Journal of Experimental and Clinical SurgeryJournal of Experimental and Clinical SurgeryВестник экспериментальной и клинической хирургии2070-478X2409-143XVoronezh State Medical University named after N.N. Burdenko96210.18499/2070-478X-2012-5-1-131-136Original articlesОригинальные статьиResearch ArticleAn experimental justification of using jet sanitization and platelet concentrate in the treatment of chronic osteomyelitis of cortical bonesЭкспериментальное обоснование применения струйной санации и тромбоцитарного концентрата в лечении хронического остеомиелита длинных трубчатых костейGlukhovAlexander AnatolievichГлуховАлександр Анатольевич
Russian Federation

Doctor of Medical Sciences, Professor, Head of the Department of General Surgery, Director of the Institute of Surgical Infection, Voronezh State Medical University. N. N. Burdenko

доктор медицинских наук, профессор, заведующий кафедрой общей хирургии, директор института хирургической инфекции Воронежского государственного медицинского университета им. Н.Н.Бурденко

surgery-v@ya.ruAlekseevaNatalia TimofeevnaАлексееваНаталья Тимофеевна
Russian Federation

Candidate of Medical Science, assistant professor of the Department of Normal Human Anatomy of the Voronezh State Medical University. N. N. Burdenko

Кандидат медицинских наук, доцент кафедры нормальной анатомии человека Воронежского государственного медицинского университета им. Н.Н.Бурденко

alexeevant@list.ruMikulichElena ViktorovnaМикуличЕлена Викторовна
Russian Federation

Assistent of the Department of General Surgery Voronezh State Medical University. N. N. Burdenko

ассистент кафедры общей хирургии Воронежского государственного медицинского университета им. Н.Н.Бурденко

alenkamik@yandex.ruVoronezh State Medical University named after N. N. BurdenkoВоронежский государственный медицинский университет имени Н.Н.Бурденко19012012511311360903201713042017Copyright ©; , Glukhov A.A., Alekseeva N.T., Mikulich E.V.Copyright ©; , Глухов А.А., Алексеева Н.Т., Микулич Е.В.Glukhov A.A., Alekseeva N.T., Mikulich E.V.Глухов А.А., Алексеева Н.Т., Микулич Е.В.http://creativecommons.org/licenses/by-nc-nd/4.0https://vestnik-surgery.com/journal/article/view/962

The results of complex treatment of chronic osteomyelitis of cortical bones. The experiment was carried out on 56 outbred rats.To study the dynamics of structural and functional changes produced in the bone histological and radiological investigationwere hold. The data obtained indicate that the use of jet reorganization and platelet concentrate is an effective guide forachieving the desired results in the treatment of chronic osteomyelitis.

Представлены результаты комплексного лечения хронического остеомиелита длинных трубчатых костей. Эксперимент проведен на 56 беспородных крысах. Для изучения динамики структурно-функциональных изменений в кости выполнены гистологическое и рентгенологическое исследование. Полученные данные свидетельствуют о том, что применение струйной санации и тромбоцитарного концентрата является эффективным пособием для достижения искомых результатов в лечении хронического остеомиелита.

