ru"><p>Хирург-стажер отделения кардиоторакальной и сосудистой хирургии</p></bio><email>romanchenko@dhzb.de</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Dubaev</surname><given-names>Aslanbek Asludinovich</given-names></name><name xml:lang="ru"><surname>Дубаев</surname><given-names>Асланбек Аслудинович</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Assistant of the Department of Hospital Surgery, Voronezh State Medical Academy named after N. N. Burdenko</p></bio><bio xml:lang="ru"><p>ассистент кафедры госпитальной хирургии Воронежской государственной медицинской академии им. Н.Н.Бурденко</p></bio><email>dr.aslanbec@mail.ru</email><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Dranishnikov</surname><given-names>Nikolai Vitalyevich</given-names></name><name xml:lang="ru"><surname>Дранишников</surname><given-names>Николай Витальевич</given-names></name></name-alternatives><address><country country="DE">Germany</country></address><bio xml:lang="en"><p>Surgeon-stager of cardiothoracic and vascular surgery department</p></bio><bio xml:lang="ru"><p>Хирург-стажер отделения кардиоторакальной и сосудистой хирургии </p></bio><email>dranishnikov@dhzb.de</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Schweiger</surname><given-names>Martin</given-names></name><name xml:lang="ru"><surname>Швайгер</surname><given-names>Мартин</given-names></name></name-alternatives><address><country country="DE">Germany</country></address><bio xml:lang="en"><p>Doctor of Medical Sciences, doctor of cardiothoracic and vascular surgery department</p></bio><bio xml:lang="ru"><p>Доктор медицинских наук, врач отделения кардиоторакальной и сосудистой хирургии</p></bio><email>mschweiger@dhzb.de</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Viereke</surname><given-names>Juliane</given-names></name><name xml:lang="ru"><surname>Фиреке</surname><given-names>Юлиане</given-names></name></name-alternatives><address><country country="DE">Germany</country></address><bio xml:lang="en"><p>Doctor of cardiothoracic and vascular surgery</p></bio><bio xml:lang="ru"><p>Врач отделения кардиоторакальной и сосудистой хирургии</p></bio><email>vierecke@dhzb.de</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Potapov</surname><given-names>Evgeniy Vladimirovich</given-names></name><name xml:lang="ru"><surname>Потапов</surname><given-names>Е. В.</given-names></name></name-alternatives><address><country country="DE">Germany</country></address><bio xml:lang="en"><p>Doctor of medical sciences, privat-docent, doctor of cardiothoracic and vascular surgery department</p></bio><bio xml:lang="ru"><p>Доктор медицинских наук, приват-доцент, врач отделения кардиоторакальной и сосудистой хирургии</p></bio><email>potapov@dhzb.de</email><xref ref-type="aff" rid="aff3"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Pasic</surname><given-names>Miralem</given-names></name><name xml:lang="ru"><surname>Пасич</surname><given-names>Миралем</given-names></name></name-alternatives><address><country country="DE">Germany</country></address><bio xml:lang="en"><p>Doctor of Medical Sciences, Professor, Senior Physician, Department of Cardiothoracic and Vascular Surgery, Deputy Director</p></bio><bio xml:lang="ru"><p>Доктор медицинских наук, профессор, старший врач отделения кардиоторакальной и сосудистой хирургии, зам. директора Немецкого кардиоцентра Берлина</p></bio><email>pasic@dhzb.de</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Weng</surname><given-names>Yuguo</given-names></name><name xml:lang="ru"><surname>Венг</surname><given-names>Югуо</given-names></name></name-alternatives><address><country country="DE">Germany</country></address><bio xml:lang="en"><p>Doctor of Medical Sciences, Professor, Senior Physician, Department of Cardiothoracic and Vascular Surgery, Deputy Director</p></bio><bio xml:lang="ru"><p>Доктор медицинских наук, профессор, старший врач отделения кардиоторакальной и сосудистой хирургии, зам. директора </p></bio><email>weng@dhzb.de</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Huebler</surname><given-names>Michael</given-names></name><name xml:lang="ru"><surname>Хюблер</surname><given-names>Михаэль</given-names></name></name-alternatives><address><country country="DE">Germany</country></address><bio xml:lang="en"><p>Doctor of Medical Sciences, Professor, Senior Physician, Department of Cardiothoracic