Bone Subdestructive Kryoapplicaton in the Experiment

Abstract


Relevance. Trend of modern surgery in the implementation of new methods of treatment is to develop all phases of the proposed method of treatment in an experimental model. In this paper, comparative studies have been performed in laboratory animals, aimed at studying the bone tissue reaction at subdestruktion cryotherapy.

Purpose. Identify the optimal exposure of the refrigerant to achieve kryoregenerative action ultralow temperatures.

Materials and methods. An experimental study was conducted on rabbits "Chinchilla" by cryotherapy in the cavity osteoperforation with different exposure refrigerant (liquid nitrogen). After 10 days after the removal of the animal from an experiment conducted morphological study.

Results. It was found that the exposure of 3 seconds is observed active regeneration, while kryoosteonekrosis observed during long-term exposure. The experimental results allow differentiated recommend them for use in clinical practice.

Conclusion. Light microscopy kryoregeneration with a three-second exposure shows the refrigerant is very active calcification regenerate. Primary callus composed of fibrous tissue and retikulofibrosis. Reclaimed presented osteoblasts chain. The proposed regime is advisable to apply cryotherapy with degenerative diseases of the bone in order to increase osteoreparative properties of bone.


Ivan Ivanovich Kuzhelivskiy

Siberian State Medical University

Author for correspondence.
Email: kuzhel@rambler.ru

Russian Federation, 634050, Tomsk, Moskovskiy trskt str, 2

MD, PhD, associate professor of pediatric surgical diseases department

Grigoriy Vladimivorich Slizovskiy

Siberian State Medical University

Email: sgv5858@mail.ru

Russian Federation, 634050, Tomsk, Moskovskiy trskt str, 2

MD, PhD, DSc, Associate Professor, Head of department of pedistric surgery

Leonid Aleksandrovich Sitko

Omsk State Medical University

Email: kuzhel@rambler.ru

Russian Federation, 644099, Omsk, Lenina str, 12

Honored Scientist of Russia, Honored doctor, MD, PhD, DSc, professor of pediatric surgery

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Copyright (c) 2017 Kuzhelivskiy I.I., Slizovskiy G.V., Sitko L.A.

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