Role in Hypoxic Cascade Trigger Mechanisms of Acute Pancreatitis

Abstract


Relevance One understudied mechanisms of pathogenesis of acute pancreatitis (AP ) , the question remains significance hypoxic cascade trigger mechanisms of disease development. The purpose of the study Set the importance of hypoxic cascade trigger mechanisms of acute pancreatitis. Materials and methods Work carried out on 20 adult mongrel dogs of both sexes mature weight from 8.6 to 12.3 kg. Animals modeled edematous form OP. In terms of control studies (1 , 3 and 5 th day ) produced relaparotomii in pancreatic tissue examined intraoperatively microcirculation and tissue respiration indices . Body tissue biopsy was performed to investigate the free-radical processes , determine the qualitative and quantitative composition of lipids . For normal performance was studied their levels in 10 healthy animals. Results and their discussion Studies have shown that the development of the edematous form of acute pancreatitis maximum reduction in body tissue microcirculation with increased index of grafting ( 230% ) developed on the third day . Under the conditions of disturbed microcirculation , there is a deficiency of oxygen , which causes the phase separation processes of electron transport in mitochondria and , as a consequence, the appearance of free oxygen radicals which can initiate lipid peroxidation and activate phospholipase systems with membranodestruktivnym action. Conclusion The resulting factual material in a generalized form gives reason to postulate that one of the most important trigger of the pathogenetic mechanisms of acute pancreatitis is the circulatory hypoxia , which underlies the formation of hypoxic cascade triggering "run" membranodestruktivnyh processes

N.P. Ogarev Mordovia State University, 68 Bol'shevistskaia Str., Saransk, 430005, Russian Federation

Author for correspondence.
Email: vap.61@yandex.ru

Russian Federation – MD, Prof., Head of Department of Surgery Medical School VPO "MSU. NP Ogareva "

N.P. Ogarev Mordovia State University, 68 Bol'shevistskaia Str., Saransk, 430005, Russian Federation

Email: asg72@list.ru

Russian Federation - MD, Head. Department of Surgery, Faculty of Medicine Obninsk Institute of Nuclear Energy - branch FGAOU Institution "National Research Nuclear University" MiFi "

N.I. Pirogov Russian National Research Medical University, 1 Ostrovitianova Str., Moscow, 117997, Russian
Federation

Email: dr.suslov@rambler.ru

Russian Federation graduate student of Faculty Surgery VPO "Mordovia State University them. NP Ogareva".

N.I. Pirogov Russian National Research Medical University, 1 Ostrovitianova Str., Moscow, 117997, Russian
Federation

Email: author@vestnik-surgery.com

Russian Federation PhD, Associate Prof. of Histology Medical University " N.I. Pirogov Russian National Research Medical University"

N.P. Ogarev Mordovia State University, 68 Bol'shevistskaia Str., Saransk, 430005, Russian Federation

Email: vap.61@yandex.ru

Russian Federation MD, Department of Hospital Therapy №1 VPO "Russian State Medical University"

  1. Skutova V.A., Kasum'yan S.A., Abrosimov S.YU., CHajkovskij YU.YA. Diagnosticheskaya taktika pri ostrom destruktivnom pankreatite [Diagnostic tactics in acute destructive pancreatitis.] Vestnik ehksperimental'noj i klinicheskoj hirurgii, 2013; VI: 1: 74-79.
  2. Gusejnov A.Z., Karapysh D.V. Ostryj pankreatit kak mediko-social'naya problema v strukture urgentnoj abdominal'noj hirurgicheskoj patologii [Acute pancreatitis as a medical social problem in the structure of urgent surgical abdominal pathology.] Vestnik novyh medicinskih tekhnologij, 2010; XVII: 3: 198-200.
  3. Nazyrov F.G. Ostryj pankreatit [Acute pancreatitis.] Vestnik ehkstrennoj mediciny, 2010; 4: 8-14.
  4. Nedashkovskij EH.V. Ostryj pankreatit: rukovodstvo dlya vrachej [Acute pancreatitis: a guide for physicians.] Moskva: GEOTAR-Media, 2009; 272.
  5. Firsova V.G., Parshikov V.V. Destruktivnyj pankreatit: mekhanizmy gibeli kletki i ih vozmozhnoe klinicheskoe znachenie [Destructive pancreatitis: mechanisms of cell death and their possible clinical significance.] Vestnik ehksperimental'noj i klinicheskoj hirurgii, 2013; VI: 1: 100-106.
  6. Kubyshkin V.A. Ostryj pankreatit [Acute pancreatitis.] Tihookeanskij medicinskij zhurnal, 2009; 2: 48-52.
  7. Hackert T., Pfeil D., Hartwig W., Fritz S. Platelet function in acute experimental pancreatitis. [Platelet function in acute experimental pancreatitis.] Gastrointest Surg., 2007; 4: 439-444.

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