Application of Biodegraded Polymers for Replacement of Bone Cavities at Chronic Osteomyelitis

Abstract


Relevance The problem of the treatment of chronic osteomyelitis is the focus of surgeons and traumatologists and does not lose its relevance over the years.  Interest is the biodegradable  polymers of microbial origil– polyhydroxyalkanoates (PHA), which have compatibility with the animal tissues, high mechanical strength, which makes them promising materials for use in medicine.

The purpose of the study An experimental basis for the use of biopolymers - PGA - in the treatment of chronic osteomyelitis.

Materials and methods The study included 60 males- rabbits of Chinchilla breed.  A bone defect in the first study group completed filling powder from the PGA, the second - the implant, based on PGA and antibacterial drug of carbapenem antibiotic group (thienam) combined 10:1, in the comparison group – autogenous bone (bone autotrasplantant). Removal of animals from the experimental and collection of  the material was carried out on 30 th, 90 th day of  the observation. We evaluated clinical parameters, Х-ray pictures, microbiological and morphological results.

Results and their discussion When plastic osteomyelitic cavity filling material PGA restore the functional properties of the operated lower limbs was happening 1.2 times faster than in the comparison group. Radiographically proven that the use of the material structure of the PGA restoration of bone tissue and the defect occurred in the second study group. Morphogenesis of reparative processes after plastic PGA characterized restoration of anatomic and functional integrity of the bone to the 90 th day.

Conclusion The results allow us to recommend the PGA as osteoplastic material for reconstruction of bone defects and  require further study.


Krasnoyarsk State Medical university by prof. V.F. Voyno-Yasenetsky, Krasnoyarsk, Russian Federation

Author for correspondence.
Email: author@vestnik-surgery.com
prof., head of general krasnoyarsk State Medical University by prof. V.F.Voyno-Yasenetsky

Siberian Federal University, Krasnoyarsk, Russian Federation

Email: author@vestnik-surgery.com
Ph.D., Head. Department of Medical Biology, Siberian Federal university, Institute of Basic Biology and Biotechnology

Krasnoyarsk State Medical university by prof. V.F. Voyno-Yasenetsky, Krasnoyarsk, Russian Federation

Email: author@vestnik-surgery.com
Ph.D., PhD, Department of general Surgery Krasnoyarsk State Medical University by prof. V.F.Voyno-Yasenetsky

Krasnoyarsk State Medical university by prof. V.F. Voyno-Yasenetsky, Krasnoyarsk, Russian Federation

Email: author@vestnik-surgery.com
a graduate student, Department of general Surgery krasnoyarsk State Medical university by prof. V.F.Voyno-Yasenetsky

Krasnoyarsk State Medical university by prof. V.F. Voyno-Yasenetsky, Krasnoyarsk, Russian Federation

Email: author@vestnik-surgery.com
Ph.D., Krasnoyarsk State Medical University by prof. V.F.Voyno-Yasenetsky

Krasnoyarsk State Medical university by prof. V.F. Voyno-Yasenetsky, Krasnoyarsk, Russian Federation

Email: author@vestnik-surgery.com
Ph.D., head of Microbiology. assoc. BM zelmanowitz , krasnoyarsk State Medical University by prof. V.F.Voyno-Yasenetsky

Siberian Federal University, Krasnoyarsk, Russian Federation

Email: author@vestnik-surgery.com
graduate student, Siberian Federal university, Institute of Basic Biology and Biotechnology

Krasnoyarsk State Medical university by prof. V.F. Voyno-Yasenetsky, Krasnoyarsk, Russian Federation

Email: author@vestnik-surgery.com
MD, PhD, Department of general Surgery, Krasnoyarsk State Medical University by prof. V.F.Voyno-Yasenetsky

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