chronic osteomyelitis, stream sanitization, platelet concentrateхронический остеомиелит, струйная санация, тромбоцитарный концентрат1. Alekseyev D.G. Kompleksnoye lecheniye khronicheskogo osteomiyelita s primeneniyem ratsional'noy antiinfektsionnoy khimioterapii i immunokorrektsii [Complex treatment of chronic osteomyelitis with the use of rational anti-infectious chemotherapy and immunocorrection]: avtoref. dis. ... kand. med. nauk. Samara 2005; 22.2. Badikov V.D. Mikrobiologiya boyevoy khirurgicheskoy travmy [Microbiology of combat surgical trauma]: avtoref. dis. d-ra med. nauk. – SPb 2000;41.3. Batakov V.Ye. Primeneniye plazmennogo autofibronektina v kompleksnom lechenii khronicheskogo osteomiyelita [The use of plasma autofibronectin in the complex treatment of chronic osteomyelitis]: dis. … kand. med. nauk. Samara.2010; 139.4. Gostishchev V.K., Shalchkova L.P., Melik-Dadayeva G.P. Sravnitel'naya otsenka razlichnykh vidov sanatsii i plastiki posleoperatsionnykh kostnykh polostey pri khirurgicheskom lechenii bol'nykh khronicheskim posttravmaticheskim osteomiyelitom dlinnykh trubchatykh kostey. [Comparative evaluation of different types of sanation and plasty of postoperative bone cavities during surgical treatment of patients with chronic posttraumatic osteomyelitis of long tubular bones.] Tez. dokl. 1-y Belorus. mezhdunar. kongressa khirurgov. Vitebsk.1996; 20-22.5.Kuznetsov N.A., Nikitin V.G., Teleshova Ye.B., Mil'chakov A.A. Antiseptiki i biodegradiruyushchiye implanty v lechenii khronicheskogo posleoperatsionnogo osteomiyelita. [Kuznetsov N.A., Nikitin V.G., Teleshova Ye.B., Mil'chakov A.A. Antiseptiki i biodegradiruyushchiye implanty v lechenii khronicheskogo posleoperatsionnogo osteomiyelita. Khirurgiya] Khirurgiya 2009; 5: 31–35.6. Ladonin S.V., Belozertseva Ye.A. Eksperimental'noye obosnovaniye ispol'zovaniya allogennogo demineralizovannogo kostnogo implantata v kompleksnom lechenii khronicheskogo osteomiyelita. [Experimental substantiation of the use of allogenic demineralized bone implant in the complex treatment of chronic osteomyelitis.] Morfologicheskiye vedomosti 2011; 1: 101-106.7. Makhson N.Ye. Posttravmaticheskiy osteomiyelit. [Post-traumatic osteomyelitis.] Vrach. 2001; 6: 8-10.8. Miromanov A.M., Mironova O.B., Busoyedov A.V., Miromanova N.A., Vitkovskiy YU.A. Sposob prognozirovaniya razvitiya khronicheskogo osteomiyelita dlinnykh konechnostey. [A method for predicting the development of chronic osteomyelitis of long limbs.] Vestnik eksperimental'noy i klinicheskiy khirurgii 2011; IV: 4: 751–756.9. Nikitin, G.D., Rak A.V., Linnik S.A. Khirurgicheskoye lecheniye osteomiyelita. [Surgical treatment of osteomyelitis] SPb. 2000; 286.10. Sonis A.G. Novoye v diagnostike i lechenii osteomiyelita [New in the diagnosis and treatment of osteomyelitis: author's abstract.]: avtoref. dis. ... d-ra med. nauk. Samara.2010; 42.11. Stolyarov Ye.A., Batakov Ye.A., Ishutov I.V., Ladonin S.V. Khronicheskiy osteomiyelit – sovremennoye sostoyaniye problemy. [Chronic osteomyelitis - the current state of the problem.] Samarskiy meditsinskiy zhurnal.2004;5-6: 28-30.12. Omel'yanenko N.P., Slutskiy L.I. Soyedinitel'naya tkan' (gistofiziologiya i biokhimiya). [Connective tissue (histophysiology and biochemistry).] Pod red. Akademika RAN i RAMN S.P. Mironova. M.: Izdatel'stvo «Izvestiya». 2010; 2: 600.13. Khasanov A.G., Nutridinov M.A., Nigmatzyanov S.S., Sakayev R.SH. Rezul'taty primeneniya plazmennykh potokov v kompleksnom lechenii khronicheskogo osteomiyelita. [Results of application of plasma flows in the complex treatment of chronic osteomyelitis.]Vestnik eksperimental'noy i klinicheskoy khirurgii. 2010; III . 3: 207-209.14. Feltsan T., Mracna J., Holly D. Ispol'zovanie trombocitov14. Feltsan T., Mracna J., Holly D. Ispol'zovanie trombocitov Koncentraty v lechenii kostnyh defektov [Use of thrombocyte concentrates in treatment of bone defects.] Bratisl Lek Listy. 