Study of the Effects of Different Methods of the Treatment of Purulent Wounds on the Formation of a Scar

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The purpose of the study The purpose of the study is to substantiate morphologically the effectiveness of various methods of the treatment of purulent wounds on the basis of the analysis of structural and functional state of the regenerate. Materials and methods The experiment was conducted on 70 inbred male albino rats with the weight of 200-220 g. Modeling of purulent wounds was performed using the culture of St. aureus. All the animals were divided into 2 control and 3 experimental groups depending on the method of regional treatment. Alternating electromagnetic field, light therapy and introduction of platelet-rich auto plasma were used for the treatment. These methods were utilized after the treatment of wounds by jet sanation of 0.9% NaCl solution. The animals were withdrawn under anesthesia from the experiment on the 21st day. Each group consisted of 2 subgroups: for the intake of the histological material and for the evaluation of the mechanical properties of scar tissue. Gistological as well as morphometric techniques were used, and the wound-breaking strength was estimated. Results and their discussion The combined use of jet sanation and platelet-rich auto plasma creates more positive preconditions for the formation of qualitative scars. The greatest strength of the scar is observed in those groups, where jet sanation and platelet-rich plasma are used. The increase in the diameter of collagen fibers does not reflect the presence of linear dependence on the strength characteristics of the tissues. Conclusion The combined use of jet sanation and platelet-rich auto plasma provides regeneration with the formation of tissues that have sufficient physical and biological strength.

About the authors

N.N. Burdenko Voronezh State Medical Academy, 10 Studencheskaia Str., Voronezh, 394036, Russian Federation

Author for correspondence.
Candidate of Medical Science, Associate Professor of the Department of Normal Human Anatomy of Voronezh State Medical Academy named after N.N. Burdenko

I.M. Sechenov First Moscow State Medical University, 8 Trubetskaia Str., 119991, Moscow, Russian Federation

Doctor of Medical Science, Professor of the Department of Normal Anatomy of the First Moscow State Medical University named after I.M. Sechenov

N.N. Burdenko Voronezh State Medical Academy, 10 Studencheskaia Str., Voronezh, 394036, Russian Federation

 Doctor of Medical Science, Professor, Corresponding Member of the RANH, Head of the Department of General Surgery, Director of the Institute of Surgical Infection of Voronezh State Medical Academy named after N.N. Burdenko, Honored Inventor of the Russian Federation, Chairman of the Voronezh Branch of the Russian Society of Surgeons.


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