Membranostabilization Component in Preventions of the Hepatic Disfunctions of Acute Pancreatitis


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Abstract

Relavance Despite on considerable achievements of the contemporary medical sciences one is the actual problems in abdominal surgical of the present time to be problem on acute pancreatitis.
The purpose of the study Is established in experimental of the pathogenetics mechanisms a affects of hepar for acute pancreatitis; established on effectiveness of the antioxidant etoxidoli in their preventions.
Material and methods The study is based on materials of experimental studies. The acute pancreatitis is a simulated by the method of V.M. Buyanov et al. (1989). The adult mongrel dogs performed a median laparotomy, punctured gallbladder, bile were taken with followed by ligation of the puncture site. Bile then injected into the parenchyma of the vertical parts of the pancreas of 0,6 ml in 5 points. It the control periods of the investigation (the first, third and fifth day) animals collected the blood, biopsy of the hepar.
Results and their discussion The exposed that on the background of acute pancreatitis a occurring affects on contiguous organs and systems of organism, in our incident – hepar. One of causes a advances and generalizations on a inflammatory processes in abdominal cavity and formation of hepatic insufficiency the project at disbalances on lipid metabolisms in cellular structures of present organs. 
Development of membranodestructions processes in hepatic tissue on dependent at the uncontrolled flow a clearradical reactions, leading to initiation of lipid peroxidations at the cells membranes and activation on lipolytic enzymes where the greatest significance have a phospholipase A2. At the present changes proceed on background of deep depressions for antioxidants enzyme systems.
Conclusion Established of experimental that antioxidant of etoksidol causing a fast (already the first day on applications) and a significant inhibition on the processes of lipid proxidations of the hepar tissue structures. The important pathogenetic effects of preparations to be reduce the activity of phospholipase A2 of study tissue and increase its own antioxidant protections that and bring pronounced of a membranoprotectors action of etoxidoli

About the authors

Mordovian N.P. Ogareva State University, 68 Bolshevistskaia Str., Saransk, 430005, Russian Federation

Author for correspondence.
Email: vap.61@yandex.ru
DM, professor, the head of faculty surgery department Mordovian N.P. OgarevaState University

Mordovian N.P. Ogareva State University, 68 Bolshevistskaia Str., Saransk, 430005, Russian Federation

Email: saxin.alexei1985@yandex.ru
 CM, candidate for a doctor's degree of faculty surgery department Mordovian N.P. Ogareva State University

Mordovian N.P. Ogareva State University, 68 Bolshevistskaia Str., Saransk, 430005, Russian Federation

Email: asg.72@list.ru
 CM, reader, the head of surgical diseases department medical faculty of the atomic energetic institute of Obninsk

Mordovian N.P. Ogareva State University, 68 Bolshevistskaia Str., Saransk, 430005, Russian Federation

Email: mvvolk.1987@yandex.ru
postgraduate student of faculty surgery department Mordovian N.P. Ogareva State University

Mordovian N.P. Ogareva State University, 68 Bolshevistskaia Str., Saransk, 430005, Russian Federation

Email: asp87@rambler.ru
postgraduate student of faculty surgery department Mordovian N.P. Ogareva State University

Mordovian N.P. Ogareva State University, 68 Bolshevistskaia Str., Saransk, 430005, Russian Federation

Email: docm.88@yandex.ru
postgraduate student of faculty surgery department Mordovian N.P. Ogareva State University

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