Evaluating the Effectiveness of Ozonated Perftorana and Glutoksima in the Treatment of Generalized Peritonitis

The purpose of the study Was to study the performance of the immune system and cytokine profile in the patients with diffuse peritonitis and to correct these disorders to improve the results of the surgical treatment. Materials and methods The article analyzes the results of surgical treatment of 114 patients with generalized peritonitis (GP). The patients were divided into two groups. In the comparison group consisted of 38 patients who received conventional combination therapy, and a core group of 76 patients. The main group was divided into two subgroups. Patients 1st subgroups (n=40) in treatment since preoperative preparation ETA used intravenous infusion at a dose of 1 mg/kg ozone concentration of 5 mg/l. The second subgroup of patients (n=36) against systemic and local OT with OP as in the 1st subgroup further preoperatively prepared metabolic immunomodulator and detoxifier 2.0 ml of 1% glutoxim. All the patients blood before surgery, 1-3 , 5-7 and 10-14 days after the operation expression defined clusters CD3+, CD4+, CD8+, CD19+, CD4+/CD8+, phagocytic index, immunoglobulins (Jg A, M, G) and circulating immune complexes (CIC) and indicators of cytokines (TNFα, IL- 4 and IL- 8). Results and their discussion All patients in both groups at admission revealed changes in cellular and humoral immunity, phagocytosis, and cytokine balance compared with those in healthy individuals, the severity of which was dependent on the severity of peritonitis by MPI. Conclusion The results showed the effectiveness of the combined local and systemic application of the OP, OP especially with glutoxim in the complex treatment of patients with GP, which allows us to recommend them for wide clinical application.