2011; 12: 11: 655-657.Koncentraty v lechenii kostnyh defektov [Use of thrombocyte15. Filardo G. Intraartikulyarnye in"ekcii s vysokim soderzhaniem trombocitov Dlya degeneracii hryashcha i osteoartrita: singleversus Metod dvojnogo pryadeniya. [Platelet-rich plasma intra-articular injections for cartilage degeneration and osteoarthritis: singleversusconcentrates in treatment of bone defects.] Bratisl Lek Listy.double-spinning approach.] Knee Surg Sports Traumatol Arthrosc. US National Library of Medicine National Institutes of Health [Элек-2011; 12: 11: 655-657.тронный ресурс]: URL http://www.ncbi.nlm.nih.gov/ pubmed/2220304615. Filardo G. Intraartikulyarnye in"ekcii s vysokim soderzhaniem trombocitov16. Messora M.R., Nagata M.J., Dornelles R.C., Bomfim S.R., Furlaneto F.A., de Melo L.G., Deliberador T.M., BoscoDlya degeneracii hryashcha i osteoartrita: singleversus Metod dvojnogo pryadeniya. [Platelet-rich plasma intra-articular injectionsA.F., Garcia V.G., Fucini S.E. Iscelenie kostej v kriticheskih razmerah Defekty, obrabotannye trombocitarnoj plazmoj, aktivirovannoj dvumya Raznye metody. Gistologicheskoe i gistometricheskoe issledovanie na krysah Kal'variya. [Bone healing in critical-size defects treated with platelet-rich plasma activated by two different methods. A histologic and histometric study in ratfor cartilage degeneration and osteoarthritis: singleversuscalvaria.] J Periodontal Res. 2008; 43: 6: 723-729.double-spinning approach.] Knee Surg Sports17. Oryan A. Vozdejstvie kombinirovannogo gidroksiapatita i Bogataya trombocitami plazma na zazhivlenii kosti u krolika Model': radiologicheskaya, makroskopicheskaya, gidtopatologicheskaya I biomekhanicheskaya ocenka [Effects of combined hydroxyapatite and human platelet rich plasma on bone healing in rabbitTraumatol Arthrosc. US Nationalmodel: radiological, macroscopical, hidtopathological and biomechanical evaluation.] Cell Tissue Bank. [Epub ahead of print]. US National Library of Medicine National Institutes of Health [Электронный ресурс] URL http://www.ncbi. nlm.nih.gov/pubmed/22180011.Library of Medicine National Institutes of Health [Элек-18. Pietramaggiori G. Pokazano, chto liofilizirovannaya plazma, bogataya trombocitami Poleznye celebnye svojstva pri hronicheskih ranah [Freeze-dried platelet-rich plasma shows beneficial healing properties in chronic wounds.] Wound Repair. Regen. 2006; 14: 5: 573-580.тронный ресурс]: URL http://www.ncbi.nlm.nih.gov/pubmed/2220304616. Messora M.R., Nagata M.J., Dornelles R.C., Bomfim S.R.,Furlaneto F.A., de Melo L.G., Deliberador T.M., BoscoA.F., Garcia V.G., Fucini S.E. Iscelenie kostej v kriticheskih razmerahDefekty, obrabotannye trombocitarnoj plazmoj, aktivirovannoj dvumyaRaznye metody. Gistologicheskoe i gistometricheskoe issledovanie na krysahKal'variya. [Bone healing in critical-sizedefects treated with platelet-rich plasma activated by twodifferent methods. A histologic and histometric study in ratcalvaria.] J Periodontal Res. 2008; 43: 6: 723-729.17. Oryan A. Vozdejstvie kombinirovannogo gidroksiapatita iBogataya trombocitami plazma na zazhivlenii kosti u krolikaModel': radiologicheskaya, makroskopicheskaya, gidtopatologicheskayaI biomekhanicheskaya ocenka [Effects of combined hydroxyapatite andhuman platelet rich plasma on bone healing in rabbitmodel: radiological, macroscopical, hidtopathologicaland biomechanical evaluation.] Cell Tissue Bank. [Epubahead of print]. US National Library of Medicine NationalInstitutes of Health [Электронный ресурс] URL http://www.ncbi.nlm.nih.gov/pubmed/22180011.18. Pietramaggiori G. Pokazano, chto liofilizirovannaya plazma, bogataya trombocitamiPoleznye celebnye svojstva pri hronicheskih ranah [Freeze-dried platelet-rich plasma showsbeneficial healing properties in chronic wounds.] WoundRepair. Regen. 2006; 14: 5: 573-580.