Pathomorphologic picture of the organs of the peritoneal cavity and the retroperitoneal space in case of the experimental syndrome of intra-abdominal hypertensia


Cite item

Full Text

Abstract

The article presents the results of experimental researches conducted on 20 piglets that had the model of the experimental syndrome of abdominal hypertensia. In the fi rst group of the animals intra-abdominal hypertensia was kept up at 15-20 mmHg for 6 hours, in Group II – 21-25 mm Hg, in Group III – 26-30 mmHg that corresponded to II, III, IV degrees of the syndrome of intra-abdominal hypertensia in accordance with the classifi cation developed by M.L.Cheatham (1995). The fi ndings have revealed a direct dependence of the degree of pathomorphologic changes of organs of the peritoneal cavity on the level of intra-abdominal pressure. The severest pathological changes up to necrotic processes were observed in case of intra-abdominal hypertensia when the level of intra-abdominal pressure was more than 26 mm Hg. The results of the research of the microcirculation of capillary blood fl ow and blood lactate performed by the laser analyzer have confi rmed the aggravation of ischemic damages of the organs when the severity of intra-abdominal hypertensia was increased. They correlate with pathomorphologic changes.

About the authors

Башкирский государственный медицинский университет

Author for correspondence.
Email: timersh@yandex.ru
кандидат медицинских наук, доцент кафедры хирургии с курсом эндоскопии ИПО Башкирского государственного медицинского университета

Башкирский государственный медицинский университет

Email: timersh@yandex.ru
доктор медицинских наук, профессор кафедры гистологии Башкирского государственного медицинского университета

Башкирский государственный медицинский университет

Email: timersh@yandex.ru
доктор медицинских наук, профессор кафедры хирургии с курсом эндоскопии ИПО Башкирского государственного медицинского университета

Башкирский государственный медицинский университет

Email: timersh@yandex.ru
доктор медицинских наук, профессор кафедры хирургии с курсом эндоскопии ИПО Башкирского государственного медицинского университета

Башкирский государственный медицинский университет

Email: sultanbaev@mail.ru
аспирант кафедры хирургии с курсом эндоскопии ИПО Башкирского государственного медицинского университета

Башкирский государственный медицинский университет

Email: timersh@yandex.ru
доктор медицинских наук, профессор, член-корреспондент РАМН, заведующий кафедрой хирургии с курсом эндоскопии ИПО Башкирского государственного медицинcкого университета

References

  1. Roshchin G.G. Sindrom abdominal'noi kompressii u bol'nykh s izolirovannoi travmoi zhivota. Materiali III Natsional'nogo kongressa (VIII zizdu) anesteziologiv Ukraini, Odesa, 16-19 travnia 2000: 207-210.
  2. Burchard K.W., Ciombor D.M., McLeod K.M., Slothman S.J., Gan I. End respiratory pressure with increased intraabdominal pressure. Surg. Gynecol. Obstet. 1985; 161: 313.
  3. Burch J.M., Moore E.E., Moore F.A., Franciose R. Abdominal compartment syndrome. Surg. Clin. North. Am. 1996; 76: 833-842.
  4. Ciresi D.L., Cali R.F., Senagore A.J. Abdominal closure using nonabsorbable mesh after massive resuscitation prevents abdominal compartment syndrome and gastrointestinal fi stula. Am. Surg. 1999; 65: 720-724.
  5. Cheatham M.L. Intra-abdominal hypertension and abdominal compartment syndrome. New.Horiz. 1995; 7:96-115.
  6. Cheatham M.L., Safcsak K., Block E.F., Nelson L.D. Preload assessment in patients with an open abdomen. J. Trauma 1999; 46: 16-22.
  7. Diebel L.N., Dulchavsky S.A., Brown W.J. Splanchnic ischemia and bacterial translocation in the abdominal compartment syndrome. J. Trauma 1997; 43: 852-855.
  8. Ertel W., Oberholzer A., Platz A., Stocker R., Trentz O. Incidence and clinical pattern of the abdominal compartment syndrome after "damage-control" laparotomy in 311 patients with severe abdominal and/or pelvic trauma. Crit Care Med. 2000; 28: 1747-1753.
  9. Ivatury R.R., Porter J.M., Simon R.J., Islam S., John R., Stahl W.M. Intra-abdominal hypertension after lifethreatening penetrating abdominal trauma: prophylaxis, incidence, and clinical relevance to gastric mucosal pH and abdominal compartment syndrome. J. Trauma 1998; 44: 1016-1021.
  10. Malbrain M.L.N.G. Relationship of body mass index (BMI), lactate and Intra-abdominal pressure (IAP) to subsequent mortality in ICU patients. Crit. Care. 1999; 3: 20.
  11. Malbrain M.L.N.G. Abdominal pressure in the critically ill. Curr. Opinion Crit Care 2000; 6:17-29.

Supplementary files

Supplementary Files
Action
1. JATS XML
Download

Copyright (c) 2010 ., ., ., ., ., .

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies