Role in Hypoxic Cascade Trigger Mechanisms of Acute Pancreatitis

Relevance One understudied mechanisms of pathogenesis of acute pancreatitis (AP ) , the question remains significance hypoxic cascade trigger mechanisms of disease development. The purpose of the study Set the importance of hypoxic cascade trigger mechanisms of acute pancreatitis. Materials and methods Work carried out on 20 adult mongrel dogs of both sexes mature weight from 8.6 to 12.3 kg. Animals modeled edematous form OP. In terms of control studies (1 , 3 and 5 th day ) produced relaparotomii in pancreatic tissue examined intraoperatively microcirculation and tissue respiration indices . Body tissue biopsy was performed to investigate the free-radical processes , determine the qualitative and quantitative composition of lipids . For normal performance was studied their levels in 10 healthy animals. Results and their discussion Studies have shown that the development of the edematous form of acute pancreatitis maximum reduction in body tissue microcirculation with increased index of grafting ( 230% ) developed on the third day . Under the conditions of disturbed microcirculation , there is a deficiency of oxygen , which causes the phase separation processes of electron transport in mitochondria and , as a consequence, the appearance of free oxygen radicals which can initiate lipid peroxidation and activate phospholipase systems with membranodestruktivnym action. Conclusion The resulting factual material in a generalized form gives reason to postulate that one of the most important trigger of the pathogenetic mechanisms of acute pancreatitis is the circulatory hypoxia , which underlies the formation of hypoxic cascade triggering "run" membranodestruktivnyh processes

Острый панкреатит, патогенез, микроциркуляция, тканевое дыхание, оксидативный и фосфолипазный стресс, мембранодеструкция, гипоксический каскад