The Influence of the Synthetic Analogue of Indolicidin on Reparative Regeneration of Skin in Thermal Burns

Abstract


The purpose of the study Was the analysis of the influence of the indolicidin (Ind. 21) on reparative regeneration of skin after burn trauma. Matherials and methods The investigation was carried out on 80 male Wistar rats, which were undergone the burn trauma of the skin of back of the IIIa-IIIb degree and the square of the burn was 18% of body surface. The investigated animals were divided on two groups of 40 rats in each one. 0,2 ml of physiological solution were injected to the control rats daily within 5 days after burn trauma, and synthetic analogue of natural antimicrobial peptide indolicidin in dose 100 mkg/kg was injected to experimental animals in the same manner. Results and their discussion It has been established, that significant increase of macrophages and fibroblasts amount and also the neutrophils and lymphocytes decrease were observed in cell infiltrate from the beginning of burn trauma in animal after Ind 21 injections as compared with rats of control group. Epithelialization and maturation of granulation tissue developed significantly rapider and were ended earlier than in control animals. Conclusion The results of investigation indicate that the using of indolicidin analogue stimulates the healing of burn wound and accelerates the development of inflammation phases.

Kursk State Medical University, 3 K. Marksa Str., Kursk, 305041, Russian Federation

Author for correspondence.
Email: author@vestnik-surgery.com

Russian Federation MD, Prof., KSMU Rector, Head of the Department of Surgical Diseases Faculty of Postgraduate Education

Kursk State Medical University, 3 K. Marksa Str., Kursk, 305041, Russian Federation

Email: author@vestnik-surgery.com

Russian Federation MD, Prof. of Pathophysiology department KSMU

Kursk State Medical University, 3 K. Marksa Str., Kursk, 305041, Russian Federation

Email: nickolya@yandex.ru

Russian Federation doctor of BMI KSCH

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