Endothelial Disfunction in the Long Term Cold Injury

The purpose of the study To assess the state of endothelial dysfunction in the long term frostbite injures Materials and methods The content of soluble vascular adhesion molecules sICAM- 1 , sVCAM- 1 , sE-selectin, sP-selectin in 31 patients in the long term deep frostbite limbs in comparison with the clinical characteristic pathology. Developing complications systematized and structured in accordance with modern views on the molecular and cellular mechanisms of inflammation. Results and their discussion Long term period of frostbite injures is characterized by a high incidence of complications. Only 10 % of victims within 5 years can be considered healthy. Among the most important are the complications of circulatory disorders and infections of the bone and mild tissues. The development of such complications in 33 % of cases require high performing amputations leading to disability. Level of endothelial dysfunction significantly reflects the severity of long-term complications of frostbite , especially occlusive vascular lesions . Values of sICAM- 1, sVCAM- 1, sP-selectin in the group affected with severe limb ischemia is 1,5-2 times higher than the values of healthy persons in the same age group and can be used as a criterion for the duration of anticoagulant , antiplatelet and anti-inflammatory therapy on an outpatient stage of treatment . Conclusion Correction of endothelial dysfunction should be included in a comprehensive treatment and rehabilitation of patients with frostbite injures

Отморожение, эндотелиальная дисфункция, молекулы адгезии