The Modern View on the Effectiveness of Cradiotherapy of Prostate Cancer

Abstract


For many years the main method of treatment of patients with prostate cancer remains surgical treatment, which consists in performing a difficult and traumatic operations, leading to reduced quality of life. Currently, as an equal alternative to radical prostatectomy is radiotherapy, presented with a standard 3D conformal beam radiation, stereotactic radiotherapy and brachytherapy using sources with a low or high dose. Brachytherapy using sources of high power is a safe and effective treatment for localized prostate cancer, providing a summing fatal dose to the tumor with the short period of hospitalization, minimal complications, which may be used in combination with external beam radiotherapy and standalone version. A brief review of the literature on the use of combined radiation therapy in the treatment of prostate cancer. Describes the comparative characteristics of results of treatment of this pathology, complications, early and late toxic reactions when used brachytherapy isotopes of different dose in combination with external beam radiation therapy. The vector of further research in this direction is justified.


Ivan Petrovich Moshurov

The VGMA them. N. N. Burdenko, Department of Oncology IDPO, BUZ VO " Voronezh regional clinical Oncology dispensary".

Email: moshurov@vokod.vrn.ru
ORCID iD: 0000-0003-1333-5638
SPIN-code: 6907-2629

Russian Federation, 10 Studencheskaya Str., Voronezh, 394036, Russian Federation 4 Vaytsehovskaya Str., Voronezh, 394036, Russian Federation

head of Department of Oncology IDPO VSMU them. N. N. Burdenko, head doctor of BUZ VO BOKOD

Dmitry Yuryevich Kamenev

The VGMA them. N. N. Burdenko, Department of Oncology IDPO, BUZ VO " Voronezh regional clinical Oncology dispensary".

Author for correspondence.
Email: kamenev_dmitrii@mail.ru
ORCID iD: 0000-0001-9774-9496
SPIN-code: 2478-7289

Russian Federation, 10 Studencheskaya Str., Voronezh, 394036, Russian Federation 4 Vaytsehovskaya Str., Voronezh, 394036, Russian Federation

assistant Professor of Oncology IDPO VSMU them. N. N. Burdenko, oncologist, radiologist BUZ VO BOKOD.

Bronislava Borisovna Kravets

The VGMA them. N. N. Burdenko, Department of Oncology IDPO, BUZ VO " Voronezh regional clinical Oncology dispensary".

Email: kravets@vokod.ru

Russian Federation, 10 Studencheskaya Str., Voronezh, 394036, Russian Federation 4 Vaytsehovskaya Str., Voronezh, 394036, Russian Federation

MD, Professor, Department of Oncology IDPO, Deputy chief physician BUZ IN BOKOD.

Natalia Viktorovna Korotkikh

The VGMA them. N. N. Burdenko, Department of Oncology IDPO, BUZ VO " Voronezh regional clinical Oncology dispensary".

Email: kornat78@mail.ru
ORCID iD: 0000-0002-0308-513X
SPIN-code: 2212-6667

Russian Federation, 10 Studencheskaya Str., Voronezh, 394036, Russian Federation 4 Vaytsehovskaya Str., Voronezh, 394036, Russian Federation

PhD, assistant Professor of Oncology IDPO, head of the radiology Department No. 5 BUZ IN BOKOD

