Pilot clinical trial of tissue engineered constructs consisting of autologous stromal cells from adipose tissue in patients with bone tissue deficiency in the field of the alveolar process of maxilla and mandible


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Abstract

Despite the progress in conventional methods of maxillofacial surgery, which are based on the substitution of bone defects, alternative methods are being intensively developed. Recent studies focused on the use of a variety of matrices either inorganic or organic (autologous bone) have shown the limitations of these materials: inorganic matrices do not possess sufficient osteoinductive capacity and autologous bone cannot be obtained in large amounts. The presented results of the pilot clinical trial point to the fact that the introduction of tissue engineered constructs consisting of stromal cells from adipose tissue and osteoinductive materials have a beneficial effect on wound healing and formation of new bone tissue.

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Московский государственный медико-стоматологический университет

Author for correspondence.
Email: author@vestnik-surgery.com
Дробышев Алексей Юрьевич – д.м.н., проф., зав. кафедрой госпитальной хирургической стомато- логии и челюстно-лицевой хирургии Московского государственного медико-стоматологического уни- верситета; e-mail: dr.drobyshev@gmail.com

Московский государственный университет им. М.В.Ломоносова

Email: author@vestnik-surgery.com
Рубина Ксения Андреевна – к.б.н., доцент, стар- ший научный сотрудник научно-исследовательской лаборатории постгеномных технологий в медицине Московского государственного университета им. М.В.Ломоносова; e-mail: rkseniya@mail.ru

Московский государственный университет им. М.В.Ломоносова

Email: author@vestnik-surgery.com
Сысоева Вероника Юрьевна – старший преподава- тель кафедры медицинской биохимии и молекуляр- ной медицины Московского государственного уни- верситета им. М.В.Ломоносова; e-mail: veroniks@ mail.ru

Московский государственный университет им. М.В.Ломоносова

Email: author@vestnik-surgery.com
Калинина Наталья Игоревна – доцент, старший научный сотрудник научно-исследовательской ла- боратории генных и клеточных технологий Мо- сковского государственного университета им. М.В.Ломоносова; e-mail: n_i_kalinina@mail.ru

Московский государственный университет им. М.В.Ломоносова

Email: author@vestnik-surgery.com
Григорьева Ольга Александровна – аспирант кафе- дры медицинской биохимии и молекулярной меди- цины Московского государственного университета им. М.В.Ломоносова; e-mail: o_grigorieva@list.ru

Федеральный научно-клинический центр детской гематологии, онкологии и иммунологии

Email: author@vestnik-surgery.com
Мелерзанов Александр Викторович – к.м.н., стар- ший научный сотрудник лаборатории информатики и биофизики Федерального научно-клинического центра детской гематологии, онкологии и иммуно- логии; e-mail: m83071@gmail.com

Федеральный научно-клинический центр детской гематологии, онкологии и иммунологии

Email: author@vestnik-surgery.com
Румянцев Cергей Александрович – д.м.н., проф., врач-педиатр высшей категории, руководитель от- дела молекулярной и экспериментальной гемато- логии Федерального научно-клинического центра детской гематологии, онкологии и иммунологии; e-mail: s_roumiantsev@mail.ru

Московский государственный медико-стоматологический университет

Email: author@vestnik-surgery.com
Чаусская Ирина Юрьевна – аспирант кафедры го- спитальной хирургической стоматологии и челюст- но-лицевой хирургии Московского государствен- ного медико-стоматологического университета; e-mail: dr.chausskaya@mail.com

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