Differential Radiology Diagnostics of Metastasises of Renal Cell Carcinoma in the Pancreas

Abstract


Metastatic lesion of the pancreas is an extremely rare disease, which occupies 2-5% of all pancreatic tumors, and these figures rise to 11% according to autopsies of patients with malignant tumors. Metastatic lesion of the pancreas from primary renal cancer occurs most often (65-74%).
The purpose of the study Differential diagnosis of metastatic lesions of the pancreas
Materials and methods 6 patients with histologically confirmed diagnosis - metastatic renal cell cancer in the pancreas were treated in the period from 2009 to 2013 in " A.V. Vishnevsky Institute of Surgery. Nephrectomy in history was performed in 4 (66.7%) patients in the period from 4 to 16 years. Tumor of the left kidney in conjunction with metastatic pancreatic cancer was detected in 2 (33.3%) patients.
Results and their discussion Solitary metastases were detected in 4 (66.7%) patients. Tumors were located in the head of the pancreas in 3 patients, in the body - in 1. Multiple multifocal lesion of the pancreas was in 2 (33.3%) patients. Dimensions secondary structures ranged from 10 mm to 56 mm.
The most informative diagnostic method in detecting of focal lesions of the pancreas is computed tomography with bolus contrast enhancement . Significant difficulties for interpretation are small tumors that are similar in structure to hormonally active neuroendocrine neoplasm.
Conclusion Revealed solitary or multiple focal disease of the pancreas in patients after nephrectomy for renal cell carcinoma should be regarded primarily as secondary.

A.V. Vishnevsky Institute of Surgery, 27 Bol'shaia Serpukhovskaia Str., Moscow, 117997, Russian Federation

Author for correspondence.
Email: mail@vestnik-surgery.com
Ph.D., senior research of ultrasound department of A.V. Vishnevsky Institute of Surgery, Moscow

A.V. Vishnevsky Institute of Surgery, 27 Bol'shaia Serpukhovskaia Str., Moscow, 117997, Russian Federation Institute for Vocational Education I.M. Sechenov 1st MSMU, 8/2 Trubetskaia Str., Moscow, 119991, Russian Federation

Email: mail@vestnik-surgery.com
MD, senior research of ultrasound department of A.V. Vishnevsky Institute of Surgery; prof. of Radiology Department Institute for vocational education I.M. Sechenov 1st MSMU, Moscow

A.V. Vishnevsky Institute of Surgery, 27 Bol'shaia Serpukhovskaia Str., Moscow, 117997, Russian Federation Institute for Vocational Education I.M. Sechenov 1st MSMU, 8/2 Trubetskaia Str., Moscow, 119991, Russian Federation

Email: mail@vestnik-surgery.com
MD, Prof., Head of Radiology department of A.V. Vishnevsky Institute of Surgery; prof. of Radiology Department Institute for vocational education I.M. Sechenov 1st MSMU, Moscow

A.V. Vishnevsky Institute of Surgery, 27 Bol'shaia Serpukhovskaia Str., Moscow, 117997, Russian Federation

Email: mail@vestnik-surgery.com
MD, Prof., Head of Abdominal Surgery Department №1 A.V. Vishnevsky Institute of Surgery

A.V. Vishnevsky Institute of Surgery, 27 Bol'shaia Serpukhovskaia Str., Moscow, 117997, Russian Federation

Email: mail@vestnik-surgery.com
MD, senior research of Abdominal Surgery Department №1 A.V. Vishnevsky Institute of Surgery, Moscow

  • Crippa S., Angelini C., Mussi C. et al. Surgical treatment of metastatic tumors to the pancreas [Khirurgicheskoe lechenie metastaticheskikh opukholei podzheludochnoi zhelezy.] A single center experience and review of the literature. World J. Surg., 2006; 30: 1536-1542.
  • Ballarin R., Spaggiari M., Cautero N. et al. Pancreatic metastases from renal cell carcinoma: the state of the art [Pankreaticheskikh metastazy raka pochki: sostoianie iskusstva]. World J. Gastroenterol]., 2011; 17(43): 4747-4756.
  • Hung J.H., Wang S.E., Shyr Y.M. et al Resection for Secondary Malignancy of the Pancreas [Rezektsiia dlia vtorichnoi zlokachestvennosti PZh] .Pancreas, 2012; 41(1): 121-129.
  • David A.W., Samuel R., Eapen A. et al. Pancreatic metastasis from renal cell carcinoma 16 years after nephrectomy: a case report and review of the literature [Podzheludochnaia metastaz ot pochechno-kletochnogo raka cherez 16 let posle nefrektomii: doklad sluchai i obzor literatury]. Trop. Gastroenterol., 2006; 27: 175-176.
  • Machado N.O., Chopra P. Pancreatic metastasis from renal carcinoma managed by whipple resection. A case report and literature review of metastatic pattern, surgical manage-ment and outcome [Pancreatic metastasis from renal carcinoma managed by whipple resection. A case report and literature review of metastatic pattern, surgical manage-ment and outcome]. J. Pancreas, 2009; 10(4): 413-418.
  • You D.D., Choi D.W., Choi S.H. et al. Surgical resection of metastasis to the pancreas [Khirurgicheskaia rezektsiia metastazov v podzheludochnoi zheleze] J. Korean Surg. Soc., 2011 Apr; 80(4): 278-282.
  • Niees H., Conrad C., Kleespies A. et al. Surgery for metastasis to the pancreas: is it safe and Effective? [Khirurgicheskie vmeshatel'stva po povodu metastazov v podzheludochnoi zheleze: on bezopasen i effektiven?]. Journal of Surgical Oncology, 2013; 107: 859-864.
  • Tanis P.J., van der Gaag N.A., Busch O.R. et al. Systematic review of pancreatic surgery for metastatic renal cell carcinoma [Sistematicheskii obzor podzheludochnoi operatsii po povodu metastaticheskogo pochechno-kletochnogo raka]. Br. J. Surg., 2009; 96: 579-592.
  • Ballarin R., Spaggiari M., Cautero N. et al. Pancreatic metastases from cell carcinoma: the state of the art [Pankreaticheskikh metastazy iz-kletochnogo raka: sostoianie iskusstva]. Word J. Gastroenterology, 2011, November 21; 17(43): 4747-4756.
  • Shah S., Mortele K.J. Uncommon solid pancreatic neoplasms- ultrasound, computed tomography, and magnetic resonance imaging features [Neobychnoe tverdye pankreaticheskikh novoobrazovaniia-UZI, komp'iuternaia tomografiia, i osobennosti magnitno-rezonansnoi tomografii]. Semin Ultrasound CT MR, 2007 Oct;28(5):357-70.
  • Chou Y.H., Chiou H.J., Hong T.M. et al. olitary metastasis
  • from renal cell carcinoma presenting as diffuse pancreat
  • ic enlargement [Odinochnyye metastaz ot pochechno-kletochnogo raka predstavlyaya kak diffuznoye uvelicheniye podzheludochnoy zhelezy]. J. Clin. Ultrasound, 2002; 30(8): 499-502.
  • Giovannini M. . The place of endoscopic ultrasound in bilio-pancreatic pathology [Mesto provedeniia endoskopicheskogo ul'trazvukovogo issledovaniia v bilio-pankreaticheskogo patologii] .Gastroenterol. Clin. Boil., 2010; 34(8-9): 436-445.
  • Gilbert C.M., Monako S.E., Cooper S.T. Khalbuss W.E. . Endoscopic ultrasound-guided fine-needle aspiration if metastases to the pancreas:a study of 25 cases [Endosonograficheskie navedeniem tonkoigol'noi aspiratsii, esli metastazov v podzheludochnoi zheleze: issledovanie 25 sluchaev]. Cytojournal, 2011; 8: 7.
  • Rickes S., Monkemüller K., Malfertheiner P. Contrast-Enhanced Ultrasound in the Diagnosis of Pancreatic tumors [Kontrastnoe UZI v diagnostike opukholei podzheludochnoi zhelezy]. JOP, 2006; 7(6): 584-592.
  • Mecho S., Quiroga S., Cuellar H., Sebastia C. Pancreatic metastasis of renal cell carcinoma: multidetector CT findings [Podzheludochnaya metastazirovaniya pochechno-kletochnogo raka: Multidetector rezul'taty KT]. Abdom. imaging, 2009; 34(4): 385-389.
  • Palmowski M., Hacke N., Satzl S. et al. Metastasis to the pancreas: characterization by morphology and contrast enhancement features on CT and MRI/ Pancreatology [Metastazy v podzheludochnoi zheleze: kharakteristika morfologii i povyshenie kontrastnosti osobennostei na KT i MRT / pankreatologii]. Pancreatol., 2008; 8(2): 199-203.

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