  1. Alekseev B. Ya. Clinical guidelines for the diagnosis and treatment of patients with prostate cancer. Moscow, 2013;42.
  2. Golub S. V., al'bitskiy, I. A., Combined radiation therapy of prostate cancer // Health and education in the 21st century. 2011;2:13:238.
  3. Ivanov S. A. Brachytherapy as a method of radical treatment of prostate cancer. // Avtoref. ..Doc. med. of Sciences, Moscow. 2011;48.
  4. Kaprin A. D., Chmielewski, E. V., Semin V. A. Combined radiation therapy as alternative to surgical treatment for locally advanced prostate cancer // journal of Russian scientific center of roentgenology and radiology, Ministry of health of Russia. 2008;8:1.
  5. Kostylev V. A. analysis of the status of radiation Oncology in the world and in Russia // Medical physics. 2009;3:5-20.
  6. Ovchinnikov V. A., Dovnar O. S. Effectiveness of high-dose rate brachytherapy in the radical treatment of prostate cancer // Actual problems of medicine. 2013;97-110.
  7. Pavlov A. Yu. Vysokomolochnye brachytherapy source of ir-192 in the treatment of prostate cancer // III Scientific-practical conference “Fundamental and practical urology.” Moscow: 2014; 147-152.
  8. Semin A.V. Combined radiation therapy in the treatment of localized and locally advanced prostate cancer. // Author's abstract... Cand.med. of Sciences, Moscow. 2010;36.
  9. Sycheva I. V., Passes V. V., A. K. Kurpesheva Conservative methods of treatment of local radiation injuries resulting combined radiation therapy and brachytherapy of prostate cancer // Siberian journal of Oncology. 2012; 5: 53: 57-60.
  10. Bortolus R. [Radiation therapy in locally advanced and/or relapsed urological tumors]. // Urologia. 2013; 80:3: 212–24.
  11. Demanes D.J. и др. High-dose-rate intensity-modulated brachytherapy with external beam radiotherapy for prostate cancer: California endocurietherapy’s 10-year results. // Int. J. Radiat. Oncol. Biol. Phys. 2005;61: 5: 1306–16.
  12. Fröhlich G. и др. Dosimetric evaluation of high-dose-rate interstitial brachytherapy boost treatments for localized prostate cancer. // Strahlenther. Onkol. 2010; 186: 7: 388–95.
  13. Heidenreich A. и др. Рак предстательной железы / под ред. Б.Я. Алексеев, В.Б. Матвеев. : Европейская ассоциация урологов, 2011:70
  14. Hsu I.-C. и др. Phase II trial of combined high-dose-rate brachytherapy and external beam radiotherapy for adenocarcinoma of the prostate: preliminary results of RTOG 0321. // Int. J. Radiat. Oncol. Biol. Phys. 2010;78: 3: 751–8.
  15. Hsu I.-C.J. и др. AMERICAN BRACHYTHERAPY SOCIETY PROSTATE HIGH-DOSE RATE TASK GROUP Guidelines. , 2008.
  16. Hsu I.-C.J. и др. ACR Appropriateness Criteria high-dose-rate brachytherapy for prostate cancer. // Brachytherapy. 2014; 13: 1: 27–31.
  17. Izard M.A. и др. Long-term outcome for prostate cancer using pseudo pulse-dosed rate brachytherapy, external beam radiotherapy, and hormones. // Brachytherapy. 2013; 12: 6: 608–14.
  18. Lo A., Nam R.K., Loblaw A. HDR monotherapy for man with radiotherapy contraindications and prostate cancer. // Can. J. Urol. 2011; 18: 4: 5839–43.
  19. Martinez A. и др. Pelvic lymphadenectomy combined with transperineal interstitial implantation of iridium-192 and external beam radiotherapy for locally advanced prostatic carcinoma: technical description. // Int. J. Radiat. Oncol. Biol. Phys. 1985; 11: 4: 841–7.
  20. Martinez A.A. и др. Interim report of image-guided conformal high-dose-rate brachytherapy for patients with unfavorable prostate cancer: the William Beaumont phase II dose-escalating trial. // Int. J. Radiat. Oncol. Biol. Phys. 2000; 47: 2: 343–52.
  21. Matsunobu A. и др. [High-dose-rate brachytherapy with external beam radiotherapy for localized or locally advanced prostate cancer]. // Fukuoka Igaku Zasshi. 2010; 101: 4: 75–83.
  22. Strom T.J. и др. High-dose-rate brachytherapy with or without intensity modulated radiation therapy as salvage treatment for an isolated, gross local recurrence of prostate cancer post-prostatectomy. // Brachytherapy. 2014b; 13: 2: 123–7.
  23. Wilder R.B. и др. Preliminary results in prostate cancer patients treated with high-dose-rate brachytherapy and intensity modulated radiation therapy (IMRT) vs. IMRT alone. // Brachytherapy. 2010;. 9: 4:. 341–8.
  24. Zaider M. и др. Methodology for biologically-based treatment planning for combined low-dose-rate (permanent implant) and high-dose-rate (fractionated) treatment of prostate cancer. // Int. J. Radiat. Oncol. Biol. Phys. 2005; 61: 3: 702–13.

Views

Abstract - 184

PDF (Russian) - 122

PlumX

Dimensions


Copyright (c) 2017 Moshurov I.P., Kamenev D.Y., Kravets B.B., Korotkikh N.V.

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies