Application of Collagen Hydrolyzate and Hydropulse Action in the Treatment of Experimental Purulent Wounds

Abstract


Relevance Wound treatment is one of the most frequent nosology in structure of primary surgical care, whose importance increases at development infection. That leads to an increase in duration and cost of treatment, that enchance dysfunction of organs and systems, sepsis deaths. The purpose of the study To develop experimental method in complex treatment of purulent wounds,based on combined use of Hydroimpulsive sanitatation and applicator-injecting collagen hydrolyzate. Materials and methods Experimental studies on 192 white rats with purulent wounds of soft tissues in 8 study groups ,according of methods used regional impact, and combinations. A study of treatment effectiveness was assessed by clinical, planimetric, histological and histochemical studies. Results and their discussion It was found that combined use these methods is optimal and accelerates necrolysis processes , reduce bacterial contamination in wound surface to 7 days to the level of 10-102 microbes per gram on tissue, reducing the inflammatory infiltration, accelerates during proliferation, which is expressed in the stimulation of angiogenesis, formation and maturation of granulation tissue, followed by epithelialization, all of which helped to reduce the healing time of wound defect by an average of 27.9%. Conclusion 1. This method of complex treatment purulent wounds of soft tissues, based on the combined use of Hydroimpulsive rehabilitation and aspiration-injecting collagen hydrolyzate. 2. Application of this method allowed to reduce bacterial contamination in the wound surface to the 7th day before the 101-102 level of microbial cells in 1 g of tissue. 3. Use of method based on a combination of Hydroimpulsive rehabilitation and aspiration-injecting collagen hydrolyzate, contributes to a more pronounced positive dynamics of morphological and histochemical changes that manifests a decrease in swelling of tissues, accelerating the timing of the formation of fibrin and collagen epithelialization compared with the 1st control group

N.N.Burdenko Voronezh State Medical Academy, 10 Studencheskaia Str., Voronezh, 394036, Russian Federation

Author for correspondence.
Email: sugery@mail.ru

Russian Federation - MD, Deputy Director of the Research Institute of Surgical Infection on Scientific Work of the N.N. Burdenko Voronezh State Medical Academy.

N.N.Burdenko Voronezh State Medical Academy, 10 Studencheskaia Str., Voronezh, 394036, Russian Federation

Email: author@vestnik-surgery.com

Russian Federation - Post-Graduated Student the Department of General Surgery of the N.N. Burdenko Voronezh State Medical Academy;

N.N.Burdenko Voronezh State Medical Academy, 10 Studencheskaia Str., Voronezh, 394036, Russian Federation

Email: author@vestnik-surgery.com

Russian Federation Post-Graduated Student the Department of General Surgery of the N.N. Burdenko Voronezh State Medical Academy

Воронежская государственная медицинская академия им. Н.Н.Бурденко, ул. Студенческая, д. 10, Воронеж, 394036, Российская Федерация

Email: author@vestnik-surgery.com

Russian Federation д.м.н., проф., зав. кафедрой общей
хирургии, директор НИИ хирургической инфекции
Воронежской государственной медицинской акаде-
мии им. Н.Н.Бурденкод.м.н., проф., зав. кафедрой общей
хирургии, директор НИИ хирургической инфекции
Воронежской государственной медицинской акаде-
мии им. Н.Н.Бурденко

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