Analysis of the Ratio of Collagen Types I and III in Skin and Aponeurosis in Patients with Ventral Hernias

Abstract


Relevance Disorder of the connective tissue remodeling in patients after surgical treatment of ventral hernias is the great problem of modern herniology. Pathology of the connective tissue is considered as the main cause of this disorder, and is closely connected with the disturbance of collagen metabolism in the zone of post operation scar. The purpose of the study Study the relationship between collagen type I and III of the connective tissue in skin and aponeurosis in patients with hernia disease and with another surgical pathology. Materials and methods Comparative investigation of the skin and aponeurosis connective tissue structure was performed in 95 patients, suffering from ventral hernias, with the help of polarization microscopy. All patients were divided into two groups: 46 patients with ventral hernias and 49 patients with another surgical pathology. Results and their discussion In patients with hernias had significantly lower ratio of TC (p≤0,001) as in the preparation of the skin, and aponeurosis compared with patients without hernia. It was revealed strong direct correlation dependence between the connective tissue structure of skin and of aponeurosis, which makes the prognosis of ventral hernia development possible with the help of investigation of the skin structure. Conclusion In patients with WG had significantly (P ≤ 0,001) lower ratio of TC in the skin and aponeurosis. Collagen composition of the connective tissue of the skin and aponeurosis are in a strong direct correlation (r=0,72), which makes it possible to judge the changes in the structure of the aponeurosis in terms of the ratio of collagen in the skin. The use of polarization microscopy to determine the proportion of collagen types I and III in the preparations of the skin and aponeurosis is highly informative in the verification of hernia disease

Kursk State Medical University, Kursk, Russian Federation

Author for correspondence.
Email: author@vestnik-surgery.com
PhD, associate professor, department of surgical diseases № 1 of the Kursk State Medical University

Kursk State Medical University, Kursk, Russian Federation

Email: author@vestnik-surgery.com
MD, professor, rector of the Kursk State Medical University

Kursk State Medical University, Kursk, Russian Federation

Email: author@vestnik-surgery.com
MD, professor, head of surgical diseases № 1 of the Kursk State Medical University

Kursk State Medical University, Kursk, Russian Federation

Email: author@vestnik-surgery.com
PhD, associate professor, department of Pathological Anatomy of the Kursk State Medical University

Kursk State Medical University, Kursk, Russian Federation

Email: author@vestnik-surgery.com
clinical intern, department of surgical diseases № 1 of the Kursk State Medical University

  • Borisov, A.E. Malkova S.K., Toidze V.V. Primenenie polipropilenovoj setkoj dlya krupnyh i gigantskih gryzh bryushnoj stenki [Application
  • of polypropylene mesh for large and giant hernias of the
  • abdominal wall]. Vestnik khirurgii, 2002; 6: 76-78. - (In
  • Russian)
  • Veligotskii N.N. Komarchuk V.V, Komarchuk E.V.,
  • Kasumba K. Hirurgicheskoe lechenie gryzh na fone displazii soedinitel'noj tkani [ Surgical treatment of hernias against the
  • background of the connective tissue dysplasia]. Ukrainskii
  • Khirurgicheskii Zhurnal, 2011; 3(12): 236-239 - (In Russian)
  • Vol'nyi S.V. Kliniko-morfologicheskie osobennosti
  • pakhovykh gryzh v svete narushenii kollagenovogo obmena.
  • Avtoref. dis. kand. med. nauk [Clinical and morphological
  • peculiarities of the inguinal hernias in the light of the
  • violations of collagen exchange. Synopsis cand. med. sci.
  • diss.]. Moscow, 2010; 20 p. - (In Russian)
  • Gorelov A.S. Obosnovanie i otsenka effektivnosti
  • primeneniia setchatykh implantatov iz polivinilidenftorida
  • pri gernioplastike posleoperatsionnykh ventral'nykh gryzh
  • (eksperimental'no-klinicheskoe issledovanie). Avtoref.
  • diss. kand. med. nauk [Study and assessment of efficiency
  • of application of mesh implants of PVDF with hernioplastic
  • postoperative ventral hernias (experimental and clinical
  • research). Synopsis cand. med. sci. diss.]. Saint-Petersburg,
  • ; 23 p. - (In Russian)
  • Dubova E.A. Morfologicheskaia kharakteristika tkanevoi
  • reaktsii pri implantatsii setchatykh endoprotezov. Avtoref.
  • diss. kand. med. nauk [Morphological characteristics of
  • tissue reaction implantation mesh implants. Synopsis cand.
  • med. sci. diss.]. Moscow, 2008; 23 p. - (In Russian)
  • Zotov V.A., Shtofin S.G., Shestakov V.V., Ovchinnikov V.V.
  • Hirurgiya gryzh bryushnoj stenki s plastikom "bez natyazheniya" [Surgery hernias of the abdominal wall with plastic "without
  • tension"]. Vestnik gerniologii, 2006; 2: 81-86. - (In Russian)
  • Kakturskii L.V. Poliarizatsionnaia mikroskopiia.
  • Mikroskopicheskaia tekhnika [Polarizing microscopy.
  • Microscopic techniques]. Moscow, Medicina Publ., 1996;
  • p. - (In Russian)
  • Pushkin S.Iu. Belokonev V.I. Rezul'taty lecheniya bol'nyh sredinnoj bryushnoj gryzhi s primeneniem sinteticheskih
  • implantaty [Results of treatment of
  • patients median ventral hernia with application of synthetic
  • implants]. Khirurgiia. Zhurnal im. N.I. Pirogova, 2010; 6:
  • -45. - (In Russian)
  • Timoshin A.D. Iurasov A.V., Shestakov A.L. Hirurgicheskoe lechenie posleoperacionnyh gryzh bryushnoj stenki [Surgical
  • treatment of postoperative hernia of the abdominal wall].
  • Gerniologiia, 2004; 1: 5–4. - (In Russian)
  • Shpekht D.Iu. Kliniko-morfologicheskaia kharakteristika
  • posleoperatsionnykh ventral'nykh gryzh perednei briushnoi
  • stenki v vybore optimal'nogo sposoba plastiki. Diss. kand.
  • med. nauk [Clinical and morphological characteristics of
  • postoperative ventral hernias of the anterior abdominal wall
  • in the choice of optimal method of plasty. Synopsis cand.
  • med. sci. diss.]. Astrakhan, 2004. 85 p. - (In Russian)
  • Agrawal A., Avill R. Setka migracii posle remonta pahovoj gryzhe: otchet o sluchaya i obzor literatury [Mesh migration following repair of
  • inguinal hernia: a case report and review of literature].
  • Hernia, 2005; 29: 1-4.
  • Bernd Klosterhalfen; Karsten Junge; Uwe Klinge. Malyj ves i bol'shoj poristoj koncepciya setki dlya gernioplastiki [The
  • lightweight and large porous mesh concept for hernia
  • repair]. Expert review of medical devices, 2005; 2(1): 103-17.
  • Godek M.L., Duchsherer N.L., Mc Elwee Q., Grainger
  • D.W. Morfologiya i rost myshinyh kletochnyh linij na rezhime biomaterialov [Morphology and growth of murine cell lines on model
  • Biomaterials]. Biomed. Sci. Instrum, 2004; 40: 7-12.

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