Substantiation Study of Using Immobilized Cytostatics in Management of Tumors with Peritoneal Canceromatosis

Abstract


Relevance Despite the certain successes in early diagnostics of oncological diseases a considerable number of patients with the late-stage diseases including peritoneal canceromatosis are identified at the initial examination. The cytoreductive surgeries accompanied with injuries of peritoneal mesothelium may promote commissure appearance, commissure-tumor conglomerate formation and may result in developing the acute adhesive intestinal obstruction against the background of peritoneal canceromatosis. The purpose of the study The purpose of the study is to investigate the interaction between “Lintex-Mesogel” (manufactured by “Lintex”, St. Petersburg) and chemotherapy preparations traditionally used in the treatment of peritoneal canceromatosis – Cisplatin, 5-ftuorouracil and Cyclophosphanum Materials and methods The physicochemical investigation of the interaction between “Lintex-Mesogel” and chemotherapy preparations– Cisplatin, 5-ftuorouracil and Cyclophosphanum has been conducted by the ultraviolet-visible spectroscopy and infrared spectroscopy. Results and their discussion The research proves the chemical inertness of “Lintex-Mesogel” that allows using the immobilized forms of cytostaticsin managing patients with peritoneal canceromatosisalong withthe simultaneous prevention of commissure formation Conclusions The immobilization of the preparations mentionedabove into the “Lintex-Mesogel” structure promotes the controlled release of medical products providing the prolongation of their antitumoral action. Key words Cytostatics, carboxymethylcellulose, peritoneal canceromatosis

Kursk State Medical University, 3 K.Marksa Str., Kursk, 305041, Russian Federation

Author for correspondence.
Email: kursk_ood@mail.ru
MD, prof., head of the department of oncology, Kursk State Medical University.

Kursk oncologic dispensary, 20 Pirogova Str., Kursk, 305035, Russian Federation

Email: kursk_ood@mail.ru
Ph.D., associate prof., department of oncology, Kursk State Medical University.

Kursk State Medical University, 3 K.Marksa Str., Kursk, 305041, Russian Federation

Email: kursk_ood@mail.ru
Ph.D., associate prof., department of oncology, Kursk State Medical University.

Kursk oncologic dispensary, 20 Pirogova Str., Kursk, 305035, Russian Federation

Email: kursk_ood@mail.ru
the head of the 1 st surgical department.

Kursk State Medical University, 3 K.Marksa Str., Kursk, 305041, Russian Federation

Email: SukovatykhBS@kursksmu.net
MD, Prof., the head of the department of General Surgery, Kursk State Medical University.

Kursk State Medical University, 3 K.Marksa Str., Kursk, 305041, Russian Federation

Email: nixonfrol@mail.ru
assistant prof., department of oncology, Kursk State Medical University.

Voronezh State University, 1 Universitetskaia Sq., Voronezh, 394006, Russian Federation

Email: vms159@mail.ru
MD, prof., head of the department of polymer science and colloids, Voronezh State University.

Voronezh State University, 1 Universitetskaia Sq., Voronezh, 394006, Russian Federation

Email: vms159@mail.ru
MD, prof. of the department of polymer science and colloids, Voronezh State University.

Kursk oncologic dispensary, 20 Pirogova Str., Kursk, 305035, Russian Federation

Email: kursk_ood@mail.ru
a surgeon of the department of oncology.

  1. Belyayev A.M., Bagnenko S.F., Rukhlyada N.V. Vnutribryushnaya khimioterapiya zlokachestvennykh opukholey bryushnoy polosti. [Intraperitoneal chemotherapy of malignant tumors of the abdominal cavity]. Monografiya. SPb .: «ELBI-SPb», 2007; 254.
  2. Verbitskiy D.A. Primeneniye gelya karboksimetiltsellyulozy dlya profilaktiki spaykoobrazovaniya v bryushnoy polosti [Use of carboxymethylcellulose gel for the prevention of adhesions in the abdominal cavity]: avtoref. dis. ... Kand. med nauk. Sankt-Peterburgskaya gosudarstvennaya pediatricheskaya akademiya, Sankt-Peterburg, 2004; 32.
  3. Lipatov V.A. Obosnovaniye primeneniya gelya karboksimetiltsellyulozy dlya profilaktiki posleoperatsionnogo spayechnogo protsessa bryushnoy polosti (eksperimental'noye issledovaniye). [Rationale for the use of carboxymethylcellulose gel for the prevention of postoperative adhesions of the abdominal cavity (experimental research)]. Diss. na soiskaniye uchenoy stepeni kandidata meditsinskikh nauk. Kurskiy gosudarstvennyy meditsinskiy universitet. Kursk, 2004; 148.
  4. Sutyagin V.M., Lyapkov A.A. Uchebnoye posobiye. Fiziko-khimicheskiye metody issledovaniya polimerov. [Tutorial. Physical and chemical research methods of polymers]. Tomsk: Izd-vo Tomskogo politekhnicheskogo universiteta, 2008; 130.
  5. Rogovin 3.A., Khimiya tsellyulozy [Cellulose Chemistry]. M., 1972; 519.
  6. Sugarbaker P.H.Peritoneal'nyy kartsinomatoz: novyye onkologicheskiye granitsy.[Peritoneal carcinomatosis: a new oncologic frontier]. Curr. Opin.Oncol., 2005; 17: 397-399.
  7. Yang S.H., Lin J.K., Lai C.R. et al.Faktory riska dlya peritoneal'nogo rasprostraneniya kolorektal'nogo raka. [Risk factors for peritoneal dissemination of colorectal cancer]. J. Surg. Oncol., 2004; 87: 167–173.
  8. Sugarbaker Р.H. Upravleniye peritoneal'noy poverkhnost'yu so zlokachestvennoy opukhol'yu s pomoshch'yu vnutribryushinnoy khimioterapii i tsitoreduktivnoy khirurgii.[Management of peritoneal surface malignancy using intraperitoneal chemotherapy and cytoreductive surgery]. Washington, 1998; 59.
  9. Jayne D.G., Fook S., Loi C. et al.Peritoneal'nyy kartsinomatoz ot kolorektal'nogo raka. [Peritoneal carcinomatosis from colorectal cancer]. Br. J. Surg., 2002; 89: 1545–1550.
  10. Sadeghi B., Arvieux C., Glehen O. et al.Peritoneal'nyy kartsinomatoz.[Peritoneal carcinomatosis]. Cancer, 2000; 88: 360-365.

Views

Abstract - 79

PDF (Russian) - 62

PlumX

Dimensions


Copyright (c) 2015 ., ., ., ., ., ., ., ., .

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies