Treatment of the Purulent Wounds Using Immobilized Forms of the Chlorgexedine Bigluconate


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Abstract

The purpose of the study Is to achieve better results of topical wound treatment of the purulent inflammatory soft tissue processes using an immobilized form of the chlorgexedine bigluconate in the first stage of wound healing. Materials and methods The investigated material is an immobilized form of the chlorgexedine bigluconate consisting of: chlorgexedine bigluconate 0,05% - 100,0; sodium nitrate of carboxymethylcellulose– 4,0; purified water– 100,0. An analysis of complex examination and treatment of 58 patients suffered from purulent wounds has been accomplished. All patients were randomized into two groups. The first (control) group patients were treated using “Levomecol” whereas the second (investigated) group patients received treatment with immobilized forms of the chlorgexedine bigluconate. Dynamic changes of the wound healing were monitored by parametric, bacteriologic, and cytologic investigation methods. Results and their discussion The faster rate of wound size reduction is achieved in the second group then in control one on the 3rd day by 1,59%, on the 5th day – by 3,16%, on the 7th day – by 5,86%, on the 10th day – by 6,85%, on the 14th day –by 7,82%, on the 21st day – by 7,62%. In the second group the bacterial wound colonization (BWC in 1 gram of tissue) was lower then in control one on the 3rd day by 1,6х106 , on the 5th day – by 25,1х105 on the 7th day – by 76,9х104 , on the 10th day – by 2,4х104 %, on the 15th day – by 0,5х103 (р<0,05). The number of granulocytes in the second group was lower on the 3rd day by 11,8%, on the 5th day – by 14,2%, on the 7th day – by 8,8% , on the 10th day – by 5,2%. The number of fiberblasts in the second group was higher on the same terms by 4,55%, 5,8%, 3,6%, and 4,4% respectively. Conclusion Higher positive results are achieved in treatment of the purulent wounds using immobilized forms of the chlorgexedine bigluconate what is confirmed by results of parametric, bacteriologic, and cytologic investigation methods.

About the authors

Kursk State Medical University, 3 Karl Marks Str., Kursk, 305041, Russian Federation

Author for correspondence.
Email: SukovatykhBS@kursksmu.net
MD, Professor, the head of the department of General Surgery, Kursk State Medical University

Kursk State Medical University, 3 Karl Marks Str., Kursk, 305041, Russian Federation

Email: PankrushevaTA@kursksmu.net
Doctor of pharmaceutical science, Professor, the Head of the department of Pharmaceutical Technology, Kursk State Medical University

Kursk State Medical University, 3 Karl Marks Str., Kursk, 305041, Russian Federation

Email: obhirurgiya@gmail.com
Ph.D., the assistant of the department of General Surgery, Kursk State Medical University

Kursk State Medical University, 3 Karl Marks Str., Kursk, 305041, Russian Federation

Email: obhirurgiya@gmail.com
Ph.D., the head of the department of Purulent Surgery, Regional Budget Health Care Facility “Kursk City Clinical Hospital of Emergency Medical Service”, Kursk

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