and Vascular Surgery, Deputy Director</p></bio><bio xml:lang="ru"><p>Доктор медицинских наук, профессор, старший врач отделения кардиоторакальной и сосудистой хирургии, заместитель директора</p></bio><email>huebler@dhzb.de</email><xref ref-type="aff" rid="aff3"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Hetzer</surname><given-names>Roland</given-names></name><name xml:lang="ru"><surname>Хетцер</surname><given-names>Роланд</given-names></name></name-alternatives><address><country country="DE">Germany</country></address><bio xml:lang="en"><p>Doctor of Medical Sciences, Professor, Multidisciplinary Professor (Burma State Medical University, MV Lomonosov Moscow State University, NI Pirogov National Medical and Surgeon Center, All-Russian Center for Emergency and Radiation Medicine AM Nikiforova EMERCOM of Russia, Warsaw University of Cardinal Stefan Vyshinsky, University of Sarajevo, 2nd Medical University in Shanghai, Fujian University), German Cardiology Center Berlin / Director of medical service</p></bio><bio xml:lang="ru"><p>Доктор медицинских наук, мультипочетный профессор (ВГМА им. Н.Н. Бурденко, МГУ им. М.В. Ломоносова, Национальный Медико-хирургический Центр им. Н.И. Пирогова, Всероссийский Центр экстренной и радиационной медицины им. А.М. Никифорова МЧС России, Варшавский ун-т им. Кардинала Стефана Вышинского, ун-т в Сараево, 2-й мед. ун-т в Шанхае, Фуцзяньский ун-т), Немецкий кардиоцентр Берлина/ директор врачебнойслужбы</p></bio><email>hetzer@dhzb.de</email><xref ref-type="aff" rid="aff3"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Krabatsch</surname><given-names>Tomas</given-names></name><name xml:lang="ru"><surname>Крабач</surname><given-names>Томас</given-names></name></name-alternatives><address><country country="DE">Germany</country></address><bio xml:lang="en"><p>Doctor of Medical Sciences, privat-dots., Honorary Professor of Voronezh State Medical University. NN Burdenko, senior physician of Cardiothoracic and Vascular Surgery Department, Deputy Director</p></bio><bio xml:lang="ru"><p>Доктор медицинских наук, приват-доцент, почетный профессор Воронежского государственного медицинского университета им.Н.Н.Бурденко, старший врач отделения кардиоторакальной и сосудистой хирургии, зам. директора Немецкого кардиоцентра Бер-лина</p></bio><email>krabatsch@dhzb.de</email><xref ref-type="aff" rid="aff3"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">German Cardiology Center of Berlin</institution></aff><aff><institution xml:lang="ru">Немецкий Кардиоцентр Берлина</institution></aff></aff-alternatives><aff-alternatives id="aff2"><aff><institution xml:lang="en">Voronezh State Medical University named after N.N. Burdenko</institution></aff><aff><institution xml:lang="ru">Воронежский государственный медицинский университет имени Н.Н.Бурденко</institution></aff></aff-alternatives><aff-alternatives id="aff3"><aff><institution xml:lang="en">German Cardiology Center of Berlin</institution></aff><aff><institution xml:lang="ru">Немецкий Кардиоцентр Берлина, Германия</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2012-01-19" publication-format="electronic"><day>19</day><month>01</month><year>2012</year></pub-date><volume>5</volume><issue>1</issue><issue-title xml:lang="ru"/><fpage>145</fpage><lpage>153</lpage><history><date date-type="received" iso-8601-date="2017-03-09"><day>09</day><month>03</month><year>2017</year></date><date date-type="accepted" iso-8601-date="2017-04-02"><day>02</day><month>04</month><year>2017</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2012, Voronezh N.N. Burdenko State Medical University</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2012, ФГБОУ ВО ВГМУ им. Н.Н. Бурденко Минздрава России</copyright-statement><copyright-year>2012</copyright-year><copyright-holder xml:lang="en">Voronezh N.N. Burdenko State Medical University</copyright-holder><copyright-holder xml:lang="ru">ФГБОУ ВО ВГМУ им. Н.Н. Бурденко Минздрава России</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/" start_date="2017-11-19"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://vestnik-surgery.com/journal/about/editorialPolicies</ali:license_ref></license></permissions><self-uri xlink:href="https://vestnik-surgery.com/journal/article/view/957">https://vestnik-surgery.com/journal/article/view/957</self-uri><abstract xml:lang="en"><p>The implantation of ventricular assist devices (VADs) is a valuable option in patients with end-stage heart failure. The number of VAD implantations is growing worldwide. Between 7/1987 and 7/2010 we implanted 1598 VADs in 1455 patients. The majority were male (81.0 %), and their mean age was 49.4 years (range 0.3 days to 82). Indications for implantation were: cardiomyopathy (n=1074), postcardiotomy heart failure (n=282), acute myocardial infarction (n=83), graft failure after heart transplantation (n=64), and others (n=61). In 55.5% the VAD implanted was left ventricular, in 39.5% biventricular and in 4.8% right ventricular. Until 1995 the implanted pumps were mostly pulsatile. Today, however, more than 95% of the implanted VADs are continuous-flow rotary pumps. The average support time was 148.6 (range 0 to 1836) days. The percentage of biventricular VADs has dropped over the years to 20% in 2009. 347 patients could be successfully bridged to heart transplantation. In 122 patients (8.3%) the device could be explanted after myocardial recovery. In 2009 31.4% of the patients were implanted for permanent support. During the study period 521 patients could be discharged home or to a rehabilitation center. Implantation of ventricular assist devices is now an established treatment for patients with both acute and chronic end-stage heart failure. Small implantable left ventricular assist devices of the second and third generation are now broadly employed worldwide with growing acceptance and decreasing complications. The percentage of biventricular support has dropped over the years to 20%.</p></abstract><trans-abstract xml:lang="ru"><p>Имплантация систем механической поддержки кровообращения (СМПК) является ценной возможностью лечения пациентов, страдающих терминальной сердечной недостаточностью, рефрактерной к медикаментозной терапии. В мире количество имплантаций подобных систем растет год от года. В период с июля 1987 по июль 2010 года имплантировано 1598 систем механической поддержки кровообращения 1455 пациентам. Большинство пациентов – мужчины (81%), средний возраст 49,4 года (с вариацией возраста от 8 часов до 82 лет). Показаниями к применению СМПК являлись: кардиомиопатия (n =1074), посткардиотомический синдром сердечной слабости (n =282), острый инфаркт миокарда (n=83), острая сердечная слабость после трансплантации сердца (n =64), прочее (n =61). В 55,5% случаев использовался искусственный левый желудочек сердца, в 39,5% - бивентрикулярная поддержка кровообращения и в 4,8% - правожелудочковый обход. До 1995 года преимущественно применялись СМПК с пульсовым режимом работы. В настоящее время более 95% всех имплантируемых систем – это системы постоянного тока крови. Среднее время поддержки кровообращения составило 148,6 дней (вариация от 0 до 1836 дней). Процент использования бивентрикулярной поддержки кровообращения за годы применения СМПК снизился до 20% к 2009 году. 347 пациентам успешно произведена трансплантация сердца после применения СМПК. У 122 пациентов (8.3%) наступило оздоровление миокарда, что позволило эксплантировать СМПК. В 2009 году у 31,4% пациентов механическая поддержка была применена как альтернатива трансплантации сердца. За время исследования 521 пациент был выписан из клиники для амбулаторного наблюдения домой или в реабилитационный центр. Имплантация систем механической поддержки кровообращения в настоящее время является стандартным методом лечения как острой, так и хронической рефрактерной к консервативной терапии терминальной сердечной недостаточности. Миниатюрные имплантируемые СМПК второго и третьего поколения являются самыми широко применяемыми во всем мире с растущимакцептированием этого метода лечения обществом и уменьшением количества осложнений. Процент использования бивентрикулярных систем поддержки кровообращения снизился за последнее время до 20%.</p></trans-abstract><kwd-group xml:lang="en"><kwd>heart failure</kwd><kwd>cardiomyopathy</kwd><kwd>mechanical circulatory support</kwd><kwd>artificial ventricle</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>сердечная недостаточность</kwd><kwd>кардиомиопатия</kwd><kwd>механическая поддержка кровообращения</kwd><kwd>искусственный желудочек сердца</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>1. Hausmann H., Topp H., Siniawski H., Holz S., Hetzer